586396-26-1

Basic information

• Product Name: 1,2,4-Pyrrolidinetricarboxylic acid, 2-methyl 1-(phenylmethyl) ester, (2S,4S)-
• CAS NO: 586396-26-1
• Molecular Formula: C15H17NO6
• Molecular Weight: 307.303
• Mol File: 586396-26-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1,2,4-Pyrrolidinetricarboxylic acid, 2-methyl 1-(phenylmethyl) ester, (2S,4S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,4-Pyrrolidinetricarboxylic acid, 2-methyl 1-(phenylmethyl) ester, (2S,4S)-(586396-26-1)
• EPA Substance Registry System: 1,2,4-Pyrrolidinetricarboxylic acid, 2-methyl 1-(phenylmethyl) ester, (2S,4S)-(586396-26-1)

Safety Data

• Hazardous Substances Data: 586396-26-1(Hazardous Substances Data)

Upstream product

• 130830-65-8 N-(benzyloxycarbonyl)-cis-4-cyano-L-proline ethyl ester 
• 130830-60-3 1-benzyl 2-ethyl(2S,4R)-4-[[(4-methylbenzene)sulfonyl]oxy]pyrrolidine-1,2-dicarboxylate 
• 103667-57-8 (2S,4R)-ethyl N¹-(benzyloxycarbonyl)-4-hydroxypyrrolidine-2-carboxylate 
• 33996-30-4 trans-4-hydroxy-L-proline ethyl ester hydrochloride 
• 51-35-4 4R-4-hydroxyproline 
• 130830-69-2 N-(benzyloxycarbonyl)-cis-4-carboxy-L-proline dimethyl ester 

Downstream Products

• 934005-42-2 4-(2-phenyl-cyclopropylcarbamoyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester 
• 1430105-81-9 C₁₅H₁₉NO₅ 
• 1446655-22-6 C₂₁H₂₃NO₄ 
• 1446655-24-8 C₂₈H₂₉NO₄ 
• 1446653-56-0 (2S,4S)-4-(benzyloxymethyl)-1-(2,2-diphenylacetyl)pyrrolidine-2-carboxylic acid 
• 1446655-28-2 C₂₃H₂₂N₂O₅ 
• 1446655-30-6 C₁₅H₁₆N₂O₃ 
• 1446655-32-8 C₂₉H₂₆N₂O₄ 
• 1446653-58-2 (2S,4S)-1-(2,2-diphenylacetyl)-4-(5-phenyloxazol-2-yl)pyrrolidine-2-carboxylic acid 
• 1446655-40-8 C₂₂H₂₅NO₆S 
• 1446655-34-0 C₂₉H₃₁NO₃S 
• 1446655-38-4 C₂₈H₂₉NO₃S 
• 1446653-64-0 C₂₇H₂₇NO₃S 
• 1446655-42-0 C₂₇H₂₇NO₃S 

Relevant articles and documents

Proline-glutamate chimeras in isopeptides. Synthesis and biological evaluation of conformationally restricted glutathione analogues

The two novel diastereoisomeric glutathione analogues 1 and 2 have been designed and synthesized by replacing the native γ-glutamylic moiety with the conformational rigid skeleton of cis- or trans-4-carboxy-L-proline residue. Both analogues have been obtained by following the solution phase peptide chemistry methodologies and final reduction of the corresponding disulfide forms 13 and 14. The two analogues 1 and 2 have been tested towards γ-glutamyltranspeptidase (γ-GT) and human glutathione S-transferase (hGST P1-1). Both analogues 1 and 2 are completely resistant to enzymatic degradation by γ-GT. The S-transferase utilizes the analogue 2 as a good substrate while is unable to bind the analogue 1.

Pyrrolidine compounds

A compound of the following formula: wherein R1, R2, R3, R4, R5, R6, R7, R8, T, X, Y, and Z are as defined herein. Also disclosed is a method for inhibiting dipeptidyl