90017-07-5

Upstream product

• 90017-04-2 Isonicotinic acid [1-(4-chloro-phenyl)-1-cyano-meth-(Z)-ylidene]-hydrazide 
• 54-85-3 isoniazid 
• 104-88-1 4-chlorobenzaldehyde 
• 827-72-5 4-chlorobenzimidic acid ethyl ester 
• 637-87-6 1-Chloro-4-iodobenzene 
• 119072-55-8 tert-butylisonitrile 
• 108-89-4 picoline 
• 536-40-3 4-chlorobenzoic acid hydrazide 
• 872-85-5 pyridine-4-carbaldehyde 
• 56352-85-3 4-chlorobenzoic acid (pyridine-4-carbonyl)hydrazide 
• 623-03-0 4-Cyanochlorobenzene 
• 13915-60-1 O-ethyl 4-chlorobenzenecarbothioate 
• 74-11-3 para-chlorobenzoic acid 

Downstream Products

• 943861-02-7 2-phenyl-7-(5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one 
• 943861-03-8 2-(4-methylphenyl)-7-(5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one 
• 943861-04-9 2-(4-methoxyphenyl)-7-(5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one 

Relevant academic research and scientific papers

The preparation, characterization and catalytic activity of Ni NPs supported on porous alginate-g-poly(p-styrene sulfonamide-co-acrylamide)

Herein, we report the synthesis of nickel nanoparticles under mild conditions using porous alginate-g-poly(p-styrene sulfonamide-co-acrylamide) as a protecting/stabilizing agent and sodium borohydride as a reducing agent. The porous cross-linked polymeric support was preparedviacombining the use of sol-gel, nanocasting, and crosslinking techniques, in which thep-styrene sulfonamide monomer (PSSA) andN,N′-methylene-bis (acrylamide) (MBA) cross-linker underwent copolymerization on the surface of sodium alginate in the presence of a SiO2nanoparticle (NP) template (Alg-PSSA-co-ACA). The prepared catalyst (Alg-PSSA-co-ACA@Ni) showed high catalytic activity for the one-step synthesis of 1,3,4-oxadiazoles from the reaction of hydrazides and aryl iodides through isocyanide insertion/cyclization.

Iodine-promoted one-pot synthesis of 1,3,4-oxadiazole scaffolds: Via sp3 C-H functionalization of azaarenes

An efficient iodine-mediated one-pot synthetic protocol for the synthesis of 2,5-disubstituted 1,3,4-oxadiazole scaffolds has been developed via sp3 C-H functionalization. Gratifyingly, this method involves oxidative amination with concomitant base-mediated cyclization of methylhetarenes and acylhydrazines by employing iodine and Cs2CO3. The key features of the present method include good functional group tolerance, a clean protocol, metal-free conditions and high yields, making this protocol an attractive strategy towards the synthesis of bioactive molecules and their key building blocks.

2,5-Diaryl-1,3,4-oxadiazoles as selective COX-2 inhibitors and anti-inflammatory agents

A new series of compounds comprising of 2,5-diaryl-1,3,4-oxadiazoles was synthesized and evaluated as potential COX-2 inhibitors. Compounds 6b, 6e, 6f, 7e and 7f were found to be the most potent and selective inhibitors of COX-2 (IC50 = 0.48-0.89 μM; SI = 67.96-132.83). Compounds 6e, 6f and 7f displayed anti-inflammatory activity superior to celecoxib in a carrageenan-induced rat paw edema assay. Structure-activity relationship analysis suggested that the compounds with methylsulfonyl moieties lead to more selective inhibition of COX-2, which is well supported by molecular docking studies. Cytotoxicity studies of the most potent compounds in RAW 264.7 and J774A.1 cells revealed cell viabilities of more than 89% when tested at the concentration of 30 μM. This journal is

One-pot, three component synthesis of 2,5-disubstituted 1,3,4-oxadiazoles catalyzed by heteropolyacid

H6[PMo9V3O40] was used as an efficient catalyst for the preparation of 1-aroyl-2-arylidene hydrazines. 2,5-Disubstituted 1,3,4-oxadiazoles have been synthesized by oxidation of 1-aroyl-2-arylidene hydrazines with CrO3 in excellent yields.

Synthesis and biological screening of Some 1,3,4-oxadiazoles

Treatment of Schiff bases with yellow mercuric oxide and iodine in DMF medium yields the title compounds 1,3,4-oxadiazoles (4a-j). The structures of the newly synthesized compounds were assigned on the basis of IR, 1H NMR, Mass spectral data and elemental analysis. All the new compounds were evaluated for their in vitro antibacterial and antifungal activity. Some of the new compounds showed good activity against some bacteria when compared with the standard drug.

Comparison between antioxidant activity of 2,5-disubstituted 1,3,4-oxadiazoles containing heteroaromatic ring and aromatic ring at 2nd position

A series of 4-[5-(substitutedphenyl)-1,3,4-oxadiazol- 2-yl]-pyridine) and 2-[5-substitutedphenyl)-1,3,4- oxadiazol-2-yl]-benzenamine derivatives were synthesized from substituted esters and hydrazine hydrate in the presence of ethanol to give isonicotinic acid hydrazide and 2-aminobenzohydrazide followed by reaction with phosphorus oxychloride and various aromatic acids. All the compounds were tested for their in vitro antioxidant activity by 1,1-diphenyl-2-picryl hydrazyl (DPPH) method. Compounds containing aromatic group at 2nd position showed significant activity as compared to standard (ascorbic acid) which concludes that the presence of aromatic group increases the free radical scavenging activity. Springer Science+Business Media, LLC 2010.

Trichloroisocyanuric acid-mediated one-pot synthesis of unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles at ambient temperature

An efficient method for the one-pot synthesis of unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles has been developed using trichloroisocyanuric acid (TCCA) at ambient temperature. A wide variety of aromatic as well as heterocyclic aldehydes exhibit condensation with a variety of acylhydrazines followed by oxidative cyclization to yield corresponding unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles. The mild nature of the synthesis and short reaction time are notable advantages of the developed protocol. Copyright Taylor & Francis Group, LLC.

Synthesis and characterization of 1,3,4-oxadiazole-triazolopyridinone hybrid derivatives as new blue-greenish photoluminescent materials

(Chemical Equation Presented) Recently, New functionalized oxadiazole-triazolopyridinone hybrid compounds were investigated as photoluminescent materials. In this work, we introduce triazolopyridinone to synthesize a series of oxadiazole-triazolopyridinon

A facile procedure for the one-pot synthesis of unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles

Unsymmetrically 2,5-disubstituted 1,3,4-oxadiazoles were efficiently synthesized from the cyclization-oxidation reaction of acyl hydrazones. Also, the synthesis of the title compounds was achieved by the condensation of acyl hydrazides and aromatic aldehydes in the presence of ceric ammonium nitrate in dichloromethane.

Iodobenzene diacetate mediated solid-state synthesis of heterocyclyl-1,3,4-oxadiazoles

A simple and efficient method has been developed for the oxidation of various heterocyclyl acylhydrazones 3 with iodobenzene diacetate (IBD) to heterocyclyl-1,3,4-oxadiazoles 4 in solid state. The reaction took place at room temperature within few minutes. The products were isolated by simple aqueous work-up in good yields.