57427-77-7

Upstream product

• 495-69-2 Hippuric Acid 
• 104-88-1 4-chlorobenzaldehyde 
• 1199-01-5 2-phenylazlactone 
• 98-88-4 benzoyl chloride 
• 56-40-6 glycine 
• 14848-36-3 4-chloromethylene-2-phenyl-4H-oxazol-5-one 
• 108-90-7 chlorobenzene 

Downstream Products

• 82301-66-4 (Z)-N-benzoylamino-3-(4-chlorophenyl) acrylic acid methyl ester 
• 93634-57-2 2-benzoylamino-3-(4-chlorophenyl)acrylic acid 
• 344346-69-6 5-[1-(4-Chloro-phenyl)-meth-(Z)-ylidene]-2,3-diphenyl-3,5-dihydro-imidazol-4-one 
• 344346-72-1 3-Benzyl-5-[1-(4-chloro-phenyl)-meth-(Z)-ylidene]-2-phenyl-3,5-dihydro-imidazol-4-one 
• 33401-57-9 6-(4-Chloro-benzyl)-3-mercapto-2H-[1,2,4]triazin-5-one 
• 118779-02-5 6-(4-Chloro-benzyl)-3-methylsulfanyl-2H-[1,2,4]triazin-5-one 
• 57427-92-6 E-2-phenyl-4-(α-p-chlorophenylethylidene)-5-(4H)-oxazolone 
• 1022086-40-3 (Z)-2-benzamido-3-(4-chlorophenyl)acrylohydrazide 

Relevant academic research and scientific papers

Pharmaceutical composition and method of treating cancer

Cytotoxic compounds containing a phenyl core, amide link(s), an imidazolinone or a propenamide moiety. Also described are pharmaceutical compositions incorporating the cytotoxic compounds and methods for treating cancer. These compounds are cytotoxic against breast, prostate, and leukemia cancer cell lines via dual inhibition of Src kinases and tubulin.

An eco-compatible access to diversified bisoxazolone and bisimidazole derivatives

An efficient, straight-forward and eco-friendly synthetic strategy for the assembly of novel bisoxazolones via a four-component, sequential reaction of dialdehydes, glycine, benzoyl chloride and acetic anhydride, using ultrasound radiation, is described. Additionally, a diverse group of new bisimidazoles has been synthesized in good yields by the sonication of diamines and (Z)-4-Arylidene-2-phenyloxazol-5(4H)-ones. These approaches have resulted in a number of successful routes for the facile synthesis of bis-oxazolone and bis-imidazole frameworks within minutes of irradiation. Excellent outcomes using these environmentally-friendly parameters make these synthetic schemes ideal, sustainable, green-chemistry procedures and provide simple access towards the preparation of bisheterocycles. Formula parented.

Stereoselective Intermolecular [2 + 2] Cycloadditions of Erlenmeyer-Pl?chl Azlactones Using Visible Light Photoredox Catalysis

The first report of the preparation of symmetric and nonsymmetric diaminotruxinic derivatives through the photoredox [2 + 2] cycloadditions of Erlenmeyer azlactones is described, affording the desired compounds in high regio- and diastereocontrol (only head-to-head coupling). Mechanistic studies by DFT suggest that the reaction proceeds through a neutral photocatalytic pathway.

In vitro antitubercular, antibacterial and antifungal activities of 4- (3,4-disubstituted) benzylidene -2- phenyloxazolin-5-ones and their phenyl acrylohydrazides

Some new 2-benzamido-3-(3,4-substituted) phenylacrylohydrazides 3a-g were synthesized from 4-(3,4-substituted) benzylidene-2-phenyl oxazol-5(4H)-ones 2a-g and characterized by IR, 1H NMR, 13C NMR and mass spectral and elemental analy

An efficient and green synthesis of benzylidene-2-N-(carbothioamido)-6-oxo-1,2,5,6-tetrahydro-1-NH-1,2,4-triazine derivatives and their antibacterial activity evaluation

An efficient and green synthesis of (Z)-3-allkyl-5(benzylidene/substituted benzylidene)-2N-(carbothioamido)-6-oxo-1,2,5,6-tetrahydro-1-NH-1,2,4-triazine derivatives have been developed in good yields and tested for their antibacterial activities against Escherichia coli, Providencia aeruginosa, Pseudomonas azotogensis and Baccilus subtillis. Some of the synthesized compounds possess good activity against Escherichia coli and Baccilus subtillis compared to standard drug streptomycin.

In viro antitubercular, antibacterial and antifungal activities of 4- (3,4-disubstituted) benzylidene-2-phenyloxazolin-5-ones and their phenyl acrylohydrazides

Some new 2-benzamido -3-(3,4-substituted) phenylacrylohydrazides 3a-g were synthesized from 4-(3,4-substituted) benzylidene-2-phenyl oxazol-5-(4H)-ones 2a-g and characterized by IR, 1H NMR, 13C-NMR and mass spectral studies. Compound

Organic-inorganic hybrid polyoxometalates: Efficient, heterogeneous and reusable catalysts for solvent-free synthesis of azlactones

Two organic-inorganic hybrid polyoxometalates, consist of 1-butyl-3-methylimidazolium salts of (W10O32)4- and (PW12O40)3- polyanions were prepared and characterized by thermal analysis, X-ray diffraction, FT-IR, diffuse reflectance UV-Vis spectroscopic methods and nitrogen absorption-desorption determination (BET). These heterogeneous catalysts were used for synthesis of azlactones by the reaction of aldehydes with hippuric acid and acetic anhydride under solvent-free conditions. These catalysts were reused several times without loss of their activities.

Pseudo-peptides derived from isomannide: Inhibitors of serine proteases

In this paper, we describe the synthesis of a novel class of pseudo-peptides derived from isomannide and several oxazolones as potential inhibitors of serine proteases as well as preliminary pharmacological assays for hepatitis C. Hepatitis C, dengue and West Nile fever are among the most important flaviviruses that share one important serine protease enzyme. Serine proteases belong to the most studied class of proteolytic enzymes and are a primary target in the drug development field. Several pseudo-peptides were obtained in good yields from the reaction of isomannide and oxazolones, and their anti-HCV potential using the HCV replicon-based assay was shown.

Novel peptide mimetic inhibitors of hepatitis C serine protease derived from isomannide

Hepatitis C (HCV) infection is a cause of chronic liver disease such as cirrhosis, carcinoma, or liver failure, and the current therapy is effective in only 50% of patients. Serine proteases, which are present in HCV, are the most studied class of proteolytic enzymes, and are a primary target in the drug development field. In this paper, we describe the synthesis and biological studies of a novel class of peptide mimetic compounds as potential HCV serine protease inhibitors. Georg Thieme Verlag Stuttgart.

Preferential formation of cis-4,5-dihydrooxazole derivatives via photoinduced electron transfer-initiated cyclization of N-acyl-α-dehydroarylalanine alkyl esters

The alkyl, aryl, and acyl substituent effects on the photoinduced electron transfer-initiated cyclization reaction of the title compounds (1) were investigated in polar solvents from mechanistic and synthetic points of view. The irradiation of (Z)-1 in me