22863-24-7

Usage

Uses

Used in Pharmaceutical Industry:
2,4-Dihydro-5-methyl-2-phenyl-3H-1,2,4-triazol-3-one is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its role in this industry is crucial for the development of new drugs to address a range of diseases, leveraging its structural properties to enhance medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 2,4-Dihydro-5-methyl-2-phenyl-3H-1,2,4-triazol-3-one is utilized as a precursor in the formulation of pesticides or herbicides. Its chemical composition makes it a candidate for creating effective agents that can protect crops from pests and enhance agricultural productivity.
As the exact properties and potential uses of 2,4-Dihydro-5-methyl-2-phenyl-3H-1,2,4-triazol-3-one are still under investigation, future applications may extend beyond the current scope, particularly as new research uncovers additional capabilities and interactions with biological systems.

Upstream product

• 2597-54-8 ethyl acetylcarbamate 
• 100-63-0 phenylhydrazine 
• 5330-70-1 pyruvic acid phenylhydrazone 
• 1445-45-0 Trimethyl orthoacetate 
• 31084-70-5 N-(1-Ethoxyethyliden)carbamidsaeure-ethylester 
• 917-61-3 sodium isocyanate 
• 75-07-0 acetaldehyde 
• 62-53-3 aniline 
• 28740-63-8 5-methyl-3-phenyl-1,3,4-oxadiazol-2(3H)-one 
• 7647-01-0 hydrogenchloride 
• 7732-18-5 water 
• 127-09-3 sodium acetate 
• 133902-70-2 4-acetyl-1-phenyl-3,3-dimethyl-1,2,4-triazolidin-5-one 
• 59-88-1 phenylhydrazine hydrochloride 

Downstream Products

• 111992-18-8 2-(5-amino-2,4-dichlorophenyl)-4-(difluoromethyl)-2,4-dihydro-5-methyl-3H-1,2,4-triazol-3-one 
• 122836-35-5 sulfentrazone 
• 111992-16-6 4,5-dihydro-3-methyl-4-difluoromethyl-1-(2,4-dichlorophenyl)-1,2,4-triazol-5(1H)-one 
• 111992-17-7 4,5-dihydro-3-methyl-4-difluoromethyl-1-(2,4-dichloro-5-nitrophenyl)-1,2,4-triazole-5(1H)-one 
• 28740-67-2 4-Acetyl-3-methyl-1-phenyl-Δ²-1,2,4-triazolin-5-on 
• 133840-72-9 4,5-dihydro-3-methyl-1-(4-chlorophenyl)-1,2,4-triazol-5(1H)-one 
• 948351-04-0 4-(4-bromo-3-methyl-benzyl)-5-methyl-2-phenyl-2,4-dihydro-[1,2,4]triazol-3-one 
• 22863-25-8 5-methyl-2-(4-nitro-phenyl)-1,2-dihydro-[1,2,4]triazol-3-one 
• 34243-08-8 5-oxo-1-phenyl-2,5-dihydro-1H-[1,2,4]triazole-3-carboxylic acid 
• 90537-59-0 5-chloro-3-methyl-1-phenyl-1H-[1,2,4]triazole 
• 43057-60-9 3-methyl-1-phenyl-1H-1,2,4-triazole 
• 43057-55-2 5-methyl-2-phenyl-1,2-dihydro-[1,2,4]triazole-3-thione 

Relevant academic research and scientific papers

Preparation method of 1-(2,4-dichlorophenyl)-4-difluoromethyl-3-methyl-1H-1,2,4-triazole-5-one

The invention provides a preparation method of 1-(2,4-dichlorophenyl)-4-difluoromethyl-3-methyl-1H-1,2,4-triazole-5-one. The method comprises the steps: taking aniline as a raw material; reducing witha catalyst X to prepare phenylhydrazine; under the action of acetaldehyde and sodium cyanate, carrying out cyclization on phenylhydrazine to generate 1-phenyl-3-methyl-1H-1,2,4-triazole-5-one; carrying out a reaction on 1-phenyl-3-methyl-1H-1,2,4-triazole-5-one and monochlorodifluoromethane under the action of a catalyst Y to generate 1-phenyl-3-methyl-4-difluoromethyl-1H-1,2,4-triazole-5-one, and carrying out catalytic chlorination through a catalyst Z to prepare 1-(2,4-dichlorophenyl)-4-difluoromethyl-3-methyl-1H-1,2,4-triazole-5-one.

