55390-99-3

Upstream product

• 18600-55-0 2-(4-methoxyphenyl)-4H-3,1-benzoxazin-4-one 
• 28005-57-4 N-(2-ethoxycarbonylphenyl)-4-methoxythiobenzamide 
• 55390-95-9 2-(4-methoxybenzoylamino)benzoylhydrazine 
• 100-66-3 methoxybenzene 
• 85094-63-9 2-(4-methoxyphenyl)-4H-3,1-benzothiazin-4-one 
• 134-20-3 2-carbomethoxyaniline 
• 37619-28-6 methyl 2-[(4-methoxybenzoyl)amino]benzoate 
• 100-07-2 4-methoxy-benzoyl chloride 
• 118-92-3 anthranilic acid 
• 16024-82-1 methyl 2-isothiocyanatobenzoate 

Downstream Products

• 1152-07-4 2-(4-methoxyphenyl)-3H-quinazolin-4-one 
• 1414886-86-4 2-(4-methoxyphenyl)-3-{[(3-(pyridin-4-yl)-1-(p-tolyl)-1H-pyrazol-4-yl)methylene]amino}quinazolin-4(3H)-one 
• 69722-13-0 N-(2-(4-methoxyphenyl)-4-oxoquinazolin-3(4H)-yl)benzamide 

Relevant academic research and scientific papers

Asymmetric Synthesis of N-N Axially Chiral Compounds by Phase-Transfer-Catalyzed Alkylations

N-N axially chiral skeletons are significant structural motifs in natural products, pharmaceuticals, and functional materials. Herein we disclose a method for the asymmetric synthesis of N-N axially chiral compounds by phase-transfer catalysis. A wide range of N-N axially chiral quinazolinone derivatives were prepared in high yields with excellent stereoselectivities. Furthermore, the synthetic utility of the protocol was proved by large-scale reaction and transformation of the product. Density functional theory calculations provide insight into the mechanism.

Quinazolinone-schiff's base hybrids as phosphodiesterase 4b inhibitors with dual activity against COPD and lung cancer

A series of thirty compounds of quinazolinone-Schiff's base hybrids were rationally designed, synthesized, and evaluated for their in vitro Phosphodiesterase 4B inhibition, anti-lung and anti-colon cancer activities. Compounds 9, 16, 23, 29, 30, 31, 32 an

Quinazolin-4-one derivatives

A medicament having an inhibitory activity against hematopoietic prostaglandin D2 synthase, which comprises as an active ingredient a compound represented by the following general formula (I) or a salt thereof: wherein X represents a group represented by the formula —N═C(R5)— or the formula —NH—CH(R5)—, R1, R2, R3, and R4 represent a hydrogen atom, a halogen atom, a C1 to C6 alkyl group, or a hydroxy group, R5 represents a C1 to C6 alkyl group or a C6 to C10 aryl group, and R represents an amino group.

Reaction of 2-Aryl-3,1-benzoxazine-4-ones with Hydrazine Hydrate: A Reinvestigation

The reaction of 2-aryl-3,1-benzoxazine-4-ones (I) and hydrazine hydrate in refluxing xylene yields 2-aryl-3-aminoquinazolin-4(3H)-ones (III), instead of 2-aryl-3,4-dihydro-5H-1,3,4-benzotriazepin-5-ones (II).III is also obtained by treating I with hydrazi

A New Synthesis of 2-Aryl-3,4-dihydro-5H-1,3,4-benzotriazepin-5-ones

The reaction of 2-aryl-3,1-benzoxazine-4-ones (1) and hydrazine hydrate in refluxing xylene yields 2-aryl-3,4-dihydro-5H-1,3,4-benzotriazepin-5-ones in 55-74percent yield.In basic conditions this reaction, however, gives 2-aryl-3-aminoquinazolin-4(3H)-one

Synthesis of 4(3H)-Quinazolinones from Derivatives of Methyl 2-Isothiocyanatobenzoate

Ethyl N-((2-methoxycarbonylphenyl)thiocarbamate (2), N-(2-ethoxycarbonylphenyl)-4-methoxythiobenzamide (3b), and 2-(4-methoxyphenyl)4H,-3,1-benzothiazin-4-one (4a), react with nucleophilic reagents containing at least one primary amino group to yield a variety of 2-substituted and 2,4-disubstituted 4(3H)-quinazolinones, as well as some tricyclic and tetracyclic products.