57021-26-8

Basic information

• Product Name: 3,5-Pyridinedicarbonitrile, 2-amino-6-methoxy-4-phenyl-
• Synonyms: HMS1558E17;2-Amino-3,5-dicyan-6-methoxy-4-phenyl-pyridin;2-amino-3,5-dicyano-6-methoxy-4-phenylpyridine;4-Phenyl-2-amino-3,5-dicyano-6-methoxypyridin;2-Amino-6-methoxy-4-phenyl-pyridin-3,5-dicarbonitril;2-amino-6-methoxy-4-phenyl-pyridine-3,5-dicarbonitrile
• CAS NO: 57021-26-8
• Molecular Formula: C14H10N4O
• Molecular Weight: 250.26
• Mol File: 57021-26-8.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 3,5-Pyridinedicarbonitrile, 2-amino-6-methoxy-4-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-Pyridinedicarbonitrile, 2-amino-6-methoxy-4-phenyl-(57021-26-8)
• EPA Substance Registry System: 3,5-Pyridinedicarbonitrile, 2-amino-6-methoxy-4-phenyl-(57021-26-8)

Safety Data

• Hazardous Substances Data: 57021-26-8(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 2700-22-3 Benzylidenemalononitrile 
• 124-41-4 sodium methylate 
• 100-52-7 benzaldehyde 
• 109-77-3 malononitrile 
• 93516-34-8 N-acetyl-N-(3,5-dicyano-6-methoxy-4-phenyl-pyridin-2-yl)acetamide 
• 96583-92-5 6-amino-2-chloro-4-phenylpyridine-3,5-dicarbonitrile 

Downstream Products

• 93516-44-0 2-chloro-6-methoxy-4-phenylpyridine-3,5-dicarbonitrile 
• 1263199-61-6 5-amino-2-methoxy-4-phenyl-6,7,8,9-tetrahydrobenzo[b][1,8]naphthyridine-3-carbonitrile 
• 64541-15-7 2-hydroxy-6-methoxy-4-phenylpyridine-3,5-dicarbonitrile 
• 97119-07-8 C₂₆H₁₈N₈O₃ 
• 97119-06-7 C₂₃H₂₀N₈O₃ 
• 97119-04-5 C₂₀H₁₃N₇O₄ 
• 97118-98-4 2-amino-6-benzylamino-4-phenylpyridine-3,5-dicarbonitrile 
• 82072-11-5 isopropyl N-(3,5-dicyano-4-phenyl-6-methoxy-2-pyridyl)carbamate 
• 93516-38-2 N-(3,5-Dicyano-6-methoxy-4-phenyl-pyridin-2-yl)-formimidic acid ethyl ester 
• 97118-97-3 2-amino-6-(butylamino)-4-phenylpyridine-3,5-dicarbonitrile 
• 82072-09-1 methyl N-(3,5-dicyano-4-phenyl-6-methoxy-2-pyridyl)carbamate 

Relevant articles and documents

Structural investigation, Hirshfeld surface analysis and quantum mechanical study of two dicyanopyridine derivatives

Two dicyanopyridine derivatived compounds (I) (C14H10N4) and (II) (C15H16N4) were synthesized with high yields from each reaction of benzylidene malononitrile with dichloride zinc directly in methanol or ethanol solvent. Both the compounds were characterized by NMR, IR, ESI, elemental analysis and single-crystal X-ray diffraction techniques. Investigation of intermolecular interaction via Hirshfeld surface analysis indicates that these close contacts are mainly ascribed to N[sbnd]H???N hydrogen bonding. Frontier molecular orbital and natural bond orbital (NBO) analysis shows that compound (I) and (II) possess a relatively higher kinetic stability. As a general type of catalyst, the reactive activity in the reaction of benzophenone-imine cyanosilylation was carried out to give a better performance with high yields of 80.0% and 86.0% for (I) and (II) respectively.

Multi-component synthesis of 6-alkoxy-2-amino-3,5-dicyanopyridines

An efficient one-pot synthesis of mono- and bis-6-alkoxy-2-amino-3,5- dicyanopyridines via a four or pseudoseven-component reaction of aldehyde, malononitrile and alcohol using K2CO3 as the base is described.

Medicine comprising dicyanopyridine derivative

Compounds having a high conductance-type of calcium-activated K channel opening effect and a smooth muscle relaxant effect for bladder based on the K-channel opening effect, which can be used in treating pollakiuria and urinary incontinence, are provided.