558-22-5

Basic information

• Product Name: TRIFLUOROMETHANE-D
• Synonyms: TRIFLUOROMETHANE-D;Trifluoromethane-D (gas)
• CAS NO: 558-22-5
• Molecular Formula: CHF₃
• Molecular Weight: 71.02
• Mol File: 558-22-5.mol
• Article Data: 15

Chemical Properties

• Appearance: /
• Density: 1.149 g/cm³
• Vapor Pressure: 25200mmHg at 25°C
• Refractive Index: 1.179
• CAS DataBase Reference: TRIFLUOROMETHANE-D(CAS DataBase Reference)
• NIST Chemistry Reference: TRIFLUOROMETHANE-D(558-22-5)
• EPA Substance Registry System: TRIFLUOROMETHANE-D(558-22-5)

Safety Data

• Hazardous Substances Data: 558-22-5(Hazardous Substances Data)

Usage

General Description

TRIFLUOROMETHANE-D is a stable, colorless, non-flammable gas that contains three isotopes of fluorine. It is commonly used as a refrigerant, either on its own or in combination with other refrigerants, due to its low toxicity and non-reactivity with other chemicals. TRIFLUOROMETHANE-D is also used as a propellant in aerosol products and as a cleaning agent in electronics manufacturing. It has a relatively low boiling point and is chemically stable, making it useful in a variety of industrial applications. However, it is a potent greenhouse gas and has a high global warming potential, so efforts are being made to find more environmentally friendly alternatives.

InChI:InChI=1/CHF3/c2-1(3)4/h1H/i1D

Upstream product

• 2264-21-3 trifluoromethyl radical 
• 24704-57-2 methyl acetate-d₃ 
• 325810-07-9 tris(triphenylphosphane)(trifluoromethyl)copper(I) 
• 811-98-3 d⁽⁴⁾-methanol 
• 766-96-1 4-bromo-1-ethynylbenzene 
• 1680206-12-5 Grushin’s reagent 
• 2206-26-0 [D₃]acetonitrile 
• 887144-94-7 Togni's reagent II 
• 3317-61-1 5,5-Dimethyl-1-pyrroline N-oxide 
• 1665-00-5 dichloromethane-d2 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 79552-31-1 2,2,6,6-tetramethylpiperidine-1-D 
• 865-49-6 chloroform-d1 
• 13536-94-2 deuterium sulfide 

Downstream Products

• 75-46-7 trifluoromethan 
• 13760-79-7 thulium(III) fluoride 
• 13760-78-6 holmium(III) fluoride 
• 13765-26-9 gadolinium(III) fluoride 
• 13760-83-3 erbium(III) fluoride 
• 7758-88-5 cerium(III) fluoride 
• 13709-46-1 praseodymium(III) fluoride 
• 13709-42-7 neodymium(III) fluoride 
• 13709-38-1 lanthanum(III) fluoride 
• 13760-81-1 lutetium(III) fluoride 

Relevant articles and documents

1,2-(Bis)trifluoromethylation of Alkynes: A One-Step Reaction to Install an Underutilized Functional Group

Modifying the electronic properties of olefins is the quintessential approach to tuning alkene reactivity. In this context, the exploration of trifluoromethyl groups as divergent electronic modifiers has not been considered. In this work, we describe a copper-mediated 1,2-(bis)trifluoromethylation of acetylenes to create E-hexafluorobutenes (E-HFBs) under blue light in a single step. The reaction proceeds with high yield and E/Z selectivity. Since the alkyne captures two trifluoromethyl groups from each molecule of bpyCu(CF3)3, mechanistic studies were conducted to illuminate the role of the reactants. Interestingly, E-HFBs exhibit remarkable stability to standard olefin functionalization reactions in spite of the pendant trifluoromethyl groups. This finding has significant implications for medicine, agroscience, and materials.

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Carbon-Carbon Bond-Forming Reductive Elimination from Isolated Nickel(III) Complexes

This manuscript describes the design, synthesis, characterization, and reactivity studies of organometallic NiIII complexes of general structure TpNiIII(R)(R1) (Tp = tris(pyrazolyl)borate). With appropriate selection of th

Silver-mediated trifluoromethylation-iodination of arynes

An unprecedented silver-mediated vicinal trifluoromethylation-iodination of arynes that quickly introduces CF3 and I groups onto aromatic rings in a single step to give o-trifluoromethyl iodoarenes has been developed. A new reactivity of AgCF3 has been revealed, and 2,2,6,6-tetramethylpiperidine plays an important role in this difunctionalization reaction.