57427-88-0

Upstream product

• 495-69-2 Hippuric Acid 
• 104-87-0 4-methyl-benzaldehyde 
• 27115-50-0 N-(4-methylbenzoyl)glycine 
• 100-52-7 benzaldehyde 
• 123-11-5 4-methoxy-benzaldehyde 
• 31814-58-1 N-[(acetylamino)(4-methylphenyl)methyl]acetamide 
• 98-88-4 benzoyl chloride 
• 56-40-6 glycine 
• 108-24-7 acetic anhydride 

Downstream Products

• 97856-44-5 N-((Z)-1-hydroxymethyl-2-p-tolyl-vinyl)-benzamide 
• 69015-79-8 Z-2-phenyl-4-(α-p-methylphenylethylidene)-5(4H)-oxazolone 
• 39645-28-8 (1R,3S)-5-Phenyl-1-p-tolyl-6-oxa-4-aza-spiro[2.4]hept-4-en-7-one 
• 39645-28-8 (1S,3S)-5-Phenyl-1-p-tolyl-6-oxa-4-aza-spiro[2.4]hept-4-en-7-one 
• 140861-05-8 N-benzoyl-(R,S)-4-methylphenylalanine methyl ester 
• 72615-50-0 (Z)-N-benzoylamino-3-(4-methylphenyl) acrylic acid methyl ester 
• 134306-80-2 N-[(E)-1-(2-Mercapto-phenylcarbamoyl)-2-p-tolyl-vinyl]-benzamide 
• 95037-59-5 (5R,6R)-2-Phenyl-6-p-tolyl-9-(2,4,6-trimethyl-phenyl)-3,7-dioxa-1,8-diaza-spiro[4.4]nona-1,8-dien-4-one 
• 129624-51-7 (4R,5R)-1,3,7-Triphenyl-4-p-tolyl-8-oxa-1,2,6-triaza-spiro[4.4]nona-2,6-dien-9-one 
• 125748-42-7 (5R,9S)-2,6,8-Triphenyl-9-p-tolyl-3-oxa-1,7,8-triaza-spiro[4.4]nona-1,6-dien-4-one 
• 129193-16-4 (4S,5R)-4-Benzoylamino-1,3-diphenyl-5-p-tolyl-4,5-dihydro-1H-pyrazole-4-carboxylic acid 
• 15666-84-9 2-phenylperimidine 
• 129624-53-9 (4R,5R)-3-(4-Chloro-phenyl)-1,7-diphenyl-4-p-tolyl-8-oxa-1,2,6-triaza-spiro[4.4]nona-2,6-dien-9-one 
• 95037-64-2 (5R,6R)-9-(2,6-Dichloro-phenyl)-2-phenyl-6-p-tolyl-3,7-dioxa-1,8-diaza-spiro[4.4]nona-1,8-dien-4-one 

Relevant academic research and scientific papers

Design and development of 5-(4H)-oxazolones as potential inhibitors of human carbonic anhydrase VA: towards therapeutic management of diabetes and obesity

Inhibitors of carbonic anhydrase (CAIs) hold promise for addressing various diseases, including cancer, diabetes, and other metabolic syndromes. CAV is the only isoform present in the mitochondria and is considered a potential drug target for obesity. In

Synthesis of 2-substituted 4-arylidene-5(4h)-oxazolones as potential cytotoxic agents in the presence of lemon juice as a biocatalyst

Background: The oxazolone class of compounds is known to exert a profound effect on malignant cell proliferation, tumor angiogenesis and /or on the established neoplastic vasculature. Additionally, these compounds are generally known to have a low tendenc

Copper nitrate-mediated synthesis of 3-aryl isoxazolines and isoxazoles from olefinic azlactones

A copper nitrate-mediated [2 + 2 + 1] cycloaddition reaction was developed for the expedient synthesis of pharmacologically interesting 3-aryl substituted isoxazolines and isoxazoles through CC bond cleavage. Copper nitrate is employed as a reaction promoter and precursor of nitrile oxides. The given approach features a new mode of cycloaddition from olefinic azlactones, copper nitrate and unsaturated compounds with wide substrate scope, good functional group tolerance and operational simplicity.

