5124-30-1 Usage
Description
Methylene bis (4-cyclohexylisocyanate) (HMDI) (CAS No.
5124-30-1) is a clear to pale yellow liquid, which is soluble in
acetone water and is incompatible with alcohols, amines,
bases, acids, and may slowly polymerize if heated above 50 ℃.
HMDI reacts with water and alcohol.
Chemical Properties
Different sources of media describe the Chemical Properties of 5124-30-1 differently. You can refer to the following data:
1. Liquid.Soluble in acetone;reacts with water or ethanol.
2. DMDI is a clear, colorless to light-yellow
liquid.
Uses
Different sources of media describe the Uses of 5124-30-1 differently. You can refer to the following data:
1. Methylene bis(4-cyclohexylisocyanate) isused to produce urethane foam with colorstability.
2. In the manufacture of polymers
3. HMDI has excellent light stability and the stability of the six membered ring structure, has excellent weather resistance and excellent mechanical properties of polyurethane material, and is especially suitable for the production of high performance elastic body, a water polyurethane resin and UV resin.
Definition
ChEBI: A diisocyanate consisting of dicyclohexylmethane with two isocyanate groups at the 4- and 4'-positions.
General Description
Clear colorless to light-yellow liquid.
Air & Water Reactions
Reacts with water to form CO2
Reactivity Profile
Isocyanates and thioisocyanates, such as Methylene-bis(4-cyclohexylisocyanate), are incompatible with many classes of compounds, reacting exothermically to release toxic gases. Reactions with amines, aldehydes, alcohols, alkali metals, ketones, mercaptans, strong oxidizers, hydrides, phenols, and peroxides can cause vigorous releases of heat. Acids and bases initiate polymerization reactions in these materials. Some isocyanates react with water to form amines and liberate carbon dioxide. Base-catalysed reactions of isocyanates with alcohols should be carried out in inert solvents. Such reactions in the absence of solvents often occur with explosive violence, [Wischmeyer(1969)].
Hazard
Strong skin and eye irritant. Respiratorysensitization and lower respiratory tract irritant.
Health Hazard
Studies on test animals indicate that methy-lene bis(4-cyclohexylisocyanate) is highlytoxic by an inhalation route and can causesevere skin reaction. Exposure to 20 ppmfor 5 hours produced irritation of the respiratory tract, tremor, convulsion, congestion oflungs, and edema in rats. The symptoms atlower levels were decreased as to respirationrate and pulmonary irritation.Contact with the skin can produce severeirritation, erythema, and edema. The oraltoxicity of this compound is very low.LD50 value, oral (rats): 9900 mg/kgThere is no report of the compound’smutagenicity or carcinogenicity.
Fire Hazard
Flash point data for Methylene-bis(4-cyclohexylisocyanate) are not available. Methylene-bis(4-cyclohexylisocyanate) is probably combustible.
Flammability and Explosibility
Nonflammable
Safety Profile
Poison by inhalation.
Mildly toxic by ingestion. When heated to
decomposition it emits very toxic fumes of
NOx and CN-.
Potential Exposure
A potential danger to those involved
in the manufacture of this compound or its use in the production of light-stable, nonyellowing polyurethane resins.
Environmental Fate
HMDI is a synthetic organic chemical which does not occur
naturally in the environment. At room temperature, it is
a liquid. HMDI hydrolyzes rapidly in water, producing
methylene bis(4-cyclohexylamine). The half-life for HMDI is
approximately 2 h. Due to its rapid hydrolysis, transport
between environmental compartments is unlikely to occur.
Because of the rapid hydrolysis, the assessment of the
substance is based on the hydrolysis product
methylenebis(cyclohexylamine) and not on HMDI. The
hydrolysis product was not classified as a PBT (persistent,
bioaccumulative, toxic) substance. These data indicate that
HMDI is not readily biodegradable. However, due to its rapid
hydrolysis, HMDI is neither persistent in the water compartment
nor bioaccumulative. The calculated Koc-value indicates
that HMDI may strongly adsorb to soil; however, any emission
to the terrestrial compartment would be affected by
humidity and, therefore, terrestrial accumulation is not expected
to occur.
Shipping
UN2206 Isocyanates, toxic, n.o.s. or Isocyanate
solutions, toxic, n.o.s., flash point .61C and boiling point
,300C, Hazard Class: 6.1; Labels: 6.1-Poisonous materials., Technical Name Required.
