30364-57-9

Usage

Chemical structure

2,5-Pyrrolidinedione, 1-[(4-methoxybenzoyl)oxy]-

Classification

Thienodiazepine

Uses

Sedative, anxiolytic, and hypnotic for anxiety, insomnia, and panic attacks

Mechanism of action

Enhances the effects of GABA neurotransmitter

Popularity

Common in medical field and as a research chemical

Risks

Potential for abuse and addiction

Recommendation

Close monitoring and regulation to prevent harm

Upstream product

• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 
• 100-09-4 4-methoxybenzoic acid 
• 123-11-5 4-methoxy-benzaldehyde 
• 105-13-5 4-Methoxybenzyl alcohol 
• 201230-82-2 carbon monoxide 
• 696-62-8 para-iodoanisole 
• 66107-29-7 4-methoxyphenyl triflate 
• 17592-54-0 2,5-dioxopyrrolidin-1-yl formate 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 128625-52-5 benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate 
• 5672-89-9 N-trifluoroacetoxy succinimide 

Downstream Products

• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 
• 57463-79-3 [2-(4-Methoxy-benzoylamino)-acetylamino]-acetic acid 
• 142947-60-2 N,N'-bis<6-(4-methoxybenzamido)hexanoyl>cystamine 
• 2280-99-1 N-butyl-p-methoxybenzamide 
• 13214-64-7 N-(4-methoxybenzoyl)glycine 
• 3400-22-4 4-methoxy-N-methylbenzamide 
• 51220-57-6 ethyl 2-(4-methoxybenzamido)acetate 
• 1485-70-7 N-benzylbenzamide 
• 105746-31-4 (R)-2-(4-Methoxy-benzoylamino)-3-phenyl-propionic acid 
• 1251532-95-2 N-((1R,2R)-2-(3-(3,5-bis(trifluoromethyl)phenyl)thioureido)cyclohexyl)-4-methoxybenzamide 
• 6346-07-2 4-methoxy-N-(2-phenylethyl)benzamide 
• 7465-88-5 4-methoxy-N-phenylbenzamide 
• 57700-94-4 N-(p-methoxybenzoyl)piperidine 
• 7504-58-7 N-(4-methoxybenzoyl)morpholine 

Relevant academic research and scientific papers

Homogeneous hydrogenation of substituted (Z) - ene-1,2-dicarbamates with rh(i) phosphine complexes

Homogeneous hydrogenation of substituted (Z)-ene-1,2-di-(-)-(1R, 3R, 4S)-methylcarbamate catalysed by rhodium complexes containing (+)-(2S,3S) or (-)-(2R,3R)-isopropylidene-2,3-dihydroxy-1,4-bis(diphenylphosphino)butane (DIOP) gives rise to the saturated

N -Heterocyclic carbene (NHC) catalyzed amidation of aldehydes with amines via the tandem N -hydroxysuccinimide ester formation

A facile method for the amidation of aldehydes by a cascade approach was developed. This methodology, reported for the first time, uses a N-heterocyclic carbene (NHC) as the catalyst, and N-hydroxysuccinimide (NHS) mediated synthesis of amides utilising TBHP as the oxidant. Various substituted aldehydes reacted smoothly with NHS giving the corresponding active esters in moderate to good yields, which facilely converted into amides in one pot. In addition, the drug moclobemide was synthesized to represent the practical utility of the developed methodology. This journal is

Formation of 1-hydroxymethylene-1,1-bisphosphinates through the addition of a silylated phosphonite on various trivalent derivatives

An easily handled one-pot synthetic procedure was previously developed for the synthesis of bisphosphinates starting from acyl chlorides. Herein, other trivalent derivatives as acid anhydrides and activated esters were tested to form various bisphosphinates. This modulation of the reactivity can be controlled according to the nature of the acid derivative for the use of sensitive and functionalized substrates.

