5580-33-6

Basic information

• Product Name: 3,4-DIMETHYLBENZAMIDE
• Synonyms: 3,4-DIMETHYLBENZAMIDE;Benzamide, 3,4-dimethyl- (6CI,7CI,8CI,9CI)
• CAS NO: 5580-33-6
• Molecular Formula: C₉H₁₁NO
• Molecular Weight: 149.19
• Product Categories: AMIDE;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
• Mol File: 5580-33-6.mol
• Article Data: 9

Chemical Properties

• Melting Point: 101-103°C
• Boiling Point: 251.3 °C at 760 mmHg
• Flash Point: 105.8 °C
• Appearance: /
• Density: 1.06g/cm³
• Vapor Pressure: 0.0207mmHg at 25°C
• Refractive Index: 1.55
• PKA: 16.32±0.50(Predicted)
• CAS DataBase Reference: 3,4-DIMETHYLBENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-DIMETHYLBENZAMIDE(5580-33-6)
• EPA Substance Registry System: 3,4-DIMETHYLBENZAMIDE(5580-33-6)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 5580-33-6(Hazardous Substances Data)

Usage

General Description

3,4-DIMETHYLBENZAMIDE is a chemical compound with the molecular formula C9H11NO. It is a white crystalline solid that is insoluble in water but soluble in organic solvents. 3,4-DIMETHYLBENZAMIDE is commonly used as a building block in the synthesis of various pharmaceuticals and agrochemicals. It is also utilized as an intermediate in the production of dyes, pigments, and other organic compounds. Additionally, this compound has potential applications in the field of materials science, such as in the development of polymers and functional materials. However, it is important to handle 3,4-DIMETHYLBENZAMIDE with care as it may be harmful if ingested, inhaled, or put in contact with skin and eyes.

InChI:InChI=1/C9H11NO/c1-6-3-4-8(9(10)11)5-7(6)2/h3-5H,1-2H3,(H2,10,11)

Upstream product

• 58161-01-6 N-methoxy-3,4,N-trimethyl-benzamidine 
• 5973-71-7 3,4-dimethylbenzaldehyde 
• 64-18-6 formic acid 
• 31599-61-8 3,4-dimethyliodobenzene 
• 22884-95-3 3,4-dimethylbenzonitrile 
• 15226-74-1 dicobalt octacarbonyl 
• 583-71-1 4-bromo-o-xylene 
• 3637-01-2 3,4-dimethylacetophenone 
• 95-47-6 o-xylene 
• 127099-85-8 N-Cyanoguanidine 
• 1118-02-1 trimethylsilyl isocyanate 
• 6966-10-5 3,4-dimethylbenzyl alcohol 
• 2571-39-3 (3,4-dimethylphenyl)(phenyl)methanone 
• 71-43-2 benzene 

Downstream Products

• 2198-54-1 N-(3,4-dimethylphenyl)acetamide 
• 333348-33-7 N-benzyl-3,4-dimethylbenzamide 
• 1404499-95-1 6,7-dimethyl-3,4-diphenylisoquinolin-1(2H)-one 
• 1650579-70-6 (3,4-dimethylphenyl)(2-phenylaziridin-1-yl)methanone 
• 897796-35-9 2-(3,4-dimethylphenyl)-1H-benzo[d]imidazole 
• 851225-16-6 5-(3,4-dimethyl-phenyl)-[1,3,4]oxathiazol-2-one 
• 1163-75-3 5-benzyl-2-(3,4-dimethyl-phenyl)-[1,3]oxazine-4,6-dione 
• 22884-95-3 3,4-dimethylbenzonitrile 

Relevant articles and documents

Efficient nitriding reagent and application thereof

The invention discloses an efficient nitriding reagent and application thereof, wherein the nitriding reagent comprises nitrogen oxide, an active agent, a reducing agent and an organic solvent. By applying the nitriding reagent, nitrogen-containing compounds such as amide, nitrile and the like can be produced, and the method is simple in condition, low in waste discharge amount and simple in reaction equipment.

A Convenient Palladium-Catalyzed Aminocarbonylation of Aryl Iodides to Primary Amides under Gas-Free Conditions

A convenient procedure for the synthesis of aromatic primary amides through palladium-catalyzed aminocarbonylation of aryl iodides has been developed. With ammonium hydrogen carbonate as the solid nitrogen source and formic acid as the liquid CO source, a variety of primary amides were obtained in moderate to excellent yields under gas-free conditions.

Synthesis of primary amides by aminocarbonylation of aryl/hetero halides using non-gaseous NH3 and CO sources

Abstract A practically simple method for the synthesis of primary amides via the palladium-catalysed aminocarbonylation of aromatic halides by using solid sources of gaseous ammonia and carbon monoxide is described. The system tolerated a wide variety of hindered and functionalized aryl/hetero halides and afforded good to excellent yields (69-94%) of the amide. Pharmacologically active Exalamide and Pyrazinecarboxamide were synthesised in high yields to demonstrate the effectiveness of this method.