31431-19-3

Basic information

• Product Name: 4-Amino-3-nitrobenzophenone
• Synonyms: TIMTEC-BB SBB000820;LABOTEST-BB LT00455419;4-AMINO-3-NITROBENZOPHENONE;(4-AMINO-3-NITROPHENYL)PHENYLMETHANONE;3-NITRO-4-AMINOBENZOPHENONE;(4-Amino-3-nitrophenyl)phenyl-;4-AMINO-3-NITROBENZOPHENONE=99.0%;4-Amino-3-nitrobenzophenone, 98+%
• CAS NO: 31431-19-3
• Molecular Formula: C₁₃H₁₀N₂O₃
• Molecular Weight: 242.23
• EINECS: 250-631-2
• Product Categories: Aromatic Benzophenones & Derivatives (substituted);C13 to C14;Carbonyl Compounds;Ketones
• Mol File: 31431-19-3.mol
• Article Data: 10

Chemical Properties

• Melting Point: 140-143 °C(lit.)
• Boiling Point: 385.05°C (rough estimate)
• Flash Point: 225.8 °C
• Appearance: yellow powder
• Density: 1.2480 (rough estimate)
• Vapor Pressure: 2.8E-08mmHg at 25°C
• Refractive Index: 1.5300 (estimate)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: -2.67±0.10(Predicted)
• Water Solubility: 10 mg/L (20 ºC)
• BRN: 2216543
• CAS DataBase Reference: 4-Amino-3-nitrobenzophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Amino-3-nitrobenzophenone(31431-19-3)
• EPA Substance Registry System: 4-Amino-3-nitrobenzophenone(31431-19-3)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 26-37/39-36
• WGK Germany: 3
• Hazardous Substances Data: 31431-19-3(Hazardous Substances Data)

Usage

Chemical Properties

YELLOW POWDER

Uses

4-Amino-3-nitrobenzophenone is a useful intermediate for the preparation of benzimidazoles, imidazolopyridines and other imidazole containing heterocyclic ring systems.

InChI:InChI=1/C13H10N2O3/c14-11-7-6-10(8-12(11)15(17)18)13(16)9-4-2-1-3-5-9/h1-8H,14H2

Upstream product

• 56107-03-0 4-bromo-3-nitrobenzophenone 
• 453-71-4 3-nitro-4-fluorobenzoic acid 
• 400-94-2 4-fluoro-3-nitrobenzoyl chloride 
• 82571-93-5 (4-fluoro-3-nitrophenyl)(phenyl)methanon 
• 96-99-1 4-chloro-3-nitrobenzoate 
• 74-11-3 para-chlorobenzoic acid 
• 106-43-4 para-chlorotoluene 
• 38818-50-7 4-chloro-3-nitro-benzoyl chloride 
• 71-43-2 benzene 
• 335015-51-5 4-bromo-3-nitrobenzoyl chloride 
• 98-07-7 Benzotrichlorid 
• 134919-56-5 Methyl N-(4-benzoylphenyl)carbamate 
• 2603-10-3 N-phenyl methyl carbamate 
• 4834-61-1 N-(4-benzoylphenyl)acetamide 

Downstream Products

• 90044-01-2 1-(4-amino-3-nitrophenyl)-1-phenylethylene 
• 1579294-27-1 (3-nitro-4-(phenylselanyl)phenyl)(phenyl)methanone 
• 1072139-12-8 [4-(2-methyl-1-propenylamino)-3-nitrophenyl]phenylmethanone 
• 610316-83-1 4β-1''-[4''-(benzoyl)-2''-nitroanilino]-4-desoxypodophyllotoxin 
• 610316-84-2 4'-O-demethyl-4β-1''-[4''-(benzoyl)-2''-nitroanilino]-4-desoxypodophyllotoxin 
• 53502-23-1 4-acetamido-3-nitrobenzophenone 
• 87200-79-1 2-(4-Benzoyl-2-nitrophenylamino)benzothiazole 
• 87200-53-1 (4-Isothiocyanato-3-nitro-phenyl)-phenyl-methanone 
• 39070-63-8 4-benzoylbenzene-1,2-diamine 
• 111797-45-6 benzoic acid-(4-benzoyl-2-nitro-anilide) 

Relevant articles and documents

Preparation method of 3-acetylindole BRPF1 inhibitor and use of 3-acetylindole BRPF1 inhibitor

The invention relates to a 3-acetylindole compound of a novel structure shown in a formula (I), a pharmaceutically acceptable salt thereof, a prodrug thereof, a hydrate or a solvate thereof, a preparation method of the compound, a pharmaceutical composition containing a therapeutically effective dose of the compound, and use thereof as a protein tyrosine kinase inhibitor, especially as a bromine-containing area PHD zinc finger protein 1 (BRPF1) inhibitor, in the prevention or treatment of disease benefited from the inhibition of BRPF1.

Zinc Mediated Friedel-Crafts Acylation in Solvent-Free Conditions under Microwave Irradiation

Zn powder is found to catalyze the Friedel-Crafts acylation of aromatic compounds with acyl halides efficiently under microwave irradiation in solvent-free conditions. Activated substrates undergo acylation predominantly at the para-position. The Zn powder can be re-used up to six times after simple washing with diethyl ether and dilute HCl.

AN ALTERNATE SYNTHESIS OF 3,4-DIAMINOBENZOPHENONE AND OF MEBENDAZOLE

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