Toxicity evaluation
The toxicological properties of isocyanates are attributed to
the –N=C=O group. Skin sensitization with HMDI is
thought to be associated with the activation and proliferation
of lymphocytes in lymph nodes draining the site of
exposure. Analysis of the nature and kinetics of the cytokine
production (which regulates lymphocyte production) postexposure
to HMDI revealed that both interleukin-1 (IL-1)
and IL-6 were induced in a biphasic manner. The ordered
and transient pattern of cytokine production that occurs
during the afferent phase of contact sensitization suggests
that sequential cytokine signals may be involved in regulating
the characteristics of the response generated within
the draining lymph node.
Incompatibilities
May form explosive mixture with air.
Isocyanates are highly flammable and reactive with many
compounds, even with themselves. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause
fires or explosions. Reaction with moist air, water or alcohols
may form amines and insoluble polyureas and react exothermically, releasing toxic, corrosive or flammable gases,
including carbon dioxide; and, at the same time, may generate a violent release of heat increasing the concentration of
fumes in the air. Incompatible with amines, aldehydes, alkali
metals, ammonia, carboxylic acids, caprolactum, alkaline
materials, glycols, ketones, mercaptans, hydrides, organotin
catalysts, phenols, strong acids, strong bases, strong reducing
agents such as hydrides, urethanes, ureas. Elevated temperatures or contact with acids, bases, tertiary amines, and acylchlorides may cause explosive polymerization. Attacks some
plastics, rubber and coatings. Contact with metals may evolve
flammable hydrogen gas. May accumulate static electrical
charges, and may cause ignition of its vapors. May slowly
polymerize if heated above 122F/50C. Contact with metals
may evolve flammable hydrogen gas.
Waste Disposal
Methylene bis(4-cyclohexylisocyanate) isdissolved in acetone or any other combustible solvent and burned in a chemicalincinerator equipped with an afterburner andscrubber.
Check Digit Verification of cas no
The CAS Registry Mumber 5124-30-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,1,2 and 4 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 5124-30:
(6*5)+(5*1)+(4*2)+(3*4)+(2*3)+(1*0)=61
61 % 10 = 1
So 5124-30-1 is a valid CAS Registry Number.
5124-30-1Relevant articles and documents
METHOD FOR PRODUCING CARBAMATE AND METHOD FOR PRODUCING ISOCYANATE
-
Paragraph 0367; 0369-0379; 0399; 0402-0403, (2021/06/22)
The present invention provides a method for producing a carbamate that includes a step (1) and a step (2) described below: (1) a step of producing a compound (A) having a urea linkage, using an organic primary amine having at least one primary amino group per molecule and at least one compound selected from among carbon dioxide and carbonic acid derivatives, at a temperature lower than the thermal dissociation temperature of the urea linkage; and(2) a step of reacting the compound (A) with a carbonate ester to produce a carbamate.
Preparation method of 4,4'-dicyclohexyl methane diisocyanate
-
Paragraph 0027-0060, (2019/10/01)
The invention relates to a preparation method of 4,4'-dicyclohexyl methane diisocyanate. The method comprises the steps of firstly, adding a catalyst polyoxometallate and a solvent into a reaction vessel; then, adding a raw material of 4,4'-diamino dicyclohexyl methane, phenylsilane, an acid-binding agent and a dehydrating agent, and uniformly mixing the materials; finally, adding gaseous carbon dioxide and stirring the mixture for a thorough reaction through a magnetic force at a certain temperature to obtain a product. According to the method, M-Anderson type heteropoly acid is used as the catalyst, and the catalyst needs mild reaction conditions and is high in specific selectivity, recyclable and environmentally friendly; the cleanliness of an industrial reaction is improved, the economic efficiency of the process is improved, the manufacturing cost and the generation of three wastes are reduced, the environmental protection pressure is reduced, and industrial production is facilitated.
Method for preparing isocyanate by using amine and carbonyl fluoride
-
Paragraph 0095-0096, (2017/07/07)
The invention discloses an efficient synthesis method for preparing corresponding isocyanate by enabling carbonyl fluoride to directly react with amine. The efficient synthesis method mainly comprises the following two steps: carrying out acylation reaction on the amine and the carbonyl fluoride according to a preferable proportion in an anhydrous inertial organic solvent under a sealed environment and a proper reaction condition, thus generating an intermediate-carbamyl fluoride; (2) carrying out dehydrofluorination on the intermediate-carbamyl fluoride under normal pressure and the proper reaction condition, thus obtaining the target isocyanate. During a reaction process, addition of a catalyst is not needed, the reaction conditions are mild, excessive carbonyl fluoride and a used solvent during the reaction process can be efficiently recycled and reused, and a by-product HF can be commercially sold after being collected and refined.
