5676-57-3

Basic information

• Product Name: 5-METHOXY-2-METHYLBENZODOXAZOLE
• Synonyms: 5-METHOXY-2-METHYLBENZOXAZOLE;5-METHOXY-2-METHYLBENZODOXAZOLE;5-METHOXY-2-METHYL-1,3-BENZOXAZOLE
• CAS NO: 5676-57-3
• Molecular Formula: C₉H₉NO₂
• Molecular Weight: 163.17
• EINECS: 227-134-4
• Mol File: 5676-57-3.mol
• Article Data: 15

Chemical Properties

• Melting Point: 32-34℃ (ethyl ether hexane )
• Boiling Point: 250 °C at 760 mmHg
• Flash Point: 105 °C
• Appearance: /
• Density: 1.166 g/cm³
• Vapor Pressure: 0.0351mmHg at 25°C
• Refractive Index: 1.571
• CAS DataBase Reference: 5-METHOXY-2-METHYLBENZODOXAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-METHOXY-2-METHYLBENZODOXAZOLE(5676-57-3)
• EPA Substance Registry System: 5-METHOXY-2-METHYLBENZODOXAZOLE(5676-57-3)

Safety Data

• Hazardous Substances Data: 5676-57-3(Hazardous Substances Data)

Usage

General Description

5-Methoxy-2-methylbenzodooxazole is a chemical compound with the formula C10H9NO3, featuring an benzodooxazole backbone. It is an organic compound that is typically used in various applications in the scientific and industrial sectors, particularly in the synthesis of other complex organic molecules. The derivatives of this compound have bioactive properties and are of interest in medicinal chemistry. Due to its methoxy and methyl groups, this compound exhibits different reactivity than its parent benzodooxazole, making it highly valuable in advanced organic synthesis. It is important in chemical research as it can be used as a building block to create more complex molecules or tested for potential biological activities.

InChI:InChI=1/C9H9NO2/c1-6-10-8-5-7(11-2)3-4-9(8)12-6/h3-5H,1-2H3

Upstream product

• 20734-76-3 2-amino-4-methoxyphenol 
• 1445-45-0 Trimethyl orthoacetate 
• 1568-70-3 4-methoxy-2-nitrophenol 
• 123-54-6 acetylacetone 
• 705-15-7 1-(2-hydroxy-5-methoxyphenyl)ethan-1-one 
• 149-73-5 trimethyl orthoformate 
• 3934-97-2 4-methoxycatechol 
• 75-04-7 ethylamine 
• 67-56-1 methanol 
• 19219-99-9 2-methyl-5-chlorobenzoxazole 
• 91-66-7 N,N-diethylaniline 
• 55682-66-1 deca-1,3-diyne 
• 23997-82-2 2,5-dimethoxyphenyl methyl ketone oxime 
• 108-24-7 acetic anhydride 

Downstream Products

• 61309-89-5 5-methoxy-2-[4-(2-phenyl-2H-[1,2,3]triazol-4-yl)-styryl]-benzooxazole 
• 61519-91-3 5-methoxy-2-[4-(4-phenyl-[1,2,3]triazol-2-yl)-styryl]-benzooxazole 

Relevant articles and documents

METHODS AND COMPOSITIONS FOR MODULATING SPLICING

Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.

Pd-Catalyzed Cross-Coupling Reactions Promoted by Biaryl Phosphorinane Ligands

We report the use of biaryl phosphorinanes as ligands for Pd-catalyzed cross-coupling reactions. A modular synthesis was developed that employs a double conjugate addition of primary biaryl phosphines into 1,1,5,5-tetraalkyl penta-1,4-diene-3-ones. Notably, this synthesis does not require the use of copper, a known contaminant in structurally related biaryl phosphane ligands. Using the synthetic strategy described above, we synthesized a library of biaryl phosphorinanes, varying their substitution about phosphorus and the steric and electronic nature of the biaryl motif. We then benchmarked their performance as ligands in Pd-catalyzed cross coupling reactions such as aryl sulfonamidation, aryl alkoxylation, and aryl amination in the presence of soluble organic bases. In each reaction studied, many ligands outperformed biaryl phosphanes known to promote the given transformation. Detailed substrate scopes were determined using high-throughput screening technology. Several biaryl phosphorinanes and their corresponding Pd(II) oxidative-addition complexes were extensively characterized using NMR spectroscopy and X-ray crystallography. General observations support that biaryl phosphorinanes promote reductive elimination and form robust catalysts with palladium. In many cases the use of these biaryl phosphorinanes may be advantageous over the use of biaryl phosphanes with respect to lower catalyst loadings, shorter reaction times, and robustness.

Synthesis of benzoxazoles from 2-aminophenols and β-diketones using a combined catalyst of br?nsted acid and copper iodide

Cyclization reactions of 2-aminophenols with β-diketones catalyzed by a combination of Br?nsted acid and CuI are presented. Various 2-substituted benzoxazoles were obtained through these reactions. Different substituents such as methyl, chloro, bromo, nitro, and methoxy on 2-aminophenol are tolerated under the optimized reaction conditions.