5449-71-8

Basic information

• Product Name: methyl 2-(4-methoxybenzoyl)benzoate
• CAS NO: 5449-71-8
• Molecular Formula: C₁₆H₁₄O₄
• Molecular Weight: 270.28
• Mol File: 5449-71-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 396.6°C at 760 mmHg
• Flash Point: 175.3°C
• Density: 1.177g/cm³
• Vapor Pressure: 1.68E-06mmHg at 25°C
• Refractive Index: 1.562
• CAS DataBase Reference: methyl 2-(4-methoxybenzoyl)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-(4-methoxybenzoyl)benzoate(5449-71-8)
• EPA Substance Registry System: methyl 2-(4-methoxybenzoyl)benzoate(5449-71-8)

Safety Data

• Hazardous Substances Data: 5449-71-8(Hazardous Substances Data)

Upstream product

• 610-97-9 o-iodo-methyl-benzoic acid 
• 123-11-5 4-methoxy-benzaldehyde 
• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 1151-15-1 2-(4-methoxybenzoyl)benzoic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 74-88-4 methyl iodide 
• 85-44-9 phthalic anhydride 
• 17763-70-1 methyl 2-(trifluoromethylsulfonyloxy)benzoate 
• 70744-47-7 (p-methoxyphenyl)tri-n-butylstannane 
• 4376-18-5 Monomethyl phthalate 
• 201230-82-2 carbon monoxide 
• 85-57-4 2-(4-hydroxy-benzoyl)-benzoic acid 
• 77-78-1 dimethyl sulfate 
• 610-94-6 2-bromobenzoic acid methyl ester 

Downstream Products

• 21615-74-7 3-(4-methoxyphenyl)phthalide 
• 7477-30-7 1,2-bis-(α-hydroxyimino-4-methoxy-benzyl)-benzene 
• 855422-65-0 1,2-bis-(4-hydroxy-benzoyl)-benzene 
• 5441-28-1 1,4-bis-(4-methoxy-phenyl)-phthalazine 
• 57591-01-2 (2-(hydroxymethyl)phenyl)(4-methoxyphenyl)methanol 
• 1151-15-1 2-(4-methoxybenzoyl)benzoic acid 
• 7477-28-3 o-bis(p-methoxyphenoyl)benzene 

Relevant articles and documents

Construction of an isoquinolinone framework from carboxylic-ester-directed umpolung ring opening of methylenecyclopropanes

An interesting type of reaction involving functionalized methylenecyclopropanes (MCPs) has been revealed. Here, a nucleophilic attack of an anionic species onto a partially polarity-reversed MCP was realized by treating a neighbouring carboxylic ester tethered to the MCP and amine with KHMDS to realize an umpolung ring opening of the MCP. This work established an operationally convenient protocol for the rapid construction of isoquinolinone frameworks. This journal is

Ruthenium-Catalyzed Enantioselective Hydrogenation/Lactonization of 2-Acylarylcarboxylates: Direct Access to Chiral 3-Substituted Phthalides

Highly enantioselective tandem hydrogenation/lactonization of various 2-acylarylcarboxylates including 2-aroylarylcarboxylates were realized by using [RuCl(benzene)(S)-SunPhos]Cl as the catalyst under mild reaction conditions. Excellent enantioselectivities (up to 99.6 % ee) and activities (S/C=1000) were obtained. This convenient and practical method enables a direct access to a series of highly optically pure 3-substituted phthalides that are very important molecules as valuable pharmacological compounds and diversified synthons for medicinal chemistry. Moreover, a gram-scale reaction was performed to further demonstrate the practicality of this approach.

PROCESS FOR PRODUCING 4-PHENYL-4-OXO-2-BUTENOIC ESTER DERIVATIVE

A 4-phenyl-4-oxo-2-butenoate derivative is stably supplied in a short period of time, at low cost, in high purity and on an industrial scale by a process for producing the 4-phenyl-4-oxo-2-butenoate derivative, which comprises simultaneously or continuously reacting a sulfuric ester, an aromatic hydrocarbon and a maleic anhydride derivative.