53316-60-2

Upstream product

• 39143-07-2 4-anisylidene-3-methyl-1-phenylpyrazol-5-one 
• 109-77-3 malononitrile 
• 123-11-5 4-methoxy-benzaldehyde 
• 89-25-8 edaravone 
• 2826-26-8 2-(4-methoxyphenylmethylene)malononitrile 
• 106763-17-1 4-methoxybenzylidenecyanothioacetamide 
• 71289-18-4 [(4-methoxy-phenyl)-(3-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-4-yl)-methyl]-malononitrile 
• 141-97-9 ethyl acetoacetate 
• 100-63-0 phenylhydrazine 
• 19735-89-8 3-methyl-1-phenylpyrazolin-5(4H)-one 

Downstream Products

• 1334596-80-3 5-amino-4-(4-methoxyphenyl)-3-methyl-1-phenyl-4,8-dihydro-2(H)-pyrazolo[4',3':5,6]pyrano[2,3-d]pyrimidine-7(1H)-thione 
• 1334596-70-1 5-amino-4-(4-methoxyphenyl)-3-methyl-1-phenyl-4,8-dihydro-2(H)-pyrazolo[4',3':5,6]pyrano[2,3-d]pyrimidine-7(1H)-one 
• 1375261-78-1 4-(4-methoxyphenyl)-3-methyl-1-phenyl-4,6-dihydropyrazolo[4',3':5,6]pyrano[2,3-d]pyrimidine-5(1H)-one 
• 71289-13-9 4-(4-methoxyphenyl)-3,7-dimethyl-1-phenyl-4,6-dihydropyrazolo[4',3':5,6]pyrano[2,3-d]pyrimidine-5(1H)-one 
• 1444154-64-6 N-[4-(4-methoxyphenyl)-3-methyl-1-phenyl-7-thioxo-1,4,7,8-tetrahydropyrazolo[4’,3’:5,6]pyrano[2,3-d]pyrimidine-5-yl]thiourea 
• 1444154-54-4 4-(4-methoxyphenyl)-5-imino-3-methyl-1,6-diphenyl-4,5,6,8-tetrahydropyrazolo[4’,3’:5,6]pyrano[2,3-d]pyrimidine-7(1H)-thione 
• 1444154-45-3 3-methyl-4-(4-methoxyphenyl)-1-phenyl-4,8-dihydropyrazolo[4’,3’:5,6]-pyrano[2,3-d]pyrimidine-5,7(1H,6H)-dithione 

Relevant academic research and scientific papers

Supported palladium oxide nanoparticles in Al-SBA-15 as an efficient and reusable catalyst for the synthesis of pyranopyrazole and benzylpyrazolyl coumarin derivatives via multicomponent reactions

An eco-friendly method for diversity-oriented synthesis of substituted dihydropyrano[2,3-c]pyrazole and benzylpyrazolyl coumarin derivatives has been achieved via one-pot and multicomponent reaction in the presence of PdO/Al-SBA-15 as an efficient and rec

Catalyst-free UV365-assisted synthesis of pyran annulated heterocyclic scaffolds and evaluation of their antibacterial activities

A convenient and eco-friendly, one-pot synthetic protocol for pharmaceutically important pyran-based heterocyclic compounds is repeated herein. The reactions were carried out at room temperature in a water–ethanol solvent mixture under direct irradiation

Tungstic acid (H4WO5) immobilized on magnetic-based zirconium amino acid metal–organic framework: An efficient heterogeneous Br?nsted acid catalyst for l-(4-phenyl)-2,4-dihydropyrano[2,3c]pyrazole derivatives preparation

A new magnetic nanocatalyst based on the immobilization of tungstic acid onto new design robust, cost-effective, green, and scalable zirconium-L-aspartate amino acid metal–organic framework (MOF)-grafted L-(+)-tartaric acid stabilized magnetite nanopartic

Sugarcane Bagasse Ash-Based Silica-Supported Boric Acid (SBA-SiO2-H3BO3): A Versatile and Reusable Catalyst for the Synthesis of 1,4Dihydropyrano[2,3c]pyrazole Derivatives

Abstract: A simple, green, and efficient protocol has been developed for the synthesis of biologically active 1,4dihydropyrano[2,3c]pyrazole derivatives via one-pot four-component reaction of various substituted benzaldehydes, hydrazine hydrate or phenylh

