620-81-5

Usage

Uses

Used in Pharmaceutical Industry:
Oxanilide is used as a key intermediate in the synthesis of various pharmaceuticals, particularly in the development of antiviral and antimalarial drugs. Its ability to form metal complexes with specific properties makes it a valuable component in the creation of new and effective medications.
Used in Chemical Synthesis:
Oxanilide is used as a bidentate ligand in the synthesis of metal complexes. This application is crucial in various chemical processes, as the metal complexes formed can exhibit unique properties and reactivity, leading to the development of new materials and catalysts.

Upstream product

• 56-23-5 tetrachloromethane 
• 3155-16-6 diphenyl oxalate 
• 622-14-0 N,N'-diphenylmethylenediamine 
• 4746-61-6 glycolanilide 
• 79-37-8 oxalyl dichloride 
• 142-04-1 aniline hydrochloride 
• 4208-40-6 2-methylene-3-phenyl-oxazolidine-4,5-dione 
• 62-53-3 aniline 
• 871889-28-0 methyl-piperazinetetraone 
• 64-17-5 ethanol 
• 17843-00-4 phenyl-oxalomonoimidic acid dianilide 
• 13532-81-5 glyoxime-N_.N'-diphenyl ether 
• 108-24-7 acetic anhydride 
• 64-19-7 acetic acid 

Downstream Products

• 6333-34-2 NN'-(4,4'-dichlorodiphenyl)oxamide 
• 17772-31-5 N,N'-bis-(2,4-dichloro-phenyl)-oxalamide 
• 20033-74-3 bis(phenylimidoyl)chloride 
• 6244-74-2 N,N'-diphenyldithiooxamide 
• 78121-70-7 N,N'-diphenylthiooxamide 
• 5131-59-9 N,N'-bis-(4-nitro-phenyl)-oxalamide 
• 500-72-1 oxanilic acid 
• 29135-62-4 N,N'-dipicryl-oxalamide 
• 21022-25-3 N¹,N²-bis(4-bromophenyl)oxalamide 
• 14805-54-0 N,N'-bis(2,4-dinitrophenyl)oxamide 
• 103-71-9 phenyl isocyanate 
• 88-74-4 2-nitro-aniline 
• 102-07-8 bis(diphenyl)urea 
• 121-57-3 4-aminobenzene sulfonic acid 

Relevant academic research and scientific papers

Copper-Catalyzed Ullmann-Type Coupling and Decarboxylation Cascade of Arylhalides with Malonates to Access α-Aryl Esters

We have developed a high-efficiency and practical Cu-catalyzed cross-coupling to directly construct versatile α-aryl-esters by utilizing readily available aryl bromides (or chlorides) and malonates. These gram-scale approaches occur with turnovers of up to 1560 and are smoothly conducted by the usage of a low catalyst loading, a new available ligand, and a green solvent. A variety of functional groups are tolerated, and the application occurs with α-aryl-esters to access nonsteroidal anti-inflammatory drugs (NSAIDs) on the gram scale.

Tuning the Reactivity of Cofacial Porphyrin Prisms for Oxygen Reduction Using Modular Building Blocks

We assembled eight cofacial porphyrin prisms using MTPyP (M = Co(II) or Zn(II), TPyP = 4-tetrapyridylporphyrin) and functionalized ruthenium-based "molecular clips"using coordination-driven self-assembly. Our approach allows for the rapid synthesis of these architectures in isolated yields as high as 98% for the assembly step. Structural and reactivity studies provided a deeper understanding of the role of the building blocks on the oxygen reduction reaction (ORR). Catalytic efficacy was probed by using cyclic and hydrodynamic voltammetry on heterogeneous catalyst inks in aqueous media. The reported prisms showed outstanding selectivity (>98%) for the kinetically hindered 4e-/4H+ reduction of O2 to H2O over the kinetically more accessible 2e-/2H+ reduction to H2O2. Furthermore, we have demonstrated significant cofacial enhancement in the observed catalytic rate constant ks (μ5 orders of magnitude) over the mononuclear analogue. We conclude that the steric bulk of the clip plays an important role in the structural dynamics of these prisms, which in turn modulates the ORR reactivity with respect to selectivity and kinetics.

Visible-light-induced direct construction of amide bond from carboxylic acids with amines in aqueous solution

A novel visible-light-promoted N-acylation for the synthesis of amides from easily available carboxylic acids with amines in the presence of I2 within 2.5 h in aqueous solution has been developed. Using sunlight as the visible light source greatly reduces the cost of experiments and produces almost no toxic effects. Hence, this study provides an alternative catalytic system for the construction of a wide range of amides with readily available materials. Moreover, the strategy was successfully applied in the preparation of N-(3-(2,6-dimethoxyphenoxy)-7-nitroquinoxalin-2-yl)benzohydrazide, which displayed a signification anti-proliferation effect on A549, MCF-7 and HCT116 cell lines.

