53146-34-2

Basic information

• Product Name: 1-methoxy-3-(propan-2-yloxy)propan-2-ol
• CAS NO: 53146-34-2
• Molecular Formula: C₇H₁₆O₃
• Molecular Weight: 148.2001
• Mol File: 53146-34-2.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 203.3°C at 760 mmHg
• Flash Point: 76.7°C
• Density: 0.955g/cm³
• Vapor Pressure: 0.0678mmHg at 25°C
• Refractive Index: 1.422
• CAS DataBase Reference: 1-methoxy-3-(propan-2-yloxy)propan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-methoxy-3-(propan-2-yloxy)propan-2-ol(53146-34-2)
• EPA Substance Registry System: 1-methoxy-3-(propan-2-yloxy)propan-2-ol(53146-34-2)

Safety Data

• Hazardous Substances Data: 53146-34-2(Hazardous Substances Data)

Usage

Molar mass

188.25 g/mol

Physical state

Colorless, odorless liquid

Solubility

Soluble in water

Taste

Slightly sweet

Primary use

Expectorant in cough medicines

Functionality

Helps loosen and thin mucus in the airways

Benefits

Easier to cough up and clear the lungs

Additional effects

Mild sedative effects

Application

Relieve symptoms of cough and chest congestion

Industries

Pharmaceutical

Safety

Generally regarded as safe when used as directed

Upstream product

• 4016-14-2 glycidyl isopropyl ether 
• 67-56-1 methanol 
• 124-41-4 sodium methylate 
• 4151-97-7 1-chloro-3-methoxypropan-2-ol 
• 67-63-0 isopropyl alcohol 
• 930-37-0 glycidyl methyl ether 

Relevant articles and documents

Readily Scalable Methodology for the Synthesis of Nonsymmetric Glyceryl Diethers by a Tandem Acid-/Base-Catalyzed Process

A useful optimized synthetic methodology has been designed for the synthesis of nonsymmetric glyceryl diethers from epichlorohydrin. A tandem process combining a cheap, heterogeneous, and fully recoverable acid catalyst and alkaline hydroxide is used for the synthesis of a variety of glycerol-derived ethers bearing different alkyl substituents in 1 and 3 positions. Different heterogeneous acid catalysts have been tested for the reaction of epichlorohydrin with several alcohols, the best results being obtained with readily available recoverable and inexpensive montmorillonite-K10 and Nafion NR50. For the second reaction step, potassium hydroxide is used. In all the cases, good yields of the desired glyceryl diethers are obtained in smooth reaction conditions, always with total conversion of epichlorohydrin and without the need of intermediate purification. Scale-up of the tandem process has been carried out with good results.

An Fe3O4 nanoparticle-supported Mn (II)-azo Schiff complex acts as a heterogeneous catalyst in alcoholysis of epoxides

In this paper, an azo-containing Schiff base complex of manganese [Mn2+-azo ligand@APTES-SiO2@Fe3O4] immobilized on chemically modified Fe3O4 nanoparticles has been used as a magnetically retrievable catalyst for the alcoholysis of different epoxides to their corresponding alkoxy alcohols with methanol, ethanol and n-propanol. The newly magnetic nanoparticles (MNPs) were characterized by Fourier transform infrared spectroscopy (FT-IR), transmission electron microscopy (TEM), scanning electron microscopy (SEM), energy dispersive X-ray analysis (EDX) and vibrating sample magnetometry (VSM).

A highly efficient protocol for regioselective ring-opening of epoxides with alcohols, water, acetic acid, and acetic anhydride catalyzed by SbF3

SbF3as an efficient catalyst has been used for regioselective alcoholysis, acetolysis and hydrolysis of epoxides to the corresponding β-alkoxy, β-acetoxy alcohols, and 1,2-diols in high to excellent yields. This study also represents a convenient synthesis of vic-diacetates from ring-opening of epoxides with acetic anhydride.