58472-45-0

Basic information

• Product Name: 2-Propen-1-one, 1-(4-fluorophenyl)-2-methyl-
• Synonyms: 1-methacryloyl-4-fluorobenzene;4'-fluoro-2-methyl-acrylophenone;4'-Fluor-2-methylacrylophenon
• CAS NO: 58472-45-0
• Molecular Formula: C10H9FO
• Molecular Weight: 164.179
• Mol File: 58472-45-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 40-42 °C(Press: 0.1 Torr)
• Density: 1.072±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2-Propen-1-one, 1-(4-fluorophenyl)-2-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propen-1-one, 1-(4-fluorophenyl)-2-methyl-(58472-45-0)
• EPA Substance Registry System: 2-Propen-1-one, 1-(4-fluorophenyl)-2-methyl-(58472-45-0)

Safety Data

• Hazardous Substances Data: 58472-45-0(Hazardous Substances Data)

Upstream product

• 456-03-1 1-(4-fluorophenyl)propan-1-one 
• 127-19-5 N,N-dimethyl acetamide 
• 124-38-9 carbon dioxide 
• 403-43-0 4-fluorobenzoyl chloride 
• 557-93-7 2-bromoprop-1-ene 
• 116332-54-8 4-fluoro-N-methoxy-N-methylbenzamide 

Downstream Products

• 92771-58-9 5-(4-Fluoro-phenyl)-2,6-dimethyl-6,7-dihydro-[1,3,4]oxadiazepine 
• 41201-58-5 5-Fluoro-2-Methyl-Indan-1-One 

Relevant articles and documents

Br?nsted Base-Catalyzed Transformation of α,β-Epoxyketones Utilizing [1,2]-Phospha-Brook Rearrangement for the Synthesis of Allylic Alcohols Having a Tetrasubstituted Alkene Moiety

A stereoselective transformation of α,β-epoxyketones into alkenylphosphates having a hydroxymethyl group on the β-carbon was established by utilizing the [1,2]-phospha-Brook rearrangement under Br?nsted base catalysis. The reaction involves the catalytic generation of an α-oxygenated carbanion located at the α-position of an epoxide moiety through the [1,2]-phospha-Brook rearrangement and the following epoxide opening. Further transformation of the alkenylphosphates by the palladium-catalyzed cross-coupling reaction with Grignard reagents provided allylic alcohols having a stereodefined all-carbon tetrasubstituted alkene moiety.

Transition-Metal-Free Reductive Deoxygenative Olefination with CO2

A new transition-metal-free reductive deoxygenative olefination of phosphorus ylides with CO2, an abundant and sustainable C1 chemical feedstock, is described. This catalytic CO2 fixation afforded β-unsubstituted acrylates and vinyl ketones in good yields with broad scope and good functional group tolerance under mild reaction conditions. Cost-effective and easily handled polymethylhydrosiloxane was used as a reductant. Bis(silyl)acetal was proved to be the key intermediate in this reductive functionalization of CO2.

Iron-catalyzed α-methylenation of ketones with N,N-Dimethylacetamide: An approach for α,β-unsaturated carbonyl compounds

In this study, we developed a general iron-catalyzed α-methylenation of ketones by using N,N-dimethylacetamide as the one-carbon source. Various ketones, including aryl and alkyl ketones, enones, and dicarbonyl compounds were well tolerated to yield the corresponding α,β-unsaturated carbonyl compounds in the presence of an iron catalyst, peroxides, and N,N-dimethylacetamide under aerobic conditions. A general and facile iron-catalyzed α-methylenation of carbonyl compounds by using N-methyl amides as the one-carbon source was developed. Various carbonyl compounds (aryl- or alkyl-substituted, enones, 1,3-dicarbonyl compounds) were well tolerated to furnish the corresponding α,β-unsaturated carbonyl compounds in the presence of an iron catalyst, peroxides, and N-methyl amides under aerobic conditions.