5339-69-5

Usage

Uses

N-Isopropylbenzenesulfonamide can be used to treat hypertension.

InChI:InChI=1/C9H13NO2S/c1-8(2)10-13(11,12)9-6-4-3-5-7-9/h3-8,10H,1-2H3

Upstream product

• 75-31-0 isopropylamine 
• 98-09-9 benzenesulfonyl chloride 
• 349098-30-2 C₁₆H₁₉NO₂S 
• 98-10-2 benzenesulfonamide 
• 67-63-0 isopropyl alcohol 
• 108-20-3 di-isopropyl ether 
• 75-26-3 isopropyl bromide 

Downstream Products

• 59263-13-7 N-isopropyl-N-nitro-benzenesulfonamide 
• 66896-78-4 N-(2-Chloro-benzoyl)-N-isopropyl-benzenesulfonamide 
• 33489-84-8 N-Isopropyl-N-(3-nitro-phenylsulfanyl)-benzenesulfonamide 
• 24265-46-1 N-Isopropyl-N-(4-methoxy-phenylsulfanyl)-benzenesulfonamide 
• 33489-83-7 N-(3-Chloro-phenylsulfanyl)-N-isopropyl-benzenesulfonamide 
• 24265-52-9 N-(2,4-Dinitro-phenylsulfanyl)-N-isopropyl-benzenesulfonamide 
• 24265-48-3 N-Isopropyl-N-phenylsulfanyl-benzenesulfonamide 
• 24265-49-4 N-(4-Chloro-phenylsulfanyl)-N-isopropyl-benzenesulfonamide 
• 98-10-2 benzenesulfonamide 

Relevant academic research and scientific papers

Structurally Diverse Synthesis of Five-, Six-, and Seven-Membered Benzosultams through Electrochemical Cyclization

We have developed a metal- and oxidant-free approach to structurally diverse synthesis of benzosultams from aryl sulfonamides through an electrochemical cyclization. Upon variation of the ortho substituent on aryl sulfonamides, five-, six-, and seven-memb

Intramolecular NC rearrangements involving sulfonamide protecting groups

The reaction of amine derivatives orthogonally protected with an aryl sulfonamide and a carbamate, via a base-mediated nitrogen to carbon rearrangement is reported. This noteworthy isomerisation has implications for the use of sulfonamide protecting group

Synthesis of nitromethyl-substituted oxindole derivatives via a desulfonylation cascade

A cascade reaction giving nitromethyl-substituted oxindole derivatives was developed. The reaction used NaNO2 as the nitro source and potassium peroxydisulfate as an oxidant. This reaction proceeded via a radical mechanism involving substitution-desulfonlylation-cyclization steps in one pot and afforded good yields under mild conditions without using toxic metal catalysts. The resultant nitromethyl-substituted oxindole derivatives are convenient and valuable structures for different derivative syntheses.

N-alkylation of sulfonamides with alcohols by Tf2O

N-sulfonylpyrrolidines and N-alkyl sulfonamides were efficiently prepared via alkylation of sulfonamides with 1,4- diols or alcohols by Tf2O. The reaction occurred under mild reaction conditions in moderate to high yields and tolerated aryl and aliphatic sulfonamides.

Oxidative debenzylation of N-benzyl amides and O-benzyl ethers using alkali metal bromide

The oxidative debenzylation of N-benzyl amides and O-benzyl ethers was promoted with high efficiency by a bromo radical formed through the oxidation of bromide from alkali metal bromide under mild conditions. This reaction provided the corresponding amides from N-benzyl amides and carbonyl compounds from O-benzyl ethers in high yields.

Br?nsted acid-assisted N-alkylation of sulfonamides using ethers as the alkylation reagents

N-Alkylation of sulfonamides using cyclic ethers as alkylation reagents and Br?nsted acid as a catalyst produced pyrrolidine and piperidine derivatives in good yields. When using symmetrical and unsymmetrical ethers as alkylation reagents, mono-N-alkylation of sulfonamides took place to afford the corresponding products.