57826-37-6

Basic information

• Product Name: 1-benzoyl-3-methyl-1H-indole
• Synonyms: 1-benzoyl-3-methyl-1H-indole
• CAS NO: 57826-37-6
• Molecular Formula: C₁₆H₁₃NO
• Molecular Weight: 235
• Mol File: 57826-37-6.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-benzoyl-3-methyl-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzoyl-3-methyl-1H-indole(57826-37-6)
• EPA Substance Registry System: 1-benzoyl-3-methyl-1H-indole(57826-37-6)

Safety Data

• Hazardous Substances Data: 57826-37-6(Hazardous Substances Data)

Upstream product

• 52562-19-3 2-isopropenylaniline 
• 551-93-9 2-aminoacetophenone 
• 1885-29-6 anthranilic acid nitrile 
• 106012-41-3 N-[2-(1-methylethenyl)phenyl]benzamide 
• 130013-23-9 2-iodo-N-allyl-N-benzoylaniline 
• 22397-26-8 N-benzoyl-2-hydroxy-3-methylindoline 
• 83-34-1 3-Methylindole 
• 98-88-4 benzoyl chloride 
• 1400666-14-9 N-cyclohexene-1-carbonyl-3-methylindole 
• 6011-26-3 2'-acetylbenzanilide 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 74266-80-1 {2-[(2E)-1-methylbut-2-en-1-yl]phenyl}amine 

Downstream Products

• 1403485-84-6 (3-methyl-2-(1-phenylethyl)-1H-indol-1-yl)(phenyl)methanone 
• 1403485-87-9 (3-methyl-2-phenethyl-1H-indol-1-yl)(phenyl)methanone 
• 75424-71-4 exo-1-acetoxy-3-benzoyl-7b-methyl-1,2,2a,7b-tetrahydro-3H-cydclobutindole 
• 90539-96-1 exo-1-acetyl-3-benzoyl-7b-methyl-1,2,2a,7b-tetrahydro-3H-cyclobutindole 
• 87-52-5 3-(Dimethylaminomethyl)indole 

Relevant articles and documents

Copper-Catalyzed Sequential C(sp2)/C(sp3)?H Amination of 2-Vinylanilines with N-Fluorobenzenesulfonimide

An oxidative C?H diamination of 2-vinylanilines with N-fluorobenzenesulfonimide (NFSI) was developed for the efficient synthesis of indole frameworks. The reaction proceeded via sequential intra-/intermolecular diamination of C(sp2)?H and C(sp3)?H bond, incorporating one nitrogen from the substrate and the other nitrogen from the NFSI. (Figure presented.).

Regioselective hydroarylation reactions of C3 electrophilic N-acetylindoles activated by FeCl3: An entry to 3-(Hetero)arylindolines

A method for the direct and rare umpolung of the 3 position of indoles is reported. The activation of N-acetylindole with iron(III) chloride allows the C-H addition of aromatic and heteroaromatic substrates to the C2-C3 double bond of the indole nucleus to generate a quaternary center at C3 and leads regioselectively to 3-arylindolines. Optimization, scope (50 examples), practicability (gram scale, air atmosphere, room temperature), and mechanistic insights of this process are presented. Synthetic transformations of the indoline products into drug-like compounds are also described.

Ir(I)-catalyzed C-H bond alkylation of C2-position of indole with alkenes: Selective synthesis of linear or branched 2-alkylindoles

A cationic iridium-catalyzed C2-alkylation of N-substituted indole derivatives with various alkenes has been developed, which selectively gives linear or branched 2-alkylindoles in high to excellent selectivity. This protocol relies on the use of the carbonyl group on the nitrogen atom of indole as a directing group: a linear product was predominant when an acetyl group was used as a directing group, and a branched product was predominant with a benzoyl group.