5131-59-9

Usage

Uses

Used in Pharmaceutical Applications:
2,4,8-trichlorophenanthridin-6(5H)-one is used as a potential antitumor agent for its ability to inhibit DNA topoisomerase I, which is an enzyme involved in DNA replication. This inhibition can lead to the disruption of cancer cell growth and proliferation.
Used in Antimicrobial Applications:
2,4,8-trichlorophenanthridin-6(5H)-one is used as an antimicrobial agent due to its potential to combat bacterial and fungal infections. Its effectiveness against various pathogens makes it a candidate for further development in the field of infectious disease treatment.
Used in Antifungal Applications:
2,4,8-trichlorophenanthridin-6(5H)-one is used as an antifungal agent, targeting fungal pathogens that can cause infections in humans and other organisms. Its potential to inhibit fungal growth and development makes it a promising candidate for antifungal drug development.
Used in Photodynamic Therapy:
2,4,8-trichlorophenanthridin-6(5H)-one is used as a photosensitizer in photodynamic therapy for cancer treatment. When exposed to light of a specific wavelength, 2,4,8-trichlorophenanthridin-6(5H)-one can generate reactive oxygen species that can selectively kill cancer cells, making it a potential tool in the fight against cancer.
Used in Research and Development:
2,4,8-trichlorophenanthridin-6(5H)-one is used as a research compound for further investigation into its pharmacological properties and potential applications. Its diverse range of activities makes it an interesting subject for scientific exploration and potential drug development.

Upstream product

• 620-81-5 N,N'-Diphenyloxamid 
• 7697-37-2 nitric acid 
• 144-62-7 oxalic acid 
• 64-19-7 acetic acid 
• 6067-45-4 4,4'-dinitrobenzil 
• 578-66-5 8-amino quinoline 
• 79-37-8 oxalyl dichloride 
• 100-01-6 4-nitro-aniline 
• 24424-99-5 di-tert-butyl dicarbonate 
• 57736-09-1 4.4'-dinitro-benzil-mono-seqcis-oxime 
• 39809-82-0 N,N'-bis-(4-nitrophenyl)methanediamine 
• 95-92-1 oxalic acid diethyl ester 
• 43084-63-5 4.4'-dinitro-benzil-di-seqcis-oxime 

Downstream Products

• 19532-78-6 N,N'-bis-(4-amino-phenyl)-oxalamide 
• 109735-70-8 bis(4-nitrophenylimidoyl)chloride 

Relevant academic research and scientific papers

Fine tuning of receptor polarity for the development of selective naked eye anion receptor

We designed and synthesized new anion receptors 1, 2, and 3, which have different N-H polarity. According to their N-H polarities, these receptors showed different selectivities for the anions they were interacting with. The difference of selectivity coul

Synthesis of N,N′-diarylalkanediamides and their antimycobacterial and antialgal activity

A set of N,N′-diarylalkanediamides was synthesized. The compounds were tested for their antimycobacterial and antialgal activity. The antimycobacterial activity of N,N′-diarylalkanediamides depends on the lipophilicity of the respective acid. Antimycobacteri-ally active substances were found only in the series of N,N′-diarylethanediamides and N,N′-diarylbutanediamides. Other compounds (derivatives of pentane-, hexane-, octane- and nonanediamide) were inactive against various strains of mycobacteria. The compounds inhibited growth and chlorophyll production in Chlorella vulgaris. Their relatively low antial-gal activity is probably connected with their lowered aqueous solubility, and hence by a restricted passage of the inhibitor through the hydrophilic regions of thylakoid membranes.

Heterocycles from Heterocycles. 1,3-Diaryl-4,5-imidazolidinediones from 1,3,5-Triarylhexahydro-1,3,5-triazines and Oxalyl Chloride

1,3-Diaryl-4,5-imidazolidinediones (6) are easily synthesized from 1,3,5-triarylhexahydro-1,3,5-triazines (1) and oxalyl chloride (5) in a reaction not likely to involve the zwitterionic intermediate (3) of the N-methylenearylamine dimer, but viewing the sequential pick up of two units of the monomer (2) by oxalyl chloride (5).The essential role of ethyl alcohol added to the reaction mixture is recognized.Reaction conditions have been optimized and some ten imidazolidinediones (6) were prepared in good to excellent yields.Geometric parameters of 6 were obtained by X-ray diffraction analysis: all the nuclei are found almost in one plane except for a small twist of the phenyl rings about the C-N bond.