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Usage

Uses

Used in Pharmaceutical Research:
(4E)-2-phenyl-4-(1-phenylethylidene)-1,3-oxazol-5(4H)-one is used as a research compound for its role in the development of pharmaceutical drugs. Its unique structure and properties allow for the exploration of its potential interactions with biological targets, which can lead to the discovery of new therapeutic agents.
Used in Drug Synthesis:
In the pharmaceutical industry, (4E)-2-phenyl-4-(1-phenylethylidene)-1,3-oxazol-5(4H)-one is used as a key building block for the synthesis of various biologically active compounds. Its incorporation into drug molecules can enhance their efficacy, selectivity, and pharmacokinetic properties, contributing to the advancement of novel therapeutics.
Used in Medicinal Chemistry:
(4E)-2-phenyl-4-(1-phenylethylidene)-1,3-oxazol-5(4H)-one is employed as a valuable tool in medicinal chemistry. Its molecular structure and functional groups offer potential for modulating biological activity, making it an important compound in the design and development of new drugs with improved therapeutic profiles.
Used in Drug Discovery:
Within the field of drug discovery, (4E)-2-phenyl-4-(1-phenylethylidene)-1,3-oxazol-5(4H)-one is used as a starting point for the design of new drug candidates. Its unique properties and reactivity enable researchers to create a diverse array of compounds with potential therapeutic applications, driving innovation in pharmaceutical development.

Upstream product

• 69015-75-4 (Z)-2-phenyl-4-(α-phenylethylidene)-5-(4H)-oxazolone 
• 495-69-2 Hippuric Acid 
• 98-86-2 acetophenone 
• 17606-70-1 (4Z)-4-benzylidene-2-phenyl-1,3-oxazol-5(4H)-one 
• 186581-53-3 diazomethane 
• 15732-43-1 (E)-2-phenyl-4-benzylidene-5(4H)-oxazolone 

Downstream Products

• 89141-17-3 (E)-N-benzoyl-β-methyldidehydrophenylalanine methyl ester 
• 77381-31-8 (E)-2-Benzoylamino-3-phenyl-but-2-enoic acid 
• 84405-01-6 N-((E)-1-Cyclohexylcarbamoyl-2-phenyl-propenyl)-benzamide 
• 84404-83-1 N-((E)-2-Phenyl-1-p-tolylcarbamoyl-propenyl)-benzamide 
• 77008-47-0 N-((E)-2-Phenyl-1-phenylcarbamoyl-propenyl)-benzamide 
• 95605-63-3 anilide of 1-phenyl-4-methyl-3-isoquinolincarboxylic acid 
• 95605-64-4 (Z)-2,3-diphenyl-5-(α-phenylethylidene)-4(5H)-imidazolone 
• 95605-62-2 N-((Z)-2-Phenyl-1-phenylcarbamoyl-propenyl)-benzamide 
• 675608-52-3 methyl (2S,3S)-2-benzamide-3-phenylbutanoate 
• 675608-51-2 methyl (2R,3R)-2-benzamide-3-phenylbutanoate 
• 59850-51-0 erythro-β-methylphenylalanine hydrochloride 
• 25488-26-0 erythro-D-(2R,3R)-β-methylphenylalanine 
• 25488-25-9 (2S,3S)-methylphenylalanine 
• 84404-95-5 N-((E)-1-Benzylcarbamoyl-2-phenyl-propenyl)-benzamide 

Relevant academic research and scientific papers

An efficient and stereodivergent synthesis of threo- and erythro-β-methylphenylalanine. Resolution of each racemic pair by semipreparative HPLC

threo and erythro diastereoisomers of the constrained amino acid (βMe)Phe can be obtained separately on a multigram scale through a three-step synthesis from the corresponding Z and E isomers of 2-phenyl-4(α-phenylethylidene)-5(4H)-oxazolone. The 5(4H)-ox

On the Synthesis of Geometric Isomers of 2-Methyl (or Phenyl)-4--5(4H)-oxazolones

Several Z-2-methyl(or phenyl)-4--5(4H)-oxazolones 3Z, 4Z were prepared.The results obtained were compared by diazomethane insertion and condensation procedure.In order to synthetize E-2-phenyl-4--5-(4H)-oxazolones 4E hy

ON THE SYNTHESIS OF UNSATURATED 4(5H)-IMIDAZOLONES

(Z)-2,3-Diphenyl-5-benzylidene-4(5H)-imidazolone and (Z)-2,3-diphenyl-5-(α-phenylethylidene)-4(5H)-imidazolone were obtained from the corresponding (Z)-2-phenyl-4-benzylidene-5(4H)-oxazolone and (Z)-2-phenyl-4-(α-phenylethylidene)-5(4H)-oxazolone and anil

Reaction of 4-Methylene-5(4H)-oxazolones With Diazomethane

The reaction of diazomethane with some (E) and (Z)-2-substituted-4-methylene-5(4)-oxazolones (1a-c) under two different conditions, has been studied. (E) and (Z)-1,2-disubstituted-7-oxo-6-oxa-4-azaspiro-hept-4-enes (3a-c, 4a-c) were mainly obtained, together with multiple addition compounds.The reaction showed to be stereoselective only when the substituents were aromatic.Acid hydrolysis of compounds 3a and 4a produced a mixture of (E) and (Z)-3,5-disubstituted-tetrahydrofuran-2-ones (8a, 9a).Smooth methanolysis of the ring led to (E) and (Z)-1-benzamido-cyclopropanecarboxylic esters (10a-c, 11a-c), which, on acid hydrolysis, gave (E) and (Z)-1-amino-2-phenylcyclopropanecarboxylic acids 12a and 13a.The pmr spectra have been analyzed by an iterative computer method, and the computed best values obtained have been used to deduce the stereochemistry of the spiroderivatives.