A aryltriazolinones preparation method

The invention discloses a method for preparing aryl triazolinone. The method comprises the following steps: by taking aryl triazolinone as a raw material, taking an oxygen-containing gas or hydrogen peroxide water solution as an oxidant, and taking active carbon as a catalyst, performing oxidation reaction to obtain aryl triazolinone. By adopting the method, a new concept for the synthesis of the aryl triazolinone compound is provided, the hydrogen peroxide solution or the oxygen-containing gas is taken as the oxidant, the active carbon is taken as the catalyst, and the traditional processing modes of hypohalous acid and salt thereof, halogen oxidant or metal compound catalyst are substituted; the halogen and the metal compound are not contained in the wastewater, so that the environment is not polluted; when the optimized active carbon is adopted, the purity and the yield of the product are high. The environment pollution caused by the halogen-containing oxidant and the metal compound is avoided, the production process is clean, the reaction process is environmentally friendly, the product content and the yield are high and the economic and environmental protection benefits are obvious, so that the method is a scientific and environment-friendly novel method for producing the aryl triazolinone compound.

C5-Alkyl-1,3,4-Oxadiazol-2-ones Undergo Dealkylation upon Nitrogen Insertion to Form 2H-1,2,4-Triazol-3-ones: Synthesis of 1,2,4-Triazol-3-one Hybrids with Triazolothiadiazoles and Triazolothiadiazines

The present study emphasizes on the dealklylation of 3-aryl-5-alkyl-2-oxo-Δ4-1,3,4-oxadiazoles when reacted with formamide resulting in the formation of 2-aryl-2H-1,2,4-triazol-3(4H)-ones as major product. Subsequent reactions of 2-aryl-2H-1,2,

NOVEL DUAL ACTION RECEPTORS ANTAGONISTS (DARA) AT THE AT1 AND ETA RECEPTORS

The present invention relates to new compounds of the formula [Chemical formula should be inserted here. Please see paper copy] wherein R1, R2, R3, and R31 are as specified herein. The invention also relates to a method for preparation thereof, as well as combinations of the new compounds with previously known agents. The invention also relates to the use of the above-mentioned compounds and combinations for the preparation of a medicament for treating hypertension of different kinds, alleviating organ damage of different kinds, treating or preventing diabetic nephropathy, treating endothelin and angiotensin mediated disorders, and treating prostate cancer.

Method of preparing aryl triazolinones with trialkyl orthoacetates

A method for preparing an alkoxyethylidene-substituted aryl hydrazine having the formula STR1 and thereafter cyclizing the same with a cyanate salt under mildly acidic conditions in the presence of an organic solvent, optionally in the presence of a cycli

Triazolinone ring formation in tert-butanol

A process for the production of aryl triazolinones of the formula STR1 wherein R is lower alkyl; X is independently halogen, lower alkyl, nitro, hydroxy, NHSO2 R', --N(SO2 R')2, --N(R'(SO2 R' where R' is lower alkyl, and n is an integer from 0 to 3; which comprises treating, in a tert-butanol medium, an aryl hydrazine of the formula STR2 sequentially with (i) a C1 -C3 aldehyde, (ii) a cyanate and weak organic acid, and (iii) a hypochlorite, a salt thereof, or a halogen.

A Convenient Synthesis of 1-Aryl-3-methyl-1,2,4-triazolin-5-ones From the Reaction Between Acetone Arylhydrazones and Acetyl Isocyanate

The reaction of acetone arylhydrazones with acetyl isocyanate gave the corresponding 4-acetyl-1-aryl-3,3-dimethyl-1,2,4-triazolidin-5-ones which eliminated acetone upon hydrolysis to give 1-aryl-3-methyl-1,2,4-triazolin-5-ones.The above transformation can be achieved in one pot by a simple solvent swap.

A CONVENIENT SYNTHESIS OF 1-ARYL-Δ2-1,2,4-TRIAZOLIN-5-ONES FROM ARYLHYDRAZINES

1-Aryl-1,2,4-triazolin-5-ones are prepared from arylhydrazones of α-keto acids by treatment with diphenylphosphoryl azide.