Sulfonic acid-functionalized Fe3O4-supported magnetized graphene oxide quantum dots: A novel organic-inorganic nanocomposite as an efficient and recyclable nanocatalyst for the synthesis of dihydropyrano[2,3-c]pyrazole and 4H-chromen

In this research, the main emphasis has been focused on the preparation of a novel Fe3O4-supported propane-1-sulfonic acid-grafted graphene oxide quantum dots (Fe3O4@GOQD-O-(propane-1-sulfonic acid)) that it was

Synthesis, characterization and application of Fe3O4@SiO2@CPTMO@DEA-SO3H nanoparticles supported on bentonite nanoclay as a magnetic catalyst for the synthesis of 1,4-dihydropyrano[2,3-c]pyrazoles

Fe3O4 nanoparticles were prepared and decorated on the surface of nanobentonite (NB), and subsequently modified by the organic and inorganic linkers and then sulfonic acid immobilization on the nanoparticles. The NB-Fe3Os

Ligand based design and synthesis of pyrazole based derivatives as selective COX-2 inhibitors

The design and synthesis of novel pyrazole based derivatives has been carried out using the ligand based approach like pharmacophore and QSAR modelling of reported pyrazoles from the available literature to investigate the chemical features that are essential for the design of selective and potent COX-2 inhibitors. Both pharmacophore and QSAR models with good statistical parameters were selected for the design of the lead molecule. Also by exploiting the chemical structures of selective and marketed COX-2 inhibitors, celecoxib and SC-558 were used in designing the molecules which are used in the treatment of inflammation and related disorders. The therapeutic action of the Non-Steroidal Anti-inflammatory Agents (NSAIDs) is based primarily on the COX-2 inhibition. With this background we have synthesized some azomethine derivatives of 3-methyl-1-substituted-4-phenyl-6-[{(1E)-phenylmethylene}amino]-1,4-dihydro pyrano[2,3-c]pyrazole-5-carbonitrile 6(a-o) and were characterized by 1HNMR, 13CNMR and Mass spectral techniques. All the synthesized pyrazole derivatives were tested for in vitro membrane stability property in both COX-1 & COX-2 inhibition studies and in vivo anti-inflammatory activity by carrageenan induced rat paw edema model. Among them, compound 6k showed very good activity by in vivo anti-inflammatory activity with 0.8575 mmol/kg as ED50. Similarly compounds 6m, 6o, 6i and 6h exhibited comparable anti-inflammatory activity to standard drugs. Also the active compounds were further screened for ulcerogenic activity and were found be safer with less ulcer index compared to the marketed drugs like aspirin, ibuprofen and celecoxib.

Fe3O4-supported N-pyridin-4-amine-grafted graphene oxide as efficient and magnetically separable novel nanocatalyst for green synthesis of 4H-chromenes and dihydropyrano[2,3-c]pyrazole derivatives in water

Abstract: Fe3O4-magnetized N-pyridin-4-amine-functionalized graphene oxide [Fe3O4@GO-N-(pyridin-4-amine)] was readily prepared via a three-step procedure. The synthesized nanofilms were characterized by scanning

Preparation, characterization and catalytic application of molybdenum Schiff-base complex immobilized on silica-coated Fe3O4 as a reusable catalyst for the synthesis of pyranopyrazole derivatives

A recoverable molybdenum Schiff-base complex immobilized on silica-coated Fe3O4 nanoparticles was prepared and characterized. This superparamagntic nanocatalyst, which is separable using an external magnet, can be used as an efficien

A concise route for the one-pot multi-component synthesis of 4,6-disubstituted 2-aminopyridine-3-carbonitriles and pyranopyrazoles using cobalt (II) nitrate hexahydrate as catalyst

Three facile and efficient routes for one-pot, cobalt (II) nitrate hexahydrate catalyzed multi-component synthesis of 2-amino-3-cyanopyridine and pyranopyrazole derivatives have been developed. The present protocols offer the products in good yields from the simple and readily available starting materials. The other salient features of these protocols are operational simplicity, easy isolation of product without the need of column chromatographic purification, and the use of cobalt (II) nitrate hexahydrate as an efficient catalyst.