54167-76-9

Usage

Uses

Used in Pharmaceutical Applications:
N-(2-phenyl-imidazo[1,2-a]pyridin-3-yl)-acetamide is used as a building block in the synthesis of various biologically active molecules due to its structural properties. Its specific molecular structure allows for interactions with specific targets in biological systems, making it a potentially useful compound in drug development.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, N-(2-phenyl-imidazo[1,2-a]pyridin-3-yl)-acetamide is used as a starting point for the development of new therapeutic agents. Its properties as an imidazo[1,2-a]pyridine derivative make it of interest for further research and potential applications in creating novel drugs with improved efficacy and selectivity.

Upstream product

• 67292-98-2 3-nitro-2-phenylimidazo<1,2-a>pyridine 
• 67625-22-3 2-bromo-3-nitro-imidazo[1,2-a]pyridine 
• 98-80-6 phenylboronic acid 
• 112581-95-0 2-Bromoimidazo[1,2-a]pyridine 
• 504-29-0 2-aminopyridine 
• 3999-05-1 2-chloroimidazo[1,2-a]pyridine 
• 126202-06-0 2-(2-imino-1,2-dihydropyridin-1-yl)acetic acid 
• 100-52-7 benzaldehyde 
• 75-36-5 acetyl chloride 
• 3999-29-9 2-phenylimidazo[1,2-a]pyridin-3-amine 
• 108-24-7 acetic anhydride 

Relevant academic research and scientific papers

Exploration of versatile reactions on 2-chloro-3-nitroimidazo[1,2-a] pyridine: Expanding structural diversity of C2- and C3-functionalized imidazo[1,2-a]pyridines

Alternative strategies for functionalizing 2-chloro-3-nitroimidazo[1,2-a] pyridine have been developed. Suzuki-Miyaura cross-coupling reaction provided easily the corresponding 2-arylated compounds, and herefrom the nitro group was reduced into amine which afforded amides, anilines, and ureas in the 3-position. The amination of the key compound using a metal-catalyzed reaction was reported. This study highlighted the importance of the nitro group to facilitate the chlorine displacement. Other nucleophilic aromatic substitutions open a route to various products derived from imidazo[1,2-a]pyridine.

Imidazo[l,2-b]pyridazines. XXIII Some 5-Deaza Analogues. Syntheses of Some 2- Aryl-6-(chloro, methoxy or unsubstituted)-3-(variously substituted)imidazo[l,2-a]pyridines and Their Affinity for Central and Mitochondrial Benzodiazepine Receptors

The syntheses of ethyl {2′-aryl-6′-(chloro, methoxy and unsubstituted)imidazo[l,2-a]pyridin-3′-yl}-2-(acylamino, acetoxy and hydroxy)acetates, 3-benzamidomethyl-2-benzoyl-6-(chloro and methoxy)imidazo[l,2-a]pyridines, 3-amino-6-chloro-2-phenylimidazo[l,2-a]pyridine and ethyl 2-(2′-phenylimidazo[l,2-a]pyridin-3′-yl)acetate are reported. The ability of these compounds to displace [3H]diazepam from central and mitochondrial (peripheral-type) benzodiazepine receptors has been examined. Ethyl 2-benzamido-2-{6′-chloro-2′-(4″-chlorophenyl)imidazo[l,2-a] pyridin-3′-yl}acetate (21) was selective for peripheral-type receptors (IC50 13 nM) but none bound strongly to central receptors.

EFFECTIVE STRATEGY FOR THE SYNTHESIS OF PYRIDOIMIDAZOISOQUINOLINE SYSTEM

Annulation of 3-aceta(benza)mido-2-phenylimidazopyridines (2a,b) by phosphorus oxychloride results in the formation of pyridoimidazoisoquinolines (3a,b) as potent antileukemic structures.An alternative route for obtaining the isoquinoline framework was centered on the aza-Wittig reaction of iminophosphorane (4) with different isocyanates.