58699-61-9 Usage
General Description
2'-Azido-d-adenosine is a chemical compound consisting of an adenosine molecule with an azido group attached at the 2' position. It is a modified form of the natural nucleoside adenosine, and it is commonly used in chemical biology and biochemistry research. The azido group makes the compound reactive and is often used in studies of nucleic acid structure and function, as well as in labeling and tagging experiments to track and study the behavior of adenosine and related molecules. 2'-Azido-d-adenosine has also been investigated for its potential therapeutic applications, particularly in the development of antiviral drugs and cancer treatments. Due to its unique properties, this compound has shown promise in both research and potential medical uses.
Check Digit Verification of cas no
The CAS Registry Mumber 58699-61-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,8,6,9 and 9 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 58699-61:
(7*5)+(6*8)+(5*6)+(4*9)+(3*9)+(2*6)+(1*1)=189
189 % 10 = 9
So 58699-61-9 is a valid CAS Registry Number.
InChI:InChI=1/C10H13N8O3/c11-8-6-9(14-2-13-8)18(3-15-6)10-5(16-17-12)7(20)4(1-19)21-10/h2-5,7,10,12,19-20H,1H2,(H2,11,13,14)/q+1
58699-61-9Relevant articles and documents
Synthesis of non-hydrolyzable substrate analogs for Asp-tRNAAsn/Glu-tRNAGln amidotransferase
Klinchan, Chayada,Hsu, Yu-Ling,Lo, Lee-Chiang,Pluempanupat, Wanchai,Chuawong, Pitak
, p. 6204 - 6207 (2014/12/10)
Non-hydrolyzable substrate analogs for tRNA-dependent amidotransferase, 2′- or 3′-aspartyl or -glutamyl adenosine, were synthesized from adenosine without protection of the adenine base. The hydroxyl groups of adenosine were selectively protected, followed by a series of oxidation/reductions to alter the stereochemistry. DFT calculations revealed the driving forces for the ketone hydrate formation at C-2′, but not the C-3′ carbon during the oxidation step. Subsequently, triflation and azide replacement yielded azidoadenosines, which were coupled to protected amino acids after deprotection and reduction. After global deprotection, the target substrate analogs were obtained in 2-14% overall yields from adenosine.
Synthesis of 2'-substituted derivatives of neplanocin A (nucleosides and nucleotides. XLIV)
Fukukawa,Uedao,Hirano
, p. 1582 - 1592 (2007/10/02)
-
Studies of nucleosides and nucleotides. LXXX. Purine cyclonucleosides. (38). Synthesis of 6-substituted purine 2'-azido- and 2'-amino-2'-deoxyribofuranosides
Ikehara,Takatsuka
, p. 985 - 988,987, 988 (2007/10/08)
-
