54245-41-9

Upstream product

• 100-47-0 benzonitrile 
• 583-53-9 2,3-dibromobenzene 
• 583-55-1 1-Bromo-2-iodobenzene 
• 214360-48-2 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile 
• 138642-62-3 2-Cyanophenylboronic acid 
• 172732-52-4 o-cyanophenylboronic acid-1,3-propylene glycol ester 
• 13029-09-9 2,2'-dibromobiphenyl 
• 544-92-3 copper(I) cyanide 

Downstream Products

• 4269-17-4 4-bromo-9H-fluorene-9-one 
• 69200-16-4 2'-bromo-[1,1'-biphenyl]-2-carboxylic acid 
• 16573-51-6 6-benzyl-phenanthridine 
• 16573-53-8 6‐cyclohexylphenanthridine 
• 2720-93-6 6-phenylphenanthridine 
• 98351-80-5 6-(4′-chlorophenyl)phenanthridine 
• 98351-86-1 6-(4-methoxyphenyl)phenanthridine 
• 452070-80-3 6-(4-aminophenyl)phenanthridine 
• 32317-26-3 7-methyl-6-phenylphenanthridine 
• 32317-27-4 6-mesitylphenanthridine 
• 229-87-8 phenanthridine 
• 1015-89-0 6(5H)-phenanthridinone 

Relevant academic research and scientific papers

Production method for 4-bromo fluorenone

The invention discloses a production method for 4-bromo fluorenone, belonging to the field of organic chemical synthesis. The production method is realized by comprising the following steps: reacting cyanobenzene as a raw material with o-dibromobenzene under the protection of argon gas and the actions of a palladium catalyst, a copper catalyst and an organic phosphine ligand so as to obtain 2-bromo-2'-carbonitrile biphenyl, and carrying out hydrolyzation and closed-loop synthesizing so as to obtain the 4-bromo fluorenone. The production method for the 4-bromo fluorenone is simple to operate in reaction process, has low production cost and is suitable for industrial production. The 4-bromo fluorenone can be applied in the fields of organic optoelectronic materials, medicines, pesticides, etc.

Hydride-induced anionic cyclization: An efficient method for the synthesis of 6- H -phenanthridines via a transition-metal-free process

A novel procedure for hydride-induced anionic cyclization has been developed. It includes the reduction of a biaryl bromo-nitrile with a nucleophilic aromatic substitution (SNAr). A range of polysubstituted 6-H-phenanthridines were so obtained in moderate to good yield with good substrate tolerance. This method involves a concise transition-metal-free process and was applied to synthesize natural alkaloids.

Synthesis of polysubstituted phenanthridines via ligand-free copper-catalyzed annulation

A novel procedure for the cascade reaction of the addition of a Grignard reagent to a nitrile with a copper-catalyzed C-N bond coupling was developed, which afforded various polysubstituted phenanthridines in moderate to good yields with tolerance for a wide variety of substrates. Experimental data demonstrated that the reaction proceeded more likely through a Cu(I/III) catalytic cycle.

Novel syntheses of fluorenones via nitrile-directed palladium-catalyzed C-H and dual C-H bond activation

Novel procedures for the [Pd]/[Ag]/TFA system catalyzed cascade reactions of nitrile directed remote C-H and dual C-H bond activation with insertion of nitrile were developed, which afforded variously polysubstituted fluorenones in moderate to good yields with tolerance of a wide variety of substrates.