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548-77-6

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548-77-6 Usage

Uses

Tectorigenin is identified as an α-glucosidase inhibitors. Potent lactate dehydrogenase (LDH) inhibitor.

Definition

ChEBI: A methoxyisoflavone that is isoflavone substituted by a methoxy group at position 6 and hydroxy groups at positions 5, 7 and 4' respectively.

Synthesis Reference(s)

Synthetic Communications, 38, p. 525, 2008 DOI: 10.1080/00397910701796725

Check Digit Verification of cas no

The CAS Registry Mumber 548-77-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,4 and 8 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 548-77:
(5*5)+(4*4)+(3*8)+(2*7)+(1*7)=86
86 % 10 = 6
So 548-77-6 is a valid CAS Registry Number.
InChI:InChI=1/C16H12O6/c1-21-16-11(18)6-12-13(15(16)20)14(19)10(7-22-12)8-2-4-9(17)5-3-8/h2-7,17-18,20H,1H3

548-77-6 Well-known Company Product Price

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  • Sigma-Aldrich

  • (67359)  Tectorigenin  analytical standard

  • 548-77-6

  • 67359-25MG

  • 5,496.66CNY

  • Detail

548-77-6Relevant articles and documents

Isolation and identification of urinary metabolites of tectoridin in rats

Bai, Xue,Qu, Jia-Lin,Liu, Jia,Sun, Jia-Hong,Yuan, Dan

, p. 604 - 610 (2011)

Tectoridin is an active isoflavone from the rhizome of Belamcanda chinensis and flower of Pueraria thomsonii Benth, possessing an anti-inflammation action and the protective effect against ethanol-induced intoxication and hepatic injury. The metabolism of tectoridin was investigated in rats. Nine metabolites were isolated by using repeated chromatographic methods and identified by spectroscopic methods including UV, IR, mass spectrometry, and NMR experiments. A new compound was determined as tectorigenin-7-O-β-D-glucuronide (M-1), together with eight known compounds identified as irisolidone-7-O-β-D- glucuronide (M-2), tectorigenin-7-O-sulfate (M-3), tectorigenin-4′-O- sulfate (M-4), tectorigenin (M-5), irisolidone (M-6), isotectorigenin (M-7), genistein (M-8), and daidzein (M-9), respectively. The metabolic pathway of tectoridin was proposed, which is important to understand its metabolic fate and disposition in humans.

Cytoprotective effect of tectorigenin, a metabolite formed by transformation of tectoridin by intestinal microflora, on oxidative stress induced by hydrogen peroxide

Kang, Kyoung Ah,Lee, Kyoung Hwa,Chae, Sungwook,Zhang, Rui,Jung, Myung Sun,Kim, So Young,Kim, Hee Sun,Kim, Dong Hyun,Hyun, Jin Won

, p. 16 - 23 (2005)

In the present study, the antioxidative properties of tectorigenin, a metabolite formed by transformation of tectoridin by intestinal microflora, were investigated. Tectorigenin was found to scavenge intracellular reactive oxygen species, and 1,1-diphenyl

Fluorescence spectroscopy and docking study in two flavonoids, isolated tectoridin and its aglycone tectorigenin, interacting with human serum albumin: A comparison study

Li, Yuanzhi,Wang, Qing,He, Jiawei,Yan, Jin,Li, Hui

, p. 38 - 46 (2016)

Two flavonoids, tectoridin (TD) isolated from rhizomes of Iris tectorum and hydrolyzed aglycone tectorigenin (TG) were prepared and characterized to compare their different interaction ability with human serum albumin (HSA). Based on the results, the affi

Efficient method for the synthesis of tectorigenin

Xiao, Zhu-Ping,Li, Huan-Qiu,Xue, Jia-Yu,Shi, Lei,Zhu, Hai-Liang

, p. 525 - 529 (2008/04/12)

Tectorigenin, isolated from the rhizomes of Belamcanda chinensis, shows a wide variety of biological activities. The interest in its biological activities has been matched by a corresponding interest in its synthesis. We herein reported a convenient synth

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