586396-26-1

Basic information

• Product Name: 1,2,4-Pyrrolidinetricarboxylic acid, 2-methyl 1-(phenylmethyl) ester, (2S,4S)-
• CAS NO: 586396-26-1
• Molecular Formula: C15H17NO6
• Molecular Weight: 307.303
• Mol File: 586396-26-1.mol

Chemical Properties

• CAS DataBase Reference: 1,2,4-Pyrrolidinetricarboxylic acid, 2-methyl 1-(phenylmethyl) ester, (2S,4S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,4-Pyrrolidinetricarboxylic acid, 2-methyl 1-(phenylmethyl) ester, (2S,4S)-(586396-26-1)
• EPA Substance Registry System: 1,2,4-Pyrrolidinetricarboxylic acid, 2-methyl 1-(phenylmethyl) ester, (2S,4S)-(586396-26-1)

Safety Data

• Hazardous Substances Data: 586396-26-1(Hazardous Substances Data)

Upstream product

• 130830-65-8 N-(benzyloxycarbonyl)-cis-4-cyano-L-proline ethyl ester 
• 130830-60-3 1-benzyl 2-ethyl(2S,4R)-4-[[(4-methylbenzene)sulfonyl]oxy]pyrrolidine-1,2-dicarboxylate 
• 103667-57-8 (2S,4R)-ethyl N¹-(benzyloxycarbonyl)-4-hydroxypyrrolidine-2-carboxylate 
• 33996-30-4 trans-4-hydroxy-L-proline ethyl ester hydrochloride 
• 51-35-4 4R-4-hydroxyproline 
• 130830-69-2 N-(benzyloxycarbonyl)-cis-4-carboxy-L-proline dimethyl ester 

Downstream Products

• 1430105-81-9 C₁₅H₁₉NO₅ 
• 1446655-22-6 C₂₁H₂₃NO₄ 
• 1446655-24-8 C₂₈H₂₉NO₄ 
• 1446653-56-0 (2S,4S)-4-(benzyloxymethyl)-1-(2,2-diphenylacetyl)pyrrolidine-2-carboxylic acid 
• 1446655-28-2 C₂₃H₂₂N₂O₅ 
• 1446655-30-6 C₁₅H₁₆N₂O₃ 
• 1446655-32-8 C₂₉H₂₆N₂O₄ 
• 1446653-58-2 (2S,4S)-1-(2,2-diphenylacetyl)-4-(5-phenyloxazol-2-yl)pyrrolidine-2-carboxylic acid 
• 1446655-40-8 C₂₂H₂₅NO₆S 
• 1446655-34-0 C₂₉H₃₁NO₃S 
• 1446655-38-4 C₂₈H₂₉NO₃S 
• 1446653-64-0 C₂₇H₂₇NO₃S 
• 1446655-42-0 C₂₇H₂₇NO₃S 
• 1446653-66-2 (2S,4S)-1-(2,2-diphenylacetyl)-4-((phenylthio)methyl)pyrrolidine-2-carboxylic acid 

Relevant articles and documents

Proline-glutamate chimeras in isopeptides. Synthesis and biological evaluation of conformationally restricted glutathione analogues

The two novel diastereoisomeric glutathione analogues 1 and 2 have been designed and synthesized by replacing the native γ-glutamylic moiety with the conformational rigid skeleton of cis- or trans-4-carboxy-L-proline residue. Both analogues have been obtained by following the solution phase peptide chemistry methodologies and final reduction of the corresponding disulfide forms 13 and 14. The two analogues 1 and 2 have been tested towards γ-glutamyltranspeptidase (γ-GT) and human glutathione S-transferase (hGST P1-1). Both analogues 1 and 2 are completely resistant to enzymatic degradation by γ-GT. The S-transferase utilizes the analogue 2 as a good substrate while is unable to bind the analogue 1.

HETEROCYCLIC COMPOUNDS AND METHODS FOR THEIR USE

The present invention relates to heterocyclic compounds useful for antagonising angiotensin II Type 2 (AT2) receptor. More particularly the invention relates to pyrrolidine and azetidine compounds, compositions containing them and their use in methods of treating or preventing disorders or diseases associated with AT2 receptor function including neuropathic pain, inflammatory pain, conditions associated with neuronal hypersensitivity, impaired nerve conduction velocity, cell proliferation disorders, disorders associated with an imbalance between bone resorption and bone formation and disorders associated with aberrant nerve regeneration.

Pyrrolidine compounds

A compound of the following formula: wherein R1, R2, R3, R4, R5, R6, R7, R8, T, X, Y, and Z are as defined herein. Also disclosed is a method for inhibiting dipeptidyl