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55406-13-8

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55406-13-8 Usage

Preparation

3-Methylthiophene-2-carbonitrile synthesis: 3-Methyl-2-thiophenecarboxamide (18.6 g, 0.13 mol) was mixed with an excess of POCl3, and the mixture heated at reflux temperature for 2 h. The excess POCl3 was removed under vacuum and the residue dissolved in 500 mL of 1,2-dichloroethane, washed (carefully!) with water, then brine, and the solvent removed to give 23 g of crude 3-methyl-2-thiophenecarbonitrile. This material was passed through a plug of silica gel with CH2Cl2 and the solvent evaporated to give 16.2 g (100%) of as a light tan oil: 1H NMR (CDCl3) d 7.4 (d, J=4.8 Hz, 1H), 6.9 (d, J=5.4 Hz, 1H), 2.4 ppm (s, 3H); 97% pure by HPLC area %.

Check Digit Verification of cas no

The CAS Registry Mumber 55406-13-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,5,4,0 and 6 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 55406-13:
(7*5)+(6*5)+(5*4)+(4*0)+(3*6)+(2*1)+(1*3)=108
108 % 10 = 8
So 55406-13-8 is a valid CAS Registry Number.
InChI:InChI=1/C6H5NS/c1-5-2-3-8-6(5)4-7/h2-3H,1H3

55406-13-8 Well-known Company Product Price

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  • Alfa Aesar

  • (A13305)  3-Methylthiophene-2-carbonitrile, 96%   

  • 55406-13-8

  • 1g

  • 566.0CNY

  • Detail
  • Alfa Aesar

  • (A13305)  3-Methylthiophene-2-carbonitrile, 96%   

  • 55406-13-8

  • 5g

  • 2227.0CNY

  • Detail
  • Alfa Aesar

  • (A13305)  3-Methylthiophene-2-carbonitrile, 96%   

  • 55406-13-8

  • 25g

  • 5303.0CNY

  • Detail

55406-13-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-Methylthiophene-2-Carbonitrile

1.2 Other means of identification

Product number -
Other names 3-METHYLTHIOPHENE-2-CARBONITRILE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:55406-13-8 SDS

55406-13-8Relevant articles and documents

Stable and reusable nanoscale Fe2O3-catalyzed aerobic oxidation process for the selective synthesis of nitriles and primary amides

Murugesan, Kathiravan,Senthamarai, Thirusangumurugan,Sohail, Manzar,Sharif, Muhammad,Kalevaru, Narayana V.,Jagadeesh, Rajenahally V.

supporting information, p. 266 - 273 (2018/01/12)

The sustainable introduction of nitrogen moieties in the form of nitrile or amide groups in functionalized molecules is of fundamental interest because nitrogen-containing motifs are found in a large number of life science molecules, natural products and materials. Hence, the synthesis and functionalization of nitriles and amides from easily available starting materials using cost-effective catalysts and green reagents is highly desired. In this regard, herein we report the nanoscale iron oxide-catalyzed environmentally benign synthesis of nitriles and primary amides from aldehydes and aqueous ammonia in the presence of 1 bar O2 or air. Under mild reaction conditions, this iron-catalyzed aerobic oxidation process proceeds to synthesise functionalized and structurally diverse aromatic, aliphatic and heterocyclic nitriles. Additionally, applying this iron-based protocol, primary amides have also been prepared in a water medium.

Cyclopropenone-catalyzed direct conversion of aldoximes and primary amides into nitriles

Rai, Ankita,Yadav, Lal Dhar S.

, p. 1889 - 1893 (2013/05/08)

Efficient conversion of aldoximes and primary amides into nitriles by employing cyclopropenone as an organocatalyst is reported. The reaction proceeds smoothly under mild conditions with 5 mol-% catalyst loading to afford nitriles in excellent yields (78-94 %) in a single operation. This method is equally applicable to both aldoximes and primary amides bearing aromatic, heterocyclic, and aliphatic moieties. The convenient and catalytic procedure widens the scope of the utilization of cyclopropenones in organic synthesis. Cyclopropenone- catalyzed conversion of aldoximes and primary amides into nitriles in a one-pot procedure is described. The reaction proceeds smoothly under mild conditions with low catalyst loading. The convenient and catalytic procedure widens the scope of the utilization of cyclopropenones in organic synthesis.

ANTIMICROBIAL/ADJUVANT COMPOUNDS AND METHODS

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Page/Page column 66; 67, (2012/09/21)

Among other things, in general, antimicrobial and/or adjuvant compounds are provided according to Formula la: (Ia) in which E and R1-11 have the meanings described herein; and prodrugs and pharmaceutically acceptable salts thereof. Other formulae and methods of use are also provided.

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