52727-62-5

Usage

Uses

Used in Pharmaceutical and Chemical Research:
METHYL 2-AMINO-3,5-DICHLOROBENZOATE is utilized as a key building block for the synthesis of various drugs and organic compounds, contributing to the development of new therapeutic agents and chemical products.
Used in Agrochemical Production:
In the agrochemical industry, METHYL 2-AMINO-3,5-DICHLOROBENZOATE serves as an intermediate in the manufacturing process, playing a crucial role in the creation of effective and safe agricultural chemicals.
Used in Dye Manufacturing:
METHYL 2-AMINO-3,5-DICHLOROBENZOATE is also employed in the production of dyes, where its unique chemical structure contributes to the development of novel colorants for various applications.
Used in Biological Research and Therapeutic Applications:
METHYL 2-AMINO-3,5-DICHLOROBENZOATE has been studied for its potential biological activities, which may lead to therapeutic applications, highlighting its versatility and value in the scientific community.

Upstream product

• 134-20-3 2-carbomethoxyaniline 
• 7647-01-0 hydrogenchloride 
• 7782-50-5 chlorine 
• 64-19-7 acetic acid 
• 67-56-1 methanol 
• 2789-92-6 3,5-dichloroantranilic acid 
• 6374-92-1 5,7-dichloroisatin 

Downstream Products

• 111532-15-1 (2-amino-3,5-dichloro-phenyl)-diphenyl-methanol 
• 2789-92-6 3,5-dichloroantranilic acid 
• 109395-59-7 2,4-dichloro-9-phenyl-acridine 
• 500008-47-9 1-(3-chloropyridine-2-yl)-3-bromo-N-(2,4-dichloro-6-tert-butylaminocarbonyl)phenyl-1H-pyrazole-5-formamide 
• 66788-81-6 2-acetylamino-3,5-dichloro-benzoic acid methyl ester 
• 929710-54-3 3,5-dichloro-2-amino-N-(2-hydroxyethoxy)benzamide 

Relevant academic research and scientific papers

Optimization of a binding fragment targeting the “enlarged methionine pocket” leads to potent Trypanosoma brucei methionyl-tRNA synthetase inhibitors

Potent inhibitors of Trypanosoma brucei methionyl-tRNA synthetase were previously designed using a structure-guided approach. Compounds 1 and 2 were the most active compounds in the cyclic and linear linker series, respectively. To further improve cellular potency, SAR investigation of a binding fragment targeting the “enlarged methionine pocket” (EMP) was performed. The optimization led to the identification of a 6,8-dichloro-tetrahydroquinoline ring as a favorable fragment to bind the EMP. Replacement of 3,5-dichloro-benzyl group (the EMP binding fragment) of inhibitor 2 using this tetrahydroquinoline fragment resulted in compound 13, that exhibited an EC50 of 4?nM.

POLYSUBSTITUTED PYRIDYL PYRAZOLECARBOXAMIDE AND PREPARATION METHOD AND USE THEREOF

The present invention discloses a polysubstituted pyridyl pyrazolecarboxamide and its preparation method and use. The structure of the polysubstituted pyridyl pyrazolecarboxamide of the present invention is shown in the following General Formula I. The po

Synthesis of 2,6-disubstituted and 2,3,6-trisubstituted anilines

A number of 2,6-disubstituted and 2,3,6-trisubstituted anilines have been prepared via the selective para dehalogenation of the corresponding anilines. Modification of the substituents on the amino nitrogen demonstrates that the selectivity is derived from steric rather than electronic effects. The effects of the choice of formate hydrogen donor, Pd catalyst, solvent, and temperature upon the efficiency and selectivity of the dehalogenation are discussed.

Process for the selective reduction of the 4-halogen in 2,4-dihaloanilines

Substituted 2-haloanilines are prepared from the correspondingly substituted 2,4-dichloro- or 2,4-dibromoanilines by selectively reducing a chloro or bromo substituent para to a protected amino group in the presence of the same halogen as an ortho substit