583-19-7

Usage

Uses

Used in Pharmaceutical Industry:
2-Bromophenetole is used as a chemical intermediate for the synthesis of various complex molecules, contributing to the development of new drugs and pharmaceutical products. Its role in the synthesis process is crucial, as it can be transformed into a wide range of compounds with potential therapeutic applications.
Used in Chemical Industry:
2-Bromophenetole is used as a building block in the production of other organic compounds, which can be further utilized in various chemical processes and applications. Its versatility as a starting material makes it a valuable component in the synthesis of a diverse array of chemical products.

InChI:InChI=1/C8H9BrO/c1-2-10-8-6-4-3-5-7(8)9/h3-6H,2H2,1H3

Upstream product

• 74-96-4 ethyl bromide 
• 95-56-7 2-hydroxybromobenzene 
• 64-17-5 ethanol 
• 101251-12-1 3-bromo-4-ethoxyaniline 
• 103-73-1 Phenetole 
• 64-67-5 diethyl sulfate 
• 62-44-2 4-ethoxyacetanilide 
• 119532-30-8 acetic acid-(4-ethoxy-3-bromo-anilide) 
• 597-35-3 diethylsulfone 
• 584-08-7 potassium carbonate 
• 75-03-6 ethyl iodide 
• 698-00-0 2-bromo-N,N-dimethylaniline 
• 917-58-8 potassium ethoxide 

Downstream Products

• 58244-42-1 2-bromo-1-ethoxy-4-nitrobenzene 
• 157731-20-9 tris(2-ethoxyphenyl)bismuthane 
• 92863-20-2 1-(2-Ethoxyphenyl)-cyclohexen 
• 127154-52-3 (2-ethoxyphenyl)(phenyl)methanone 
• 95-56-7 2-hydroxybromobenzene 
• 202208-69-3 2'-ethoxy-biphenyl-4-carboxylic acid 
• 905590-14-9 4-(4-ethoxy-3-bromo-phenyl)-4-oxo-butyric acid 
• 209624-97-5 4-(2-bromoethyloxy)-benzoylformic acid 
• 1193444-20-0 tert-butyl (2-ethoxyphenyl)(oxo)acetate 
• 1207825-77-1 tris(o-ethoxyphenyl)chlorogermane 
• 1207825-79-3 tris(o-ethoxyphenyl)germane 
• 32306-86-8 tetrakis(o-ethoxyphenyl)germane 
• 1093065-10-1 1-bromo-2-ethoxybenzene-5-sulfonyl chloride 
• 41842-29-9 2-ethoxyphenylmagnesium bromide 

Relevant academic research and scientific papers

From Anilines to Aryl Ethers: A Facile, Efficient, and Versatile Synthetic Method Employing Mild Conditions

We have developed a simple and direct method for the synthesis of aryl ethers by reacting alcohols/phenols (ROH) with aryl ammonium salts (ArNMe3+), which are readily prepared from anilines (ArNR′2, R′=H or Me). This reaction proceeds smoothly and rapidly (within a few hours) at room temperature in the presence of a commercially available base, such as KOtBu or KHMDS, and has a broad substrate scope with respect to both ROH and ArNR′2. It is scalable and compatible with a wide range of functional groups.

ACC INHIBITORS AND USES THEREOF

The present invention provides compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.

PROCESS FOR THE PREPARATION OF 4-BROMOPHENYL DERIVATIVES

Disclosed is a process for the preparation of a mixture of 4-bromophenyl derivatives (compound of formula (2)) and 2,4-dibromophenyl derivatives (compound of formula (3)) comprising the steps of [1] reacting in a two-phase (liquid-liquid) system a bromide containing source with a phenyl derivative (formula (1)) in the presence of an excess of an oxidizing agent, an acid, and optionally a catalyst selected from vanadium pentoxide and ammonium heptamolybdate forming 4-bromo- (compound of formula (2)) and 2,4-dibromo derivatives (compound of formula (3)) and as intermediate product the 2-bromo derivative (compound of formula (4)) which reacts in step [2] to the 2,4-dibromo derivative (formula (3)) according to the following reaction scheme 2 wherein R1 is hydroxy; C1-C5alkoxy; or -NR2R3; and R2 and R3 independently from each other are hydrogen; or C1-C5alkyl.