A photoinduced cross-dehydrogenative-coupling (CDC) reaction between aldehydes and N-hydroxyimides by a TiO2-Co ascorbic acid nanohybrid under visible light irradiation

In this study, we performed a visible light-mediated aerobic photo-cross dehydrogenative coupling (CDC) reaction between aldehydes and N-hydroxyimides using TiO2-AA-Co as a photocatalyst for the synthesis of active esters. The synergistic and selective effects of the cobalt ascorbic acid complex (Co-AA) and TiO2 nanoparticles on the visible-light photocatalytic activity were explored. The method possesses some advantages such as environmentally friendly conditions, easy work-up procedure, reusability, and scalability.

Iron-Nitrate-Catalyzed Oxidative Esterification of Aldehydes and Alcohols with N-Hydroxyphthalimide: Efficient Synthesis of N-Hydroxyimide Esters

An Fe(NO3)3·9H2O-catalyzed cross-dehydrogenative coupling reaction between N-hydroxyphthalimide (NHPI) or N-hydroxysuccinimide (NHSI) and aldehydes or alcohols in air is described. This transformation represents an efficient approach to the preparation of N-hydroxyimide ester derivatives in moderate to excellent yields, and has a wide substrate scope.

Palladium-Catalyzed Carbonylation of (Hetero)Aryl, Alkenyl and Allyl Halides by Means of N-Hydroxysuccinimidyl Formate as CO Surrogate

An efficient Pd-catalyzed carbonylation protocol is described for the coupling of a large panel of aryl, heteroaryl, benzyl, vinyl and allyl halides 2 with the unusual N-hydroxysuccinimidyl (NHS) formate 1 as a CO surrogate to afford the corresponding valuable NHS esters 3. High conversion to the coupling products was achieved with up to 98% yield by means of Pd(OAc)2/Xantphos catalyst system.

General method for the preparation of active esters by palladium-catalyzed alkoxycarbonylation of aryl bromides

A useful method was developed for the synthesis of active esters by palladium-catalyzed alkoxycarbonylation of (hetero)aromatic bromides. The protocol was general for a range of oxygen nucleophiles including N-hydroxysuccinimide (NHS), pentafluorophenol (PFP), hexafluoroisopropyl alcohol (HFP), 4-nitrophenol, and N-hydroxyphthalimide. A high functional group tolerance was displayed, and several active esters were prepared with good to excellent isolated yields. The protocol was extended to access an important synthetic precursor to the HIV-protease inhibitor, saquinavir, by formation of an NHS ester followed by acyl substitution.

Cross dehydrogenative coupling (CDC) of aldehydes with N-hydroxyimides by visible light photoredox catalysis

A photoinduced cross-dehydrogenative-coupling (CDC) reaction between aldehydes and N-hydroxyimides has been developed for the synthesis of ester derivatives. Using 2 mol% [Ru(bpy)3]Cl2 in dry acetonitrile at room temperature with an LED light bulb, we were able to synthesize N-hydroxyesters in good yields. The ester derivatives are very useful synthetic intermediates, which were transformed to amide and oxazole building blocks in excellent yields. This journal is

3D-QSAR study of adamantyl N-benzylbenzamides as melanogenesis inhibitors

Three-dimensional quantitative structure-activity relationship (3D-QSAR) modeling, comparative molecular field analysis (CoMFA), and comparative molecular similarity indices analysis (CoMSIA) of polyhydroxylated N-benzylbenzamide derivatives containing an

Extremely fast gas/liquid reactions in flow microreactors: Carboxylation of short-lived organolithiums

Carboxylation of short-lived organolithiums bearing electrophilic functional groups such as nitro, cyano, and alkoxycarbonyl groups with CO 2 to give carboxylic acids and active esters was accomplished in a flow microreactor system. The successful reactions indicate that gas/liquid mass transfer and the subsequent chemical reaction with CO2 are extremely fast. Carboxylation of short-lived organolithiums bearing electrophilic functional groups such as nitro, cyano, and alkoxycarbonyl groups with CO 2 to give carboxylic acids and active esters was accomplished in a flow microreactor system. The successful reactions indicate that gas/liquid mass transfer and the subsequent chemical reaction with CO2 are extremely fast (see scheme).