Stereoselective Intermolecular [2 + 2] Cycloadditions of Erlenmeyer-Pl?chl Azlactones Using Visible Light Photoredox Catalysis

The first report of the preparation of symmetric and nonsymmetric diaminotruxinic derivatives through the photoredox [2 + 2] cycloadditions of Erlenmeyer azlactones is described, affording the desired compounds in high regio- and diastereocontrol (only head-to-head coupling). Mechanistic studies by DFT suggest that the reaction proceeds through a neutral photocatalytic pathway.

An eco-compatible access to diversified bisoxazolone and bisimidazole derivatives

An efficient, straight-forward and eco-friendly synthetic strategy for the assembly of novel bisoxazolones via a four-component, sequential reaction of dialdehydes, glycine, benzoyl chloride and acetic anhydride, using ultrasound radiation, is described. Additionally, a diverse group of new bisimidazoles has been synthesized in good yields by the sonication of diamines and (Z)-4-Arylidene-2-phenyloxazol-5(4H)-ones. These approaches have resulted in a number of successful routes for the facile synthesis of bis-oxazolone and bis-imidazole frameworks within minutes of irradiation. Excellent outcomes using these environmentally-friendly parameters make these synthetic schemes ideal, sustainable, green-chemistry procedures and provide simple access towards the preparation of bisheterocycles. Formula parented.

A convenient synthesis of 4-arylidene-2-phenyl-5(4H)-oxazolones under solvent-assisted grinding

A facile and effective approach for the synthesis of 4-arylidene-2-phenyl-5(4H)-oxazolones has been developed. Under solvent-assisted grinding in the presence of 2,4,6-trichloro-1,3,5-triazine, catalytic triphenylphosphine, and sodium carbonate, dehydrati

Catalytic aza-wittig reaction of acid anhydride for the synthesis of 4H-benzo[d][1,3]oxazin-4-ones and 4-benzylidene-2-aryloxazol-5(4H)-ones

Compared to the aza-Wittig reaction of aldehydes, ketones, amides, and esters, the aza-Wittig reaction of acid anhydride was always overlooked, which should be an important part of Wittig reactions. Here, the aza-Wittig reaction of anhydride and catalytic aza-Wittig reaction of anhydride were both developed with high yields, which provides an efficient method to synthesize of 4H-benzo[d][1,3]oxazin-4-ones and 4-benzylidene-2-aryloxazol-5(4H)-ones. The strategy of copper-catalyzed reduction of phosphine oxide was used and found effective for this transformation. Additionally, the one-pot catalytic aza-Wittig reaction of carboxylic acids was achieved. Furthermore, NMR experiments and Hammett plot recorded the process of catalytic aza-Wittig reaction of anhydride, which provides direct proof that the copper-catalyzed reduction of waste phosphine oxide is the key step in this transformation.

Oxazolone-based photoswitches: Synthesis and properties

The synthesis, photophysics and photochemistry of a family of molecular switches inspired by the green fluorescent protein (GFP) chromophore is presented. These compounds can be synthesized in one step and good yields, their photophysical properties may b

Practical synthesis of 4-benzylidene-2-phenyl-5(4H)-oxazolones

A simple and alternative method has been developed for the synthesis of 4-benzylidene-2-phenyl-5(4H)-oxazolones via reactions of hippuric acid with various aldehydes in the presence of 2-chloro-4,6-dimethoxy-1,3,5-triazine/N- methylmorpholine at 75 °C. Co

Synthesis and antibacterial activity of certain fused azoles and oxazinones

2-Phenyl-4-benzylidene-5(4H)-oxazolones (1a-e) were used as versatile starting materials for the synthesis of fused compounds such as: 4H-3,1-benoxazin-4-ones (2a,b), imidazo[4,3-b]benzimidazoles (3,4), imidazo[1,5-b]1,2,4-triazoles (5a,b), and 7.