5730-96-1

Basic information

• Product Name: 1-(2'-nitro[1,1'-biphenyl]-4-yl)ethan-1-one
• Synonyms: 1-(2'-nitro[1,1'-biphenyl]-4-yl)ethan-1-one;2-Nitro-4'-acetylbiphenyl;4-Acetyl-2'-nitro-1,1'-biphenyl;Einecs 227-235-3
• CAS NO: 5730-96-1
• Molecular Formula: C₁₄H₁₁NO₃
• Molecular Weight: 241.24204
• EINECS: 227-235-3
• Mol File: 5730-96-1.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 386.2°Cat760mmHg
• Flash Point: 181.6°C
• Appearance: /
• Density: 1.217g/cm³
• CAS DataBase Reference: 1-(2'-nitro[1,1'-biphenyl]-4-yl)ethan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2'-nitro[1,1'-biphenyl]-4-yl)ethan-1-one(5730-96-1)
• EPA Substance Registry System: 1-(2'-nitro[1,1'-biphenyl]-4-yl)ethan-1-one(5730-96-1)

Safety Data

• Hazardous Substances Data: 5730-96-1(Hazardous Substances Data)

Usage

General Description

1-(2'-nitro[1,1'-biphenyl]-4-yl)ethan-1-one, also known as 4'-nitroacetophenone, is a chemical compound with the molecular formula C14H11NO3. It is a yellow crystalline solid that is used in the synthesis of various organic compounds and pharmaceuticals. This chemical is an important intermediate in the production of dyes, pigments, and other organic substances. It is also used as a reagent in organic chemistry reactions, such as the synthesis of heterocyclic compounds. Additionally, 1-(2'-nitro[1,1'-biphenyl]-4-yl)ethan-1-one has been studied for its potential pharmacological properties and is known to exhibit some biological activity, making it a compound of interest for pharmaceutical research.

Upstream product

• 86-00-0 2-nitrobiphenyl 
• 75-36-5 acetyl chloride 
• 552-16-9 ortho-nitrobenzoic acid 
• 99-90-1 para-bromoacetophenone 
• 99-91-2 para-chloroacetophenone 
• 15163-59-4 potassium o-nitrobenzoate 
• 109613-00-5 4-acetophenyl triflate 
• 149104-90-5 4-acetylphenylboronic acid 
• 92-91-1 biphenyl-4-acetaldehyde 
• 577-19-5 2-nitrophenyl bromide 
• 190788-59-1 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nitrobenzene 
• 13329-40-3 4-Iodoacetophenone 
• 98-80-6 phenylboronic acid 
• 5570-19-4 2-nitrophenylboronic acid 

Downstream Products

• 5737-79-1 methyl 2′-amino-[1,1′-biphenyl]-4-carboxylate 
• 5730-77-8 methyl 2'-amino-[1,1'-biphenyl]-4-carboxylate 
• 23592-74-7 2-acetylcarbazole 

Relevant articles and documents

Visible-light-driven Cadogan reaction

Visible-light-driven photochemical Cadogan-type cyclization has been discovered. The organic D-A type photosensitizer 4CzIPN found to be an efficient mediator to transfer energy from photons to the transient intermediate that breaks the barriers of deoxygenation in Cadogan reaction and enables a mild metal-free access to carbazoles and related heterocycles. DFT calculation results indicate mildly endergonic formation of the intermediate complex of nitrobiarenes and PPh3, which corresponds with experimental findings regarding reaction temperature. The robust synthetic capacity of the photoredox Cadogan reaction systems has been demonstrated by the viable productivity of a broad range of carbazoles and related N-heterocycles with good tolerance of various functionalities.

A 4 - (1-substituted phenylvinyl) biphenyl derivative and its preparation method and application

The invention relates to 4-(1-substituted-phenylvinyl)biphenyl derivatives, and a preparation method and application thereof. The structural general formula of the 4-(1-substituted-phenylvinyl)biphenyl derivatives is disclosed in the specification. The 4-(1-substituted-phenylvinyl)biphenyl derivatives can be used for preparing microtubulin inhibitors, protein kinase inhibitors and medicines for treating various cancers responding against cytotoxic activity (such as mammary cancer or colon cancer) and abnormal angiogenesis related cancers, and has the characteristics of high efficiency, low toxicity and multiplex inhibitory effects.

Copper-catalyzed decarboxylation of aromatic carboxylic acids: En route to milder reaction conditions

The copper-catalyzed decarboxylation of carboxylic aromatic acids has been advantageously achieved by using aliphatic amines like tetramethylethylenediamine (TMEDA) or hexamethylenetetraamine (HMTA) as ligands instead of the aromatic heterocyclic amines (quinoline, phenanthroline) used until now. The improvement is significant since the reaction can be performed at a lower temperature (ca. 50 °C less) and the reaction time is clearly shorter (15 min instead of 12 to 24 h). Copyright