625-68-3Relevant articles and documents
HYDROCHLORINATION OF ELECTRON-DEFICIENT ALKENES
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Page/Page column 5, (2012/07/31)
The present invention pertains to a method for the hydrochlorination of electron deficient alkenes, particularly alkenes having the functional groups COOH, CONH2, and CN. Specific alkenes discussed include acrylic acid, crotonic acid, methacrylic acid, acrylonitrile, acrylamide, and methacrylonitrile. The alkene is combined with a primary or secondary alcohol (e.g., isopropanol) and an acid chloride (e.g., acetyl chloride) under conditions suitable to chlorinate the alkene. Products formed by the invention include 3-chorosubstituted carbonyl compounds such as 3-chlorpropionic acid (3-CPA), 3-chloropropionamide (3-CPAD), and 3-chloropropionitrile among other products.
AN IMPROVED SYNTHESIS OF HEXAMETHYLPHENALENE
Boudjouk, Philip,Ohrbom, Walter H.,Woell, James B.
, p. 401 - 410 (2007/10/02)
The synthesis of 1,3,4,6,7,9-hexamethylphenalene (2) has been improved from 15 steps to a four step procedure.The overall yield has been increased from an estimated 5percent to 45percent.Key steps in the synthesis are the reaction of 3,5-dimethylbenzylmagnesium chloride with 2,4-pentanedioato lithium in THF to make 5-(3,5-dimethylphenyl)-4-methyl-4-hydroxy-2-pentanone (5) and the Lewis acid acylation-alkation of 1,3,6,8-tetramethylnaphthalene using 3-chlorobutanoic chloride in hexane with sonicaton to make 1,3,4,6,7,9-hexamethyl-phenalane (2).
Studies on analgesics of aniline series. 3. Preparation and properties of N,N-dialkyl 3-(substituted anilino)butyramide series.
Takamura,Shioya,Yamamoto,Takama,Nitta
, p. 211 - 217 (2007/10/06)
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