5330-70-1

Usage

Uses

Used in Carbohydrate Analysis:
Pyruvate phenylhydrazone is used as a diagnostic reagent for the determination of aldoses and ketoses. Its reaction with reducing sugars to form a yellow precipitate aids in the identification and quantification of these sugars, making it an essential component in carbohydrate analysis.
Used in Chemical Research:
Pyruvate phenylhydrazone is utilized in the preparation of various derivatives and as a reagent in organic synthesis. Its unique reactivity with reducing sugars and its solubility properties contribute to its value in advancing chemical research and the development of new compounds and methodologies.
Used in Educational Laboratories:
In educational settings, Pyruvate phenylhydrazone serves as a practical tool for teaching students about the chemical properties of carbohydrates and the techniques used in their analysis. It provides a hands-on approach to understanding the reactions and identification processes involved in carbohydrate chemistry.
Overall, Pyruvate phenylhydrazone is a versatile compound with applications spanning across various scientific disciplines, particularly in the analysis and study of carbohydrates, as well as in the broader realm of chemical research and education.

InChI:InChI=1/C9H10N2O2/c1-7(9(12)13)10-11-8-5-3-2-4-6-8/h2-6,11H,1H3,(H,12,13)/b10-7+

Upstream product

• 64-19-7 acetic acid 
• 127-17-3 2-oxo-propionic acid 
• 100-63-0 phenylhydrazine 
• 588-64-7 benzaldehyde phenylhydrazone 
• 103-02-6 acetone phenylhydrazone 
• 60-29-7 diethyl ether 
• 594-48-9 2,2-dibromopropionic acid 
• 19735-89-8 3-methyl-1-phenylpyrazolin-5(4H)-one 
• 7722-84-1 dihydrogen peroxide 
• 609-14-3 2-acetylpropanoic acid ethyl ester 
• 2684-02-8 benzenediazonium 
• 40697-35-6 2-phenylhydrazono-propionitrile 
• 7732-18-5 water 
• 108-24-7 acetic anhydride 

Downstream Products

• 4413-30-3 N,N'-diphenyl-C-methylformazan 
• 302-72-7 rac-Ala-OH 
• 89314-32-9 2-(4-bromo-phenylhydrazono)-propionic acid 
• 935-07-9 acetaldehyde phenylhydrazone 
• 15719-64-9 methylammonium carbonate 
• 2861-48-5 butane-2,3-dione-bis-phenylhydrazone 
• 22863-24-7 5-methyl-2-phenyl-2,4-dihydro-[1,2,4]triazol-3-one 
• 4413-26-7 1-phenylazo-acetaldehyde-oxime 
• 86100-27-8 2-(phenylhydrazino)propionic acid 
• 62-53-3 aniline 
• 4792-54-5 ethyl pyruvate phenylhydrazone 
• 1015911-62-2 4-FORMYL-1-PHENYL-1H-PYRAZOLE-3-CARBOXYLIC ACID 
• 38562-56-0 3-Methyl-N-(4-nitro-phenyl)-N'''-phenyl-formazan 
• 71466-92-7 methyl 2-(phenylhydrazono)propionate 

Relevant academic research and scientific papers

A novel potent metal-binding NDM-1 inhibitor was identified by fragment virtual, SPR and NMR screening

NDM-1 can hydrolyze nearly all available β-lactam antibiotics, including carbapenems. NDM-1 producing bacterial strains are worldwide threats. It is still very challenging to find a potent NDM-1 inhibitor for clinical use. In our study, we used a metal-binding pharmacophore (MBP) enriched virtual fragment library to screen NDM-1 hits. SPR screening helped to verify the MBP virtual hits and identified a new NDM-1 binder and weak inhibitor A1. A solution NMR study of 15N-labeled NDM-1 showed that A1 disturbed all three residues coordinating the second zinc ion (Zn2) in the active pocket of NDM-1. The perturbation only happened in the presence of zinc ion, indicating that A1 bound to Zn2. Based on the scaffold of A1, we designed and synthesized a series of NDM-1 inhibitors. Several compounds showed synergistic antibacterial activity with meropenem against NDM-1 producing K. pneumoniae.

Sulfamic acid as a green, reusable catalyst for stepwise, tandem & one-pot solvent-free synthesis of pyrazole derivatives

Sulfamic acid (SA) is a bi-functional, cost-effective and reusable green catalyst for the synthesis of 4-(pyrazol-4-yl)methylenepyrazol-5(4H)-one derivatives by one-pot, three-component condensation of pyrazol-4-carbaxaldehydes, β-ketoesters and phenyl hydrazine (Route-I). In addition to this method, another simple condensation of pyrazol-4-carbaxaldehydes with pyrazolone in the presence of SA under the solvent-free condition in good yield is reported. The merits of these protocols are mild conditions, non-aqueous workup, high yields, easy availability of the catalyst, no chromatographic separation and inexpensive solid acid catalyst. Furthermore, SA could be recycled and reused for five times without losing its catalytic activity.

Quantification and mass isotopomer profiling of α-keto acids in central carbon metabolism

Mass spectrometry has been established as a powerful and versatile technique for studying cellular metabolism. Applications range from profiling of metabolites to accurate quantification and tracing of stable isotopes through the biochemical reaction netw

Organotin(IV) complexes with pyruvic acid phenylhydrazone (HPAPD): Synthesis, spectral characterization, and invitro antibacterial activity

The reaction of pyruvic acid phenylhydrazone [HPAPD, (1)] with organotin(IV) chloride(s) leads to the formation of five new organotin(IV) complexes: [MeSnCl2(PAPD)] (2), [BuSnCl2(PAPD)] (3), [PhSnCl2(PAPD)] (4), [Me2

Polyfunctional pyrazoles 5*. preparative synthesis of 1-aryl-4-formylpyrazole- 3-carboxylic acids

Treatment of methyl pyruvate N-arylhydrazones with the Vilsmeier-Haack reagent gave methyl 1-aryl-4-formylpyrazole-3-carboxylates, basic hydrolysis of which yielded the corresponding acids.

α-(1-PHENYLHYDRAZINO)-ALKANONE PHENYLHYDRAZONES: THE REACTION WITH CARBONYL COMPOUNDS

The unsymmetrically disubstituted hydrazines 1 were condensed with carbonyl compounds.Some of the expected condensation products were isolated, but some were formed as unstable intermediates which underwent 1,4-elimination: The phenylhydrazone of the carbonyl compound used was obtained, together with the corresponding phenylazo-alkene 11 or alternatively, the 1,4-addition product of a different protic nucleophile to 11.

A CONVENIENT SYNTHESIS OF 1-ARYL-Δ2-1,2,4-TRIAZOLIN-5-ONES FROM ARYLHYDRAZINES

1-Aryl-1,2,4-triazolin-5-ones are prepared from arylhydrazones of α-keto acids by treatment with diphenylphosphoryl azide.