515883-91-7

Basic information

• Product Name: 4-amino-5-[1-(4-isobutylphenyl)ethyl]-3-mercapto-(4H)-1,2,4-triazole
• Synonyms: 4-amino-5-[1-(4-isobutylphenyl)ethyl]-3-mercapto-(4H)-1,2,4-triazole
• CAS NO: 515883-91-7
• Molecular Weight: 276.406
• Mol File: 515883-91-7.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 4-amino-5-[1-(4-isobutylphenyl)ethyl]-3-mercapto-(4H)-1,2,4-triazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-amino-5-[1-(4-isobutylphenyl)ethyl]-3-mercapto-(4H)-1,2,4-triazole(515883-91-7)
• EPA Substance Registry System: 4-amino-5-[1-(4-isobutylphenyl)ethyl]-3-mercapto-(4H)-1,2,4-triazole(515883-91-7)

Safety Data

• Hazardous Substances Data: 515883-91-7(Hazardous Substances Data)

Upstream product

• 15687-27-1 ibuprofen 
• 127222-69-9 ibuprofen hydrazide 
• 41283-72-1 ibuprofen ethyl ester 
• 2231-57-4 Thiocarbohydrazide 
• 75-15-0 carbon disulfide 

Downstream Products

• 1394248-95-3 3-[1-(4-isobutylphenyl)ethyl]-4-[3-(p-anisyl)-4-sydnonylidene]amino-5-mercapto-1,2,4-triazole 
• 1394249-06-9 1-piperidinomethyl-3-[1-(4-isobutylphenyl)ethyl]-4-[3-(p-anisyl)-4-sydnonylidene]amino-1,2,4-triazol-5-thione 
• 1394249-02-5 1-piperidinomethyl-3-[1-(4-isobutylphenyl)ethyl]-4-[3-(ptolyl)-4-sydnonylidene]amino-1,2,4-triazol-5-thione 
• 1394248-99-7 1-N-ethyl-piperazinomethyl-3-[1-(4-isobutylphenyl)ethyl]-4-(3-phenyl-4-sydnonylidene)amino-1,2,4-triazol-5-thione 
• 1394248-97-5 1-piperidinomethyl-3-[1-(4-isobutylphenyl)ethyl]-4-(3-phenyl-4-sydnonylidene)amino-1,2,4-triazol-5-thione 
• 1394248-96-4 1-morpholinomethyl-3-[1-(4-isobutylphenyl)ethyl]-4-(3-phenyl-4-sydnonylidene)amino-1,2,4-triazol-5-thione 
• 515883-93-9 6-(2-chlorophenyl)-3-[1-(4-isobutylphenyl)ethyl]-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 
• 1277163-43-5 3-[1-(4-isobutylphenyl)ethyl]-6-propyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 
• 1277163-42-4 6-ethyl-3-[1-(4-isobutylphenyl)ethyl]-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 
• 1262528-13-1 3-[1-(4-isobutylphenyl)ethyl]-6-methyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 
• 1277163-46-8 6-(4-bromophenyl)-3-[1-(4-isobutylphenyl)ethyl]-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 
• 1277163-44-6 6-(2-furyl)-3-[1-(4-isobutylphenyl)ethyl]-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 
• 1187071-18-6 C₂₁H₂₃BrN₄S 

Relevant articles and documents

Non-carboxylic analogues of arylpropionic acids: Synthesis, anti-inflammatory activity and ulcerogenic potential

Two series of 1,2,4-triazoles and 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles derived from three selected arylpropionic acids namely, ibuprofen, flurbiprofen and naproxen, were synthesized and evaluated for anti-inflammatory activity and ulcerogenic potentia

Synthesis and Evaluation of Some Phenyl Substituted Azetidine Containing 1, 2, 4-triazole Derivatives as Antibacterial Agents

A novel series of phenyl substituted azetidine containing 1, 2, 4-triazole derivatives 7(a–j) were synthesized and characterized by IR, 1HNMR, 13CNMR, and mass spectroscopy. Synthesized 1, 2, 4-triazole derivatives were subsequently assayed in vitro to investigate their antibacterial activity against Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli using broth dilution method. Compounds 7c, 7d, and 7e exhibited potent inhibitory activities as compared to standard cefotaxime. Further, fluorescence spectral studies were also carried out to ascertain the antibacterial potential of compound 7c against two bacterial strains, that is, P.?aeruginosa and S.?aureus. In docking studies, all the compounds exhibited good docking scores between ?12.04 and ?11.36?kcal/mol and indicated that compounds could act through inhibition of bacterial DNA gyrase (PDB ID 3U2D). Among all, 7c has shown the maximum docking score and found in agreement to in vitro studies. In conclusion, synthesized 1, 2, 4-triazole derivatives holds substantial caliber to be categorized as antibacterial agents.

Regioselective reaction: Synthesis, characterization and pharmacological activity of some new Mannich and Schiff bases containing sydnone

A novel series of 1-substituted aminomethyl-3-[1-(4-isobutylphenyl)ethyl]- 4-(3-aryl-4-sydnonylidene) amino-1,2,4-triazol-5-thiones (9), was prepared from the 3-[1-(4-isobutylphenyl)ethyl]-4-(3-aryl-4-sydnonylidene) amino 5-mercapto-1,2,4-triazoles (8) by aminomethylation with formaldehyde and secondary amine. The structures of Schiff bases (8) and Mannich bases (9) were characterized on the basis of IR, NMR, mass spectra1 data and elemental analysis. The newly synthesized compounds were screened for their anti-inflammatory and analgesic activities. Mannich bases (9) carrying piperidine and morpholine residues showed promising anti-inflammatory and analgesic activity.