INTERMEDIATES FOR PREPARATION OF AN INHIBITOR OF PHOSPHODIESTERASE TYPE 5

Boronic compounds of formula II and the process for their preparation, wherein Y1 and Y2 are selected from hydroxyl, (C1-C4)alcoxyl and phenoxyl optionally substituted with one or two radicals independently selected from (C1-C4)alkyl and (C1-C4)alcoxyl; or alternatively Y1 and Y2 together with the boron atom can form a cyclic system. Process for the preparation of Sildenafil by reaction of a intermediate of formula II with a intermediate of formula III, wherein X3 is a leaving group and R1 is selected from H and (C1-C4)alkyl.

Solvent-free Williamson synthesis: An efficient, simple, and convenient method for chemoselective etherification of phenols and bisphenols

Etherification of phenols with dimethyl- and diethylsulfates and benzyl chloride was performed efficiently in the presence of a suitable solid base, NaHCO3 or K2CO3, under solvent-free conditions. The reaction proceeded rapidly at low temperature, and the corresponding ethers were obtained with high purity and excellent yield. Selective etherification of electron-poor phenols in the presence of electron-rich ones and also selective mono-etherification of bisphenols are the noteworthy advantages of this method. This method is environmentally friendly. Copyright Taylor & Francis Group, LLC.

Induced bromination of aromatic hydrocarbons with alkali metal bromides in the presence of oxidants

The features of induced bromination of aromatic hydrocarbons in the NaBr(KBr)-HX-H2O2(NaOCl) system were studied. Pleiades Publishing, Inc., 2006.

Induced bromination of aromatic hydrocarbons by alkali metals bromides and sodium hypochlorite

Induced bromination of aromatic compounds in a system MBr-acid-NaOCl was studied. Optimum conditions of the process were developed, kinetics of the reactions were investigated, and the process mechanism was suggested. The bromination occurs both with the bromine in statu nascendi and with the hypobromous acid by hydrogen substitution exclusively in the aromatic ring. 2005 Pleiades Publishing, Inc.

Phenylsulfonyl-1,3-dihydro-2h-indole-2-one derivatives, their preparation and their therapeutic use

The invention relates to compounds of formula: and also to the salts thereof with mineral or organic acids, and the solvates and/or hydrates thereof, with affinity for and selectivity towards the arginine-vasopressin V1b receptors and/or for the ocytocin receptors and, furthermore, for certain compounds, affinity for the V1a receptors. The invention also relates to the process for preparing them, to the intermediate compounds of formula (IV) that are useful for preparing them, to pharmaceutical compositions containing them and to their use for preparing medicinal products.

Anilide derivative, production and use thereof

This invention is to provide a compound of the formula: wherein R1is an optionally substituted 5- to 6-membered ring; the ring A is an optionally substituted 6- to 7-membered ring; the ring B is an optionally substituted benzene ring; n is an integer of 1 or 2; Z is a chemical bond or a divalent group; R2is (1) an optionally substituted amino group in which a nitrogen atom may form a quaternary ammonium, (2) an optionally substituted nitrogen-containing heterocyclic ring group which may contain a sulfur atom or an oxygen atom as ring constituting atoms and wherein a nitrogen atom may form a quaternary ammonium, (3) a group binding through a sulfur atom or (4) a group of the formula: ?wherein k is 0 or 1, and when k is 0, a phosphorus atom may form a phosphonium; and R5and R6are independently an optionally substituted hydrocarbon group, an optionally substituted hydroxy group or an optionally substituted amino group, and R5and R6may bind to each other to form a cyclic group together with the adjacent phosphorus atom, or a salt thereof , which is useful for antagonizing CCR5 and also for the prevention and treatment of infectious disease of HIV.

HIV protease inhibitors useful for the treatment of AIDS

Compounds such as STR1 or pharmaceutically acceptable salts thereof, are HIV protease inhibitors. These compounds are useful in the prevention or treatment of infection by HIV and in the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.