2084-13-1

Basic information

• Product Name: 3-(carboxymethyl)benzoic acid
• Synonyms: 3-(carboxymethyl)benzoic acid;(3-Carboxyphenyl)acetic acid;Homoisophthalic acid;BENZENEACETIC ACID, 3-CARBOXY-;3-(Carboxymethyl)
• CAS NO: 2084-13-1
• Molecular Formula: C₉H₈O₄
• Molecular Weight: 180.16
• Mol File: 2084-13-1.mol
• Article Data: 6

Chemical Properties

• Melting Point: 185 °C
• Boiling Point: 412.8°Cat760mmHg
• Flash Point: 217.6°C
• Appearance: /
• Density: 1.392g/cm³
• Vapor Pressure: 1.48E-07mmHg at 25°C
• Refractive Index: 1.6
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.13±0.10(Predicted)
• CAS DataBase Reference: 3-(carboxymethyl)benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(carboxymethyl)benzoic acid(2084-13-1)
• EPA Substance Registry System: 3-(carboxymethyl)benzoic acid(2084-13-1)

Safety Data

• Hazardous Substances Data: 2084-13-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H8O4/c10-8(11)5-6-2-1-3-7(4-6)9(12)13/h1-4H,5H2,(H,10,11)(H,12,13)

Upstream product

• 52798-00-2 (3-cyano-phenyl)-acetic acid methyl ester 
• 1878-67-7 3-Bromophenylacetic acid 
• 150529-73-0 methyl 2-(3-bromophenyl)acetatee 
• 68432-92-8 methyl 3-cyanomethylbenzoate 
• 1129-28-8 3-methoxycarbonylbenzyl bromide 
• 5689-33-8 ethyl 3-cyanomethylbenzoate 
• 101-97-3 Ethyl 2-phenylethanoate 
• 14194-05-9 ethyl 2-(3-acetylphenyl)acetate 
• 124-38-9 carbon dioxide 
• 1822-71-5 n-pentylsodium 
• 108-88-3 toluene 
• 111-65-9 octane 
• 201230-82-2 carbon monoxide 
• 28188-41-2 m-(bromomethyl)benzonitrile 

Downstream Products

• 6553-12-4 bicyclo[3.2.1]octan-6-one 
• 1416319-77-1 meta-Ar-CDM-COCl 
• 1416319-76-0 meta-Ar-CDM-CO₂H 
• 1429653-88-2 methyl 3-(2-((2-((tert-butyldimethylsilyl)oxy)ethyl)(phenyl)amino)-2-oxoethyl)benzoate 
• 1446499-66-6 3-(2-((2-((tert-butyldimethylsilyl)oxy)ethyl)(phenyl)amino)-2-oxoethyl)-N-hydroxybenzamide 
• 1429652-59-4 N-hydroxy-3-(2-((2-hydroxyethyl)(phenyl)amino)-2-oxoethyl) benzamide 
• 113496-14-3 methyl 3-carboxyphenyl acetate 
• 509093-57-6 3-methanesulfonyl-N-(1-(2-morpholin-4-yl-ethyl)-1H-benzoimidazol-2-yl)-benzamide 
• 81936-02-9 3-[1-carboxy-2-(3-methoxy-phenyl)-ethyl]-benzoic acid 
• 105904-83-4 (3-dimethylaminomethyl-phenethyl)-dimethyl-amine 
• 52787-19-6 2-(3-(methoxycarbonyl)phenyl) acetic acid 
• 155938-46-8 [3-(4-Oxo-4H-chromen-2-yl)-phenyl]-acetic acid hexadecyl ester 
• 155938-45-7 [3-(4-Oxo-4H-chromen-2-yl)-phenyl]-acetic acid octyl ester 
• 155938-29-7 [3-(5,7-Dimethyl-4-oxo-4H-chromen-2-yl)-phenyl]-acetic acid ethyl ester 

Relevant articles and documents

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The invention belongs to the technical field of pyridineacetamide derivatives, and particularly relates to a pyridineacetamide derivative serving as a CDK inhibitor and a preparation method and application of the pyridine acetamide derivative. The pyridineacetamide derivative shows excellent CDK9/CDK7 enzyme inhibitory activity, and can be used for preparing drugs used for treating cancers, especially hematologic cancers including acute myeloid leukemia, multiple myeloma, chronic lymphocytic leukemia, follicular lymphoma and the like and solid tumors such as breast cancer, prostate cancer, ovarian cancer, hepatocellular carcinoma, pancreatic cancer, kidney cancer, stomach cancer, colorectal cancer, lung cancer and the like.

DISUBSTITUTED MALEIC ANHYDRIDES WITH ALTERED KINETICS OF RING CLOSURE

We describe anhydride compounds suitable for physiologically labile modification of amine- containing molecules. The described anhydrides form reversible linkages having desirable kinetics for in vivo delivery of biologically active molecules. Also described are endosomolytic polymers formed by modification of membrane active polyamines with the described anhydrides.

EP2 RECEPTOR AGONISTS

A compound of Formula (I) or a salt, solvate and chemically protected form thereof, wherein: R5 is an optionally substituted C5-20 aryl or C4-20 alkyl group; A is selected from the group consisting of Formulae (Ai), (Aii), (Aiii) D is selected from Formulae (Di), (Dii), (Diii), (Div), (Dv) B is selected from the group consisting of Formulae (Bi), (Bii), (Biii), (Biv) (Bv).