55774-20-4

Basic information

• Product Name: 3H-Pyrazol-3-one, 1,2-dihydro-5-methyl-2-phenyl-1-(phenylmethyl)-
• CAS NO: 55774-20-4
• Molecular Formula: C17H16N2O
• Molecular Weight: 264.327
• Mol File: 55774-20-4.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 3H-Pyrazol-3-one, 1,2-dihydro-5-methyl-2-phenyl-1-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 3H-Pyrazol-3-one, 1,2-dihydro-5-methyl-2-phenyl-1-(phenylmethyl)-(55774-20-4)
• EPA Substance Registry System: 3H-Pyrazol-3-one, 1,2-dihydro-5-methyl-2-phenyl-1-(phenylmethyl)-(55774-20-4)

Safety Data

• Hazardous Substances Data: 55774-20-4(Hazardous Substances Data)

Upstream product

• 100-39-0 benzyl bromide 
• 89-25-8 edaravone 
• 620-05-3 iodomethylbenzene 
• 100-63-0 phenylhydrazine 
• 19735-89-8 3-methyl-1-phenylpyrazolin-5(4H)-one 
• 100-44-7 benzyl chloride 

Downstream Products

• 19735-89-8 3-methyl-1-phenylpyrazolin-5(4H)-one 
• 60-80-0 antipyrine 
• 54462-78-1 4-benzyl-5-methyl-2-phenyl-1,2-dihydro-pyrazol-3-one 
• 102-01-2 N-phenylacetoacetamide 
• 62-53-3 aniline 
• 100-46-9 benzylamine 
• 1131-17-5 5-chloro-3-methyl-1-phenyl-1H-pyrazole 
• 100-44-7 benzyl chloride 

Relevant articles and documents

Pd(ii)-Catalyzed alkyne annulation through allylic isomerization: synthesis of spiro-cyclopentadiene pyrazolones

The Pd(ii)-catalyzed activation of Csp2-H bond and double alkyne annulation which proceedsviaallylic isomerization is reported for the first time. This reaction of antipyrines with alkynes provides an efficient synthetic route for the biologically important spiro-cyclopentadiene pyrazolones. In the presence of Lawesson's reagent, this Pd(ii)-catalyzed annulation reaction affords another spiro-cyclopentadiene pyrazolone which displays very good fluorescence properties.

DABCO-catalyzed silver-promoted direct thiolation of pyrazolones with diaryl disulfides

A highly efficient protocol for a direct thiolation of N-substituted pyrazolones with diaryl disulfides is described. Using a combination of DABCO and silver(i) acetate, the C-S bond formation proceeds smoothly at room temperature under mild and easy to handle conditions. This synthetic strategy offers a convenient and direct modification of antipyrine and other pyrazolone substrates, giving a series of aryl sulfide-substituted pyrazolone products in moderate to excellent yields.

Room-temperature direct alkenylation of 5-pyrazolones

A mild and efficient method for the direct alkenylation of 5-pyrazoles by Pd-catalyzed C-H bond activation is described. The reaction smoothly proceeds at room temperature to provide products in up to 92 % yield. Heterocycles containing the 5-pyrazolone moiety are synthesized by an oxidative Heck-type reaction. The direct alkenylation of 5-pyrazolones at room temperature through Pd-catalyzed C-H bond activation is described. Copyright