571176-82-4 Usage
Description
(2S,4R)-4-(Acetylthio)-2-[[(aMinosulfonyl)[(1,1-diMethylethoxy)carbonyl]aMino]Methyl]-1-pyrrolidinecarboxylic Acid (4-Nitrophenyl) Ethyl Ester is a complex organic compound with a unique chemical structure. It is characterized by its chiral centers at the 2nd and 4th positions, which give it a specific stereochemistry. (2S,4R)-4-(Acetylthio)-2-[[(aMinosulfonyl)[(1,1-diMethylethoxy)carbonyl]aMino]Methyl]-1-pyrrolidinecarboxylic Acid (4-Nitrophenyl) Ethyl Ester is an important intermediate in the synthesis of pharmaceuticals and other chemical products due to its versatile functional groups and reactivity.
Uses
1. Used in Pharmaceutical Industry:
(2S,4R)-4-(Acetylthio)-2-[[(aMinosulfonyl)[(1,1-diMethylethoxy)carbonyl]aMino]Methyl]-1-pyrrolidinecarboxylic Acid (4-Nitrophenyl) Ethyl Ester is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure and functional groups make it a valuable building block for the development of new drugs with potential therapeutic applications.
2. Used in Chemical Research:
(2S,4R)-4-(Acetylthio)-2-[[(aMinosulfonyl)[(1,1-diMethylethoxy)carbonyl]aMino]Methyl]-1-pyrrolidinecarboxylic Acid (4-Nitrophenyl) Ethyl Ester is also utilized in chemical research as a model system for studying various reaction mechanisms and exploring new synthetic routes. Its reactivity and structural features provide insights into the behavior of similar compounds and can lead to the discovery of novel chemical transformations.
3. Used in Material Science:
(2S,4R)-4-(Acetylthio)-2-[[(aMinosulfonyl)[(1,1-diMethylethoxy)carbonyl]aMino]Methyl]-1-pyrrolidinecarboxylic Acid (4-Nitrophenyl) Ethyl Ester can be employed in the development of new materials with specific properties. Its functional groups can be tailored to create materials with unique characteristics, such as improved stability, reactivity, or selectivity, which can be applied in various industries.
Check Digit Verification of cas no
The CAS Registry Mumber 571176-82-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,7,1,1,7 and 6 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 571176-82:
(8*5)+(7*7)+(6*1)+(5*1)+(4*7)+(3*6)+(2*8)+(1*2)=164
164 % 10 = 4
So 571176-82-4 is a valid CAS Registry Number.
571176-82-4Relevant articles and documents
Practical large-scale synthesis of the 2-aminomethylpyrrolidin-4-ylthio-containing side chain of the novel carbapenem antibiotic doripenem
Nishino, Yutaka,Komurasaki, Tadafumi,Yuasa, Tetsuya,Kakinuma, Makoto,Izumi, Kenji,Kobayashi, Makoto,Fujiie, Shinichiro,Gotoh, Teruhiro,Masui, Yoshiyuki,Hajima, Makoto,Takahira, Masayuki,Okuyama, Akira,Kataoka, Takahiro
, p. 649 - 654 (2003)
The first synthesis using an original procedure and a practical large-scale process using an improved procedure for the synthesis of the N-PNZ-protected 2-aminomethylpyrrolidin-4-ylthio-containing side chain of doripenem hydrate (S-4661), a novel parenteral 1β-methylcarbapenem antibiotic, are described, trans-4-Hydroxy-L-proline (4) was converted in an efficient process to (2S,4S)-4-acetylthio-2-(N-sulfamoyl-tert-butoxycarbonylaminomethyl) -1-(4-nitrobenzyloxycarbonyl)pyrrolidine (3) in 55-56% overall yield via a six-step sequence, which includes the two alternative routes to intermediate 13. This process requires no chromatographic purifications, no cryogenic temperatures, no haloalkane solvents, and short operating times and is amenable to a multikilogram-scale preparation. Several kilograms of the side chain 3 were successfully prepared by this process.
