56227-55-5

Basic information

• Product Name: 1-BENZOYLPIPERAZINE HYROCHLORIDE 97
• Synonyms: 1-BENZOYLPIPERAZINE HYROCHLORIDE 97;1-BENZOYLPIPERAZINE HYROCHLORIDE, 97%;1-BENZOYLPIPERAZINE HYROCHLORIDE 97%;Piperazine, 1-benzoyl-, Monohydrochloride;Methanone, phenyl-1-piperazinyl-, hydrochloride (1:1);1-Benzoylpiperazine monohydrochloride;4-Benzoylpiperazine hydrochloride;Benzoylpiperazine hydrochloride
• CAS NO: 56227-55-5
• Molecular Formula: C₁₁H₁₄N₂O*ClH
• Molecular Weight: 226.7026
• Product Categories: Building Blocks;Heterocyclic Building Blocks;Piperazines;Building Blocks;C11;Chemical Synthesis;Heterocyclic Building Blocks
• Mol File: 56227-55-5.mol
• Article Data: 10

Chemical Properties

• Melting Point: >230 °C(lit.)
• Boiling Point: 370.9°C at 760 mmHg
• Flash Point: 178.1°C
• Appearance: /
• Vapor Pressure: 7.34E-06mmHg at 25°C
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 1-BENZOYLPIPERAZINE HYROCHLORIDE 97(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BENZOYLPIPERAZINE HYROCHLORIDE 97(56227-55-5)
• EPA Substance Registry System: 1-BENZOYLPIPERAZINE HYROCHLORIDE 97(56227-55-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 56227-55-5(Hazardous Substances Data)

Usage

General Description

1-Benzoypiperazine hydrochloride 97 is a chemical compound with the formula C11H13ClN2O2. It is a white to off-white solid with a purity of 97% and is commonly used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. This chemical is stable under normal conditions and is not considered to be a significant health hazard. However, it should be handled with care and stored in a cool, dry place away from heat and moisture. 1-Benzoypiperazine hydrochloride 97 is a versatile and valuable compound in the field of organic chemistry.

InChI:InChI=1/C11H14N2O.ClH/c14-11(10-4-2-1-3-5-10)13-8-6-12-7-9-13;/h1-5,12H,6-9H2;1H

Upstream product

• 98-88-4 benzoyl chloride 
• 65-85-0 benzoic acid 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 
• 57238-77-4 4-benzoyl-1-piperazinecarboxaldehyde 
• 10364-94-0 1-benzoylimidazole 
• 64-17-5 ethanol 
• 142-64-3 piperazine dihydrochloride 
• 77278-38-7 4-benzoylpiperazine-1-carboxylic acid tert-butyl ester 
• 39585-46-1 methylene-bis-4-(1-benzoylpiperazine) 

Downstream Products

• 1323405-84-0 3-{4-[4-(4-Benzoyl-piperazin-1-ylmethyl)-benzyloxy]-1-oxo-1,3-dihydro-isoindol-2-yl}-piperidine-2,6-dione 
• 131762-69-1 1-benzoyl-4-(β-hydroxyethyl)piperazine hydrochloride 
• 60013-07-2 1,1'-propane-1,3-diylbis(4-benzoylpiperazine) 
• 1392514-37-2 C₃₁H₂₈ClN₇O₄S 
• 701213-41-4 1-(4-benzoylpiperazin-1-yl)-2-(7-(3-ethyl-1H-1,2,4-triazol-1-yl)-4-methoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione 
• 701213-36-7 1-(4-benzoylpiperazin-1-yl)-2-(4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)-ethane-1,2-dione 
• 56227-56-6 (4-(2-hydroxyethyl)piperazin-1-yl)(phenyl)methanone 
• 1449413-23-3 1-(4-benzoylpiperazin-1-yl)-2-(7-bromo-4-methoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione 
• 446285-02-5 1-(4-benzoylpiperazin-1-yl)-2-(7-chloro-4-methoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione 
• 1569642-27-8 C₂₄H₂₃N₅O₂ 
• 885884-05-9 2-(4-benzoylpiperazin-1-yl)-5,6,7,8-tetrahydro-3H-quinazolin-4-one 
• 446290-68-2 C₂₃H₁₈FN₅O₄ 
• 959321-17-6 C₂₁H₁₈FN₅O₄ 

Relevant articles and documents

Design and synthesis of the 4H-chromenone derivatives against psoriasis

On basis of Quercetin moiety, two series of 20 new compounds were designed and synthesized accordingly in this study, and their anti-inflammatory activities in vitro and in vivo were evaluated. At last, compound 8A2: 3- (1- (2- (4- (5-bromo-2-chlorobenzoyl) piperazin-1-yl) ethyl)-1H-1,2,3-triazol-4-yl) methoxy)-5,7-dimethoxy-2-(3,4,5-trimethoxyphenyl)-4H-chromen-4-one with low toxicity was found the best one for inhibiting of NO. Meanwhile, this compound could significantly inhibit the expression of IL-6 (Interleukin-6), TNF-α (Tumor necrosis factor-α) and IL-17 (Interleukin-17), and also significantly down-regulate IL-17 mRNA psoriasis model in vitro. Further studies were performed to establish mouse psoriasis model induced by Imiquimod (IMQ), and the preliminary mechanism indicated that compound 8A2 may alleviate mouse psoriasis through obstructed the JAK1/2-STAT1/3 pathway. This study should be provide a basis for further study of effective treatment of psoriasis.

INHIBITORS OF PSEUDOMONAS AERUGINOSA VIRULENCE

Disclosed are piperazine derivative compounds, particularly piperazine derivative compounds having a structure of Formula (I) and methods for preparing these compounds. Also disclosed are use of a therapeutically effective amount of the compound of Formula (I) or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition therefore for inhibiting quorum sensing of a bacteria.

C-3 NOVEL TRITERPENE WITH C-17 AMINE DERIVATIVES AS HIV INHIBITORS

The present invention relates to to C-3 novel triterpene with C-17 amine derivatives of formula (I); or pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, prodrugs, compositions or combination thereof, wherein R1, R2, R3, R4, R5 and 'n' are as defined herein. The present invention also relates to pharmaceutical compositions comprising compounds of formula (I) and process for preparing them, and their use for the treatment of viral diseases and particularly HIV mediated diseases.