56352-85-3Relevant academic research and scientific papers
Isonicotinic acid hydrazide derivatives: Synthesis, antimicrobial activity, and QSAR studies
Judge, Vikramjeet,Narasimhan, Balasubramanian,Ahuja, Munish,Sriram, Dharmarajan,Yogeeswari, Perumal,De Clercq, Erik,Pannecouque, Christophe,Balzarini, Jan
, p. 1451 - 1470 (2012/09/22)
A series of isonicotinic acid hydrazide derivatives (1-19) was synthesized and tested in vitro for antimycobacterial activity against Mycobacterium tuberculosis and antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Candida albicans, and Aspergillus niger and the results indicated that the compounds with OH, SCH3, and OCH 3 groups were found to be active against the tested strains. None of the test compounds were active against a broad variety of RNA and DNA viruses at subtoxic concentrations, except 8, that showed some selective anti-reovirus-1 activity. The multi-target QSAR models were found to be effective in predicting the antimicrobial activity of the isoniazid derivatives and indicated the importance of nuclear repulsion energy (Nu.E) in explaining the antimicrobial activity of isoniazid derivatives. The developed QSAR models were validated using the external test set of synthesized derivatives. Springer Science+Business Media, LLC 2011.
Synthesis and characterization of 1,3,4-oxadiazole-triazolopyridinone hybrid derivatives as new blue-greenish photoluminescent materials
Chiang, Kuo-Chen,Fung, Fuh Wong,Chang, Chih-Shiang,Hour, Mann-Jen,Wang, Yu-Ling,Wen, Shaw-Bing,Yeh, Mou-Yung
, p. 591 - 596 (2008/09/18)
(Chemical Equation Presented) Recently, New functionalized oxadiazole-triazolopyridinone hybrid compounds were investigated as photoluminescent materials. In this work, we introduce triazolopyridinone to synthesize a series of oxadiazole-triazolopyridinon
