52787-20-9

Basic information

• Product Name: Benzeneacetic acid, 3-(methoxycarbonyl)-, methyl ester
• CAS NO: 52787-20-9
• Molecular Formula: C11H12O4
• Molecular Weight: 208.214
• Mol File: 52787-20-9.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Benzeneacetic acid, 3-(methoxycarbonyl)-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetic acid, 3-(methoxycarbonyl)-, methyl ester(52787-20-9)
• EPA Substance Registry System: Benzeneacetic acid, 3-(methoxycarbonyl)-, methyl ester(52787-20-9)

Safety Data

• Hazardous Substances Data: 52787-20-9(Hazardous Substances Data)

Upstream product

• 121-92-6 3-nitrobenzoic acid 
• 618-95-1 methyl 3-nitrobenzoate 
• 96-34-4 methyl chloroacetate 
• 52798-00-2 (3-cyano-phenyl)-acetic acid methyl ester 
• 1878-67-7 3-Bromophenylacetic acid 
• 150529-73-0 methyl 2-(3-bromophenyl)acetatee 
• 16532-78-8 3-(cyanomethyl)benzonitrile 
• 67-56-1 methanol 
• 68432-92-8 methyl 3-cyanomethylbenzoate 
• 124-41-4 sodium methylate 
• 203805-67-8 8-Oxo-bicyclo[4.2.0]octa-1⁽⁶⁾,2,4-triene-2-carboxylic acid methyl ester 
• 2084-13-1 3-carboxymethyl-benzoic acid 

Downstream Products

• 4866-86-8 3-(2-hydroxyethyl)benzyl alcohol 
• 52787-21-0 (3-hydrazinocarbonyl-phenyl)-acetic acid 
• 52787-24-3 (3-[1,3,4]oxadiazol-2-yl-phenyl)-acetic acid 
• 52787-26-5 [3-(5-ethyl-[1,3,4]oxadiazol-2-yl)-phenyl]-acetic acid 
• 1429653-88-2 methyl 3-(2-((2-((tert-butyldimethylsilyl)oxy)ethyl)(phenyl)amino)-2-oxoethyl)benzoate 
• 1446499-66-6 3-(2-((2-((tert-butyldimethylsilyl)oxy)ethyl)(phenyl)amino)-2-oxoethyl)-N-hydroxybenzamide 
• 1429652-59-4 N-hydroxy-3-(2-((2-hydroxyethyl)(phenyl)amino)-2-oxoethyl) benzamide 
• 752984-74-0 4-amino-5-{3-[2-(p-toluenesulfonyloxy)ethyl]benzyl}-2-methylpyrimidine 
• 752984-71-7 4-amino-5-[3-(2-hydroxyethyl)benzyl]-2-methylpyrimidine 
• 212914-87-9 3-(2-hydroxyethyl)benzaldehyde 
• 52787-19-6 2-(3-(methoxycarbonyl)phenyl) acetic acid 

Relevant articles and documents

Indole ketone compound or its derivatives and their use

The present invention relates to indolone compounds shown by general formula (a) or derivatives thereof, and uses thereof. The technical problem solved by the present invention is to provide indolone compounds or derivatives thereof, and uses thereof. The present invention uses a deuterium-enriched indolone compound obtained from a deuterium-substituted indolone compound. The above-mentioned indolone compounds can simultaneously effect on three key receptor families involved in the process of blood vessel formation, i.e., vascular endothelial growth factor receptor (VEGFR), fibroblast growth factor receptor (FGFR), and platelet-derived growth factor receptor (PDGFR), and inhibit the formation of blood vessel, thereby achieving the effect of treating cancers. The above-mentioned deuterium-substituted indolone compounds or derivatives thereof have the advantage of high efficiency as medicaments.

NOVEL MOLECULES THAT SELECTIVELY INHIBIT HISTONE DEACETYLASE 6 RELATIVE TO HISTONE DEACETYLASE 1

The compounds of the present invention are HDAC6 selective inhibitors which are identified on the basis of accumulation of acetylated tubulin without accumulation of acetylated histones. Histone deacetylase or "HDAC" refers to enzymes capable of cleaving an acetyl group (-C(=0)CH3) from proteins, including histone and microtubulins. Compositions comprising the molecules and methods for their use to inhibit the activity of histone deacetylase, including for treatment, are also disclosed.

A simple method for the preparation of monomethyl esters of dicarboxylic acids by selective esterification of the nonconjugated carboxyl group in the presence of an aromatic or conjugated carboxyl group

Various dicarboxylic acids have been converted selectively into monomethyl esters in which the nonconjugated carboxyl group is selectively esterified in the presence of an aromatic or conjugated carboxyl group at room temperature (~ 25-27°C) in methanol using a catalytic amount of thionyl chloride.