57427-88-0

Basic information

• Product Name: (4E)-4-(4-methylbenzylidene)-2-phenyloxazol-5(4H)-one
• Synonyms: (4E)-4-(4-methylbenzylidene)-2-phenyloxazol-5(4H)-one
• CAS NO: 57427-88-0
• Molecular Weight: 263.296
• Mol File: 57427-88-0.mol
• Article Data: 19

Chemical Properties

• CAS DataBase Reference: (4E)-4-(4-methylbenzylidene)-2-phenyloxazol-5(4H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: (4E)-4-(4-methylbenzylidene)-2-phenyloxazol-5(4H)-one(57427-88-0)
• EPA Substance Registry System: (4E)-4-(4-methylbenzylidene)-2-phenyloxazol-5(4H)-one(57427-88-0)

Safety Data

• Hazardous Substances Data: 57427-88-0(Hazardous Substances Data)

Upstream product

• 27115-50-0 N-(4-methylbenzoyl)glycine 
• 100-52-7 benzaldehyde 
• 98-88-4 benzoyl chloride 
• 495-69-2 Hippuric Acid 
• 104-87-0 4-methyl-benzaldehyde 
• 56-40-6 glycine 
• 31814-58-1 N-[(acetylamino)(4-methylphenyl)methyl]acetamide 
• 123-11-5 4-methoxy-benzaldehyde 
• 108-24-7 acetic anhydride 

Downstream Products

• 69015-79-8 Z-2-phenyl-4-(α-p-methylphenylethylidene)-5(4H)-oxazolone 
• 39645-28-8 (1R,3S)-5-Phenyl-1-p-tolyl-6-oxa-4-aza-spiro[2.4]hept-4-en-7-one 
• 39645-28-8 (1S,3S)-5-Phenyl-1-p-tolyl-6-oxa-4-aza-spiro[2.4]hept-4-en-7-one 
• 140861-05-8 N-benzoyl-(R,S)-4-methylphenylalanine methyl ester 
• 72615-50-0 (Z)-N-benzoylamino-3-(4-methylphenyl) acrylic acid methyl ester 
• 134306-80-2 N-[(E)-1-(2-Mercapto-phenylcarbamoyl)-2-p-tolyl-vinyl]-benzamide 
• 95037-59-5 (5R,6R)-2-Phenyl-6-p-tolyl-9-(2,4,6-trimethyl-phenyl)-3,7-dioxa-1,8-diaza-spiro[4.4]nona-1,8-dien-4-one 
• 129624-51-7 (4R,5R)-1,3,7-Triphenyl-4-p-tolyl-8-oxa-1,2,6-triaza-spiro[4.4]nona-2,6-dien-9-one 
• 125748-42-7 (5R,9S)-2,6,8-Triphenyl-9-p-tolyl-3-oxa-1,7,8-triaza-spiro[4.4]nona-1,6-dien-4-one 
• 129193-16-4 (4S,5R)-4-Benzoylamino-1,3-diphenyl-5-p-tolyl-4,5-dihydro-1H-pyrazole-4-carboxylic acid 
• 15666-84-9 2-phenylperimidine 
• 129624-53-9 (4R,5R)-3-(4-Chloro-phenyl)-1,7-diphenyl-4-p-tolyl-8-oxa-1,2,6-triaza-spiro[4.4]nona-2,6-dien-9-one 
• 95037-64-2 (5R,6R)-9-(2,6-Dichloro-phenyl)-2-phenyl-6-p-tolyl-3,7-dioxa-1,8-diaza-spiro[4.4]nona-1,8-dien-4-one 
• 38335-22-7 2-oxo-3-(p-tolyl)propanoic acid 

Relevant articles and documents

Design and development of 5-(4H)-oxazolones as potential inhibitors of human carbonic anhydrase VA: towards therapeutic management of diabetes and obesity

Inhibitors of carbonic anhydrase (CAIs) hold promise for addressing various diseases, including cancer, diabetes, and other metabolic syndromes. CAV is the only isoform present in the mitochondria and is considered a potential drug target for obesity. In

Copper nitrate-mediated synthesis of 3-aryl isoxazolines and isoxazoles from olefinic azlactones

A copper nitrate-mediated [2 + 2 + 1] cycloaddition reaction was developed for the expedient synthesis of pharmacologically interesting 3-aryl substituted isoxazolines and isoxazoles through CC bond cleavage. Copper nitrate is employed as a reaction promoter and precursor of nitrile oxides. The given approach features a new mode of cycloaddition from olefinic azlactones, copper nitrate and unsaturated compounds with wide substrate scope, good functional group tolerance and operational simplicity.

An eco-compatible access to diversified bisoxazolone and bisimidazole derivatives

An efficient, straight-forward and eco-friendly synthetic strategy for the assembly of novel bisoxazolones via a four-component, sequential reaction of dialdehydes, glycine, benzoyl chloride and acetic anhydride, using ultrasound radiation, is described. Additionally, a diverse group of new bisimidazoles has been synthesized in good yields by the sonication of diamines and (Z)-4-Arylidene-2-phenyloxazol-5(4H)-ones. These approaches have resulted in a number of successful routes for the facile synthesis of bis-oxazolone and bis-imidazole frameworks within minutes of irradiation. Excellent outcomes using these environmentally-friendly parameters make these synthetic schemes ideal, sustainable, green-chemistry procedures and provide simple access towards the preparation of bisheterocycles. Formula parented.