Synthesis of oxalamides by acceptorless dehydrogenative coupling of ethylene glycol and amines and the reverse hydrogenation catalyzed by ruthenium

A sustainable, new synthesis of oxalamides, by acceptorless dehydrogenative coupling of ethylene glycol with amines, generating H2, homogeneously catalyzed by a ruthenium pincer complex, is presented. The reverse hydrogenation reaction is also accomplished using the same catalyst. A plausible reaction mechanism is proposed based on stoichiometric reactions, NMR studies, X-ray crystallography as well as observation of plausible intermediates.

Preparation method of oxamide

The invention provides a preparation method of oxamide. The preparation method comprises the following steps: an intermediate oxamide derivative is prepared from CO, O2 and amine compounds as raw materials by oxidation and carbonylation under the action of a catalyst 1, and then, oxamide is prepared through aminolysis of the oxamide derivative under the action of a catalyst 2. A novel method is used for coproducing oxamide and the oxamide derivative, and the problems that oxalate synthesis materials are poisonous, catalyst efficiency is low and the like in the original technology for synthesizing oxamide through aminolysis of oxalate are solved. Besides, the technologically synthesized oxamide derivative has good substrate applicability and can be applied to fields of medicine, pesticides,synthetic ligands, food additives and the like.

Theoretical and Experimental Studies: Cu(I)/Cu(II) Catalytic Cycle in CuI/Oxalamide-Promoted C-N Bond Formation

In modern Ullmann-Goldberg reactions, cheaper aryl chlorides are poor substrates. Recently, attention has been paid to facile CuI/oxalamide-promoted arylation of heteroatoms (N, O, and S) using cheaper aryl chlorides. However, the mechanism of the reaction and the role of oxalamides have not yet been investigated. In the present investigation, theoretical (density functional theory) and supporting in situ 1H NMR spectroscopy, UV-vis spectroscopy, Fourier transform infrared spectroscopy, and cyclic voltammetry studies have been performed to provide insight into the various aspects of the mechanism. Five different possible pathways have been investigated. [LCu(NHNu)] is the active copper catalytic species, in which L (oxalamide) coordinates Cu(I) through both C=O groups. Our studies show that the reaction follows an outer-sphere single-electron transfer pathway. Moreover, these studies also address the reason for the deactivation of a copper catalyst.

DIKETOPYRROLOPYRROLE PIGMENT COMPOSITION AND COLORING COMPOSITION BASED ON THAT DIKETOPYRROLOPYRROLE PIGMENT COMPOSITION

PROBLEM TO BE SOLVED: To provide: a diketopyrrolopyrrole pigment composition allowing control of the color tone more economically and freely; and a coloring composition based on the diketopyrrolopyrrole pigment composition. SOLUTION: A diketopyrrolopyrrole pigment composition comprises a diketopyrrolopyrrole pigment represented by general formula (1) and an aromatic amide compound represented by general formula (2). In the diketopyrrolopyrrole pigment composition, the diketopyrrolopyrrole pigment may be represented by general formula (3). SELECTED DRAWING: Figure 1 COPYRIGHT: (C)2019,JPOandINPIT

Palladium-Catalyzed Modular Synthesis of Substituted Piperazines and Related Nitrogen Heterocycles

We report here a novel method for the modular synthesis of highly substituted piperazines and related bis-nitrogen heterocycles via a palladium-catalyzed cyclization reaction. The process couples two of the carbons of a propargyl unit with various diamine components to provide nitrogen heterocycles in generally good to excellent yields and high regio- and stereochemical control. (Chemical Equation Presented).

Solvent free, highly chemoselective N and O-acylation on silica and silica magnesium oxide: A recyclable solid surface

Silica or silica/magnesium oxide mixed surface mediates the N and O-acylation, benzoylation or sulfonylation of hosts of substrates under solvent free conditions at ambient temperature with high chemoselectivity.

ZnO nanofluid as a structure base catalyst for chemoselective amidation of aliphatic carboxylic acids

ZnO nanofluids were synthesized and utilized as a new reaction media in the preparation of amides via direct amidation of aliphatic carboxylic acids with primary amines under solvent-free conditions. High yields and good selectivity are achieved with this psudo-homogeneous catalyst, while the recovered nanoZnO was reusable.