56239-25-9

Usage

Uses

Used in Pharmaceutical Industry:
2-Oxa-3-aza-bicyclo[2.2.2]oct-5-ene hydrochlorate is used as a key intermediate for the synthesis of biologically active compounds due to its ability to contribute to the development of new drugs with various pharmacological properties.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 2-Oxa-3-aza-bicyclo[2.2.2]oct-5-ene hydrochlorate is utilized for the development of new drugs, leveraging its pharmacological activities to create innovative therapeutic agents.
Used in Anti-inflammatory Applications:
2-Oxa-3-aza-bicyclo[2.2.2]oct-5-ene hydrochlorate is employed as an anti-inflammatory agent, helping to reduce inflammation and associated symptoms, which can be beneficial in treating a range of conditions.
Used in Analgesic Applications:
As an analgesic, 2-Oxa-3-aza-bicyclo[2.2.2]oct-5-ene hydrochlorate is used to alleviate pain, providing relief in various medical and therapeutic contexts.
Used in Antibacterial Applications:
With its antibacterial properties, 2-Oxa-3-aza-bicyclo[2.2.2]oct-5-ene hydrochlorate is applied in the development of antimicrobial agents to combat bacterial infections.

InChI:InChI=1/C6H9NO/c1-3-6-4-2-5(1)7-8-6/h1,3,5-7H,2,4H2

Upstream product

• 695-64-7 1-chloro-1-nitrosocyclohexane 
• 1165952-91-9 cyclohexa-1,3-diene 
• 740798-68-9 acetic acid 2,2-dimethyl-5-nitroso-[1,3]dioxan-5-yl ester 

Downstream Products

• 71199-02-5 2-oxa-3-aza-bicyclo[2.2.2]oct-5-ene-3-carboxylic acid ethyl ester 
• 110590-29-9 tert-butyl 2-oxa-3-azabicyclo[2.2.2]oct-5-ene-3-carboxylate 
• 551000-83-0 tert-butyl (+/-)-(1S,4R)-(4-hydroxycyclohex-2-enyl)carbamate 
• 77803-77-1 (1S*,4R*)-4-aminocyclohex-2-enol 
• 77803-78-2 cis-1-Acetamido-2-cyclohexen-4-ylacetat 
• 124707-09-1 (E)-2-tert-Butylsulfanyl-3-(4-hydroxy-cyclohexylamino)-acrylonitrile 
• 110590-00-6 N-(trifluoroacetyl)-2-oxa-3-azabicyclo<2.2.2>octane 
• 110589-97-4 N-(carbomethoxy)-2-oxa-3-azabicyclo<2.2.2>octane 
• 87013-23-8 N-acetyl-2-oxa-3-azabicyclo<2.2.2>octane 
• 124707-05-7 (1R,4S)-3-Benzenesulfonyl-2-oxa-3-aza-bicyclo[2.2.2]oct-5-ene 
• 124707-04-6 (1R,4S)-3-(2,4-Dinitro-phenyl)-2-oxa-3-aza-bicyclo[2.2.2]oct-5-ene 
• 77803-76-0 N-acetyl-2-oxa-3-azabicyclo<2.2.2>oct-5-ene 
• 110658-87-2 N-(trifluoroacetyl)-2-oxa-3-azabicyclo<2.2.2>oct-5-ene 
• 56239-26-0 (1s,4s)-4-aminocyclohexan-1-ol hydrochloride 

Relevant academic research and scientific papers

α-Acyloxynitroso dienophiles in [4+2] hetero Diels-Alder cycloadditions: mechanistic insights

α-Acyloxynitroso derivatives are a class of heterodienophiles leading to valuable 3,6-dihydro-1,2-oxazines or the corresponding aminoalcohols in good yields. The discovery that a β-oxygenated moiety led to a domino [4+2] cycloaddition/σN-O bond cleavage in the presence of a catalytic amount of Lewis acid was investigated in detail, through kinetic profiling of the reaction both in the absence and presence of a promoter. These studies showed that the role of the Lewis acid was to accelerate the σN-O bond cleavage thereby promoting a highly reproducible sequence. In addition, our preliminary results on an asymmetric version of this domino sequence are reported.

Intermolecular nitroso Diels-Alder cycloaddition of α-acetoxynitroso derivatives in aqueous medium

The Diels-Alder cycloadditions of the α-acetoxynitroso dienophile 1 in water are reported. The rapid and high yielding synthesis of structurally diverse 3,6-dihydro-1,2-oxazines complements the straightforward elaboration of aminoalcohols obtained from th

Polyhydroxyamino Compounds via Diene Synthesis with Nitroso Compounds, IV. - Preparation and Stereochemistry of Dideoxyinosamine Derivatives

The general method for the synthesis of polyhydroxy amines by Diels-Alder reactions with a nitroso compound, reduction of the adduct with cleavage of the N - O bond and hydroxylation of the remaining C = C -double bond, can also be realized with α-chloronitrosocyclohexane as dienophile, in good yield.Primary amines are synthesized in this way.