5453-48-5

Usage

Uses

Used in Chemical Synthesis:
N-(4-Chlorophenyl) acrylamide is used as a reagent in chemical synthesis for the production of various molecules. Its unique structure allows for diverse reactions under certain conditions, making it a valuable component in the synthesis of complex organic compounds.
Used in Academic Research:
In academic research, N-(4-Chlorophenyl) acrylamide is used as a model compound to study the reactivity and properties of acrylamide and chlorophenyl groups. This helps researchers understand the behavior of similar compounds and develop new synthetic strategies and applications.
Used in Industrial Processes:
N-(4-Chlorophenyl) acrylamide is employed in industrial processes as a reagent for the production of specialty chemicals and materials. Its versatility in chemical reactions enables the creation of a wide range of products, from pharmaceuticals to advanced materials.
Used in Pharmaceutical Development:
In the pharmaceutical industry, N-(4-Chlorophenyl) acrylamide is used as a starting material for the synthesis of potential drug candidates. Its structural features can be modified to create new compounds with therapeutic properties, contributing to the development of novel treatments for various diseases.
Used in Material Science:
In material science, N-(4-Chlorophenyl) acrylamide is used as a component in the development of new materials with specific properties. Its reactivity and ability to form diverse molecules make it a valuable resource for creating materials with tailored characteristics for various applications, such as electronics, coatings, and adhesives.

InChI:InChI=1/C9H8ClNO/c1-2-9(12)11-8-5-3-7(10)4-6-8/h2-6H,1H2,(H,11,12)

Upstream product

• 100-00-5 4-chlorobenzonitrile 
• 140-88-5 ethyl acrylate 
• 16619-64-0 1-(2-chlorophenyl)-3-phenyl-2-propyn-1-one 
• 106-47-8 4-chloro-aniline 
• 814-68-6 acryloyl chloride 
• 637-87-6 1-Chloro-4-iodobenzene 
• 79-06-1 2-propenamide 
• 598-72-1 2-Bromopropionic acid 
• 590-92-1 3-Bromopropionic acid 
• 340011-45-2 N-(4-chlorophenyl)-3-(phenylsulfonyl)propanamide 
• 126545-19-5 N-methoxy-N-phenylacrylamide 

Downstream Products

• 108811-82-1 1,4,5,6,7,7-Hexabromo-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid (4-chloro-phenyl)-amide 
• 340011-50-9 N-allyl N-(4-chlorophenyl)acrylamide 
• 35600-92-1 2-Bromo-N-(4-chlorophenyl)-2-propenamide 

Relevant academic research and scientific papers

COMPOSITONS AND METHODS FOR MODULATING UBA5

Disclosed herein, inter alia, are compositions and methods useful for inhibiting ubiquitin-like modifier activating enzyme 5.

COMPOSITIONS AND METHODS FOR MODULATING PPP2R1A

Disclosed herein, inter alia, are compositions and methods useful for modulating PPP2R1 A and for the treatment of cancer.

COMPOSITIONS AND METHODS FOR INHIBITING RETICULON 4

Disclosed herein, inter alia, are compositions and methods useful for inhibiting reticulon 4(RTN4).

Anilines as substrates in consecutive four-component synthesis of novel 1-aryl-5-benzoyl-6-phenyl-3,4-dihydropyridin-2(1 H)-ones

The consecutive four-component synthesis of 5-acylpyridin-2(1H)-ones initiated by a copper-free alkynylation in a one-pot fashion has been expanded to include considerably less nucleophilic anilines as the amine component in the Michael addition step by altering the solvent system to 1,4-dioxane; 17 examples for the synthesis of 1-aryl-5-benzoyl-6-phenyl-3,4-dihydropyridin-2(1H) -ones were obtained in moderate to good yields.

Ligand-free CuTC-catalyzed N-arylation of amides, anilines and 4-aminoantipyrine: Synthesis of N-arylacrylamides, 4-amido-N-phenylbenzamides and 4-amino(N-phenyl)antipyrenes

N-Arylation of amides and anilines with aryl iodides was efficiently catalyzed by copper thiophenecarboxylate under ligand-free conditions with good to excellent yields. A variety of substituted aryl iodides, amides, anilines and 4-aminoantipyrine were found to be applicable to the simple catalytic system. Furthermore, some practical, unique secondary amides, such as N-arylacrylamides and 4-amido-N-phenylbenzamides, and 4-amino(N-phenyl)antipyrenes, which are difficult to obtain by the classical methods, were prepared.

An efficient copper-catalyzed N-arylation of amides: Synthesis of N-arylacrylamides and 4-amido-N-phenylbenzamides

Copper-catalyzed intermolecular C-N bond-forming reactions between aryl iodides and amides are described using sodium ascorbate, which is both cheap and nontoxic, as the additive. A variety of functionalized amides including some practical, unique secondary amides, such as N-arylacrylamides and 4-amido-N-phenylbenzamides, which are difficult to obtain by the classical methods, are prepared. Furthermore, some tertiary amides are prepared by using copper thiophenecarboxylate.

A novel method for the synthesis of α,β-unsaturated amides mediated by Samarium diiodide

Promoted by Samarium diiodide (SmI2), α,β-unsaturated amides were formed from nitrogenanions (formed in situ by the reduction of nitro compounds) and αβ-unsaturated esters. This reaction contrasts with the conjugate addition between amines and α,β-unsaturated esters promoted by samarium triiodide (SmI3) and provides an alternative attractive way to obtain α,β-unsaturated amides using SmI 2.

Solid-phase synthesis of 2-alkenamides from polystyrene-supported α-selenocarboxylic acids

The polystyrene-supported α-selenoacetic acid and α-selenopropionic acid were prepared and used for the synthesis of 2-alkenamides from primary and secondary amines in good yields and high purities.

Solid-phase synthesis of acrylamides with polymer-bound 2-sulfonylpropanoic acid

A novel polystyrene-bound 2-sulfonylpropanoic acid has been developed and applied to convenient, traceless synthesis of acrylamides in good yield and purity.

Selenium-linking strategy for traceless solid-phase synthesis of acrylamides

A novel polystyrene-supported β-selenopropionic acid has been developed and applied to simple and efficient synthesis of acrylamides.