5449-21-8

Basic information

• Product Name: biphenyl-4-yl(oxo)acetic acid
• CAS NO: 5449-21-8
• Molecular Formula: C₁₄H₁₀O₃
• Molecular Weight: 226.2274
• Mol File: 5449-21-8.mol
• Article Data: 22

Chemical Properties

• Boiling Point: 397.8°C at 760 mmHg
• Flash Point: 208.5°C
• Density: 1.25g/cm³
• Vapor Pressure: 4.85E-07mmHg at 25°C
• Refractive Index: 1.606
• CAS DataBase Reference: biphenyl-4-yl(oxo)acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: biphenyl-4-yl(oxo)acetic acid(5449-21-8)
• EPA Substance Registry System: biphenyl-4-yl(oxo)acetic acid(5449-21-8)

Safety Data

• Hazardous Substances Data: 5449-21-8(Hazardous Substances Data)

Usage

General Description

Biphenyl-4-yl(oxo)acetic acid is a chemical compound with the molecular formula C14H10O3. It belongs to the class of aromatic carboxylic acids and consists of a biphenyl group attached to an acetic acid moiety. biphenyl-4-yl(oxo)acetic acid is commonly used as a building block in the synthesis of various pharmaceuticals and agrochemicals. It exhibits anti-inflammatory and analgesic properties, making it a potential candidate for the development of new drugs. Biphenyl-4-yl(oxo)acetic acid is also used as a precursor in the production of dyes and pigments, as well as in the synthesis of various organic compounds for industrial applications.

Upstream product

• 1033590-36-1 1-([1,1'-biphenyl]-4-yl)-2-morpholino-2-thioxoethanone 
• 2350-89-2 p-vinylbiphenyl 
• 124-38-9 carbon dioxide 
• 3218-36-8 4-Phenylbenzaldehyde 
• 106991-85-9 1-(1,1'-biphenyl-4-yl)-2-[2-(1,1'-biphenyl-4-yl)-2-oxoethylsulfanyl]ethanone 
• 92-66-0 4-bromo-1,1'-biphenyl 
• 92-91-1 biphenyl-4-acetaldehyde 
• 99114-44-0 1-Biphenyl-4-yl-2-methanesulfinyl-2-methylsulfanyl-ethylideneamine 
• 2920-38-9 4-cyano-1,1'-biphenyl 
• 99114-41-7 S-methyl 2-([1,1'-biphenyl]-4-yl)-2-oxoethanethioate 
• 6244-53-7 ethyl (4-phenylphenyl)glyoxylate 
• 92-52-4 biphenyl 

Downstream Products

• 1415473-88-9 N-(2-([1,1'-biphenyl]-4-carbonyl)phenyl)acetamide 
• 1613439-81-8 N-(3-(N,N-dimethylaminocarbonylphenyl))-2-oxo-2-(4-phenylphenyl)acetamide 
• 16738-11-7 methyl 2-([1,1'-biphenyl]-4-yl)-2-oxoacetate 
• 15082-28-7 2-(4-tert-butylphenyl)-5-(4-biphenylyl)-1,3,4-oxadiazole 
• 221101-61-7 2-([1,1’-biphenyl]-4-yl)glycine 
• 887267-97-2 2-([1,1'-biphenyl]-4-yl)-5-(trifluoromethyl)-1,3,4-oxadiazole 
• 858100-01-3 5-(biphenyl-4-yl)-1,3,4-oxadiazole-2-carboxylic acid ethyl ester 
• 1325214-49-0 2,3,5-triphenyl-1H-inden-1-one 
• 500881-71-0 1-([1,1’-biphenyl]-4-yl)-3-phenylprop-2-yn-1-one 

Relevant articles and documents

Diazotrifluoroethyl Radical: A CF3-Containing Building Block in [3 + 2] Cycloaddition

We present herein a visible-light-induced [3 + 2] cycloaddition of a hypervalent iodine(III) reagent with α-ketoacids for the construction of 5-CF3-1,3,4-oxadiazoles that are of importance in medicinal chemistry. The reaction proceeds smoothly without a photocatalyst, metal, or additive under mild conditions. Different from the well-established trifluorodiazoethane (CF3CHN2), the diazotrifluoroethyl radical [CF3C(·)N2], a trifluoroethylcarbyne (CF3C?:) equivalent and an unusual CF3-containing building block, is involved in the present reaction system.

Metal-free C3-H acylation of quinoxalin-2(1: H)-ones with α-oxo-carboxylic acids

Direct C3-H acylation of quinoxalin-2(1H)-ones with α-oxocarboxylic acids under thermo conditions promoted by PIDA has been achieved in a moderate to good yield in a very fast manner. Mechanistic study revealed that the reaction proceeds via a radical pro

Selective photoredox decarboxylation of α-ketoacids to allylic ketones and 1,4-dicarbonyl compounds dependent on cobaloxime catalysis

A photoredox/cobaloxime co-catalyzed coupling reaction of α-ketoacids and methacrylates to obtain allylic ketones is described. Without the cobaloxime catalyst, 1,4-dicarbonyl compounds are generated. The cobaloxime catalyst enables dehydrogenation to generate the formation of new olefins. The generality, good substrate scope and mild conditions are good features in the photoredox/cobaloxime catalysis protocol, and this method will provide new opportunities for the functionalization of more olefins.