58758-09-1

Basic information

• Product Name: 1H-Benzimidazole, 2-[(1E)-2-phenylethenyl]-
• CAS NO: 58758-09-1
• Molecular Formula: C15H12N2
• Molecular Weight: 220.274
• Mol File: 58758-09-1.mol
• Article Data: 31

Chemical Properties

• CAS DataBase Reference: 1H-Benzimidazole, 2-[(1E)-2-phenylethenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Benzimidazole, 2-[(1E)-2-phenylethenyl]-(58758-09-1)
• EPA Substance Registry System: 1H-Benzimidazole, 2-[(1E)-2-phenylethenyl]-(58758-09-1)

Safety Data

• Hazardous Substances Data: 58758-09-1(Hazardous Substances Data)

Upstream product

• 615-15-6 2-Methyl-1H-benzimidazole 
• 100-52-7 benzaldehyde 
• 140-10-3 (E)-3-phenylacrylic acid 
• 615-28-1 o-phenylenediamine dihydrochloride 
• 104-55-2 3-phenyl-propenal 
• 95-54-5 1,2-diamino-benzene 
• 74710-09-1 o-phenylenediamine sulphate 
• 14371-10-9 (E)-3-phenylpropenal 
• 28144-70-9 anthranilic acid amide 
• 175531-13-2 2-bromomethyl-1-tert-butoxycarbonylbenzimidazole 
• 89812-50-0 (E)-1,1-bis(methylthio)-5-phenylpenta-1,4-dien-3-one 
• 4392-24-9 Cinnamyl bromide 
• 130964-01-1 N¹-cinnamylbenzene-1,2-diamine 
• 59066-63-6 (E)-1-methyl-2-styryl-1H-benzo[d]imidazole 

Downstream Products

• 2849-93-6 2-benzimidazolecarboxylic acid 
• 56547-44-5 N-vinyl-2-styrylbenzimidazole 
• 1307837-03-1 (E)-1,3-diallyl-2-styryl-3H-benzo[d]imidazol-1-ium bromide 
• 59066-63-6 (E)-1-methyl-2-styryl-1H-benzo[d]imidazole 
• 1849-01-0 1-methyl-2-benzimidazolone 

Relevant articles and documents

Additive- and Oxidant-Free Expedient Synthesis of Benzimidazoles Catalyzed by Cobalt Nanocomposites on N-Doped Carbon

A one-pot direct synthesis of a wide range of biologically active benzimidazoles through coupling of phenylenediamines and aldehydes catalyzed by a highly recyclable nonnoble cobalt nanocomposite was developed. A broad set of benzimidazoles can be efficiently synthesized in high yields and with good functional-group tolerance under additive- and oxidant-free mild conditions. The catalyst can be easily recycled for successive uses, and the process permits gram-scale syntheses of benzimidazoles.

Diphosphorus tetraiodide (P2I4): An efficient catalyst for synthesis of 2-Aryl-1,3-benzazoles via cyclocondensation of o-Amino/Mercaptan/Hydroxy anilines with aryl acids

An efficient and versatile approach for the synthesis of 2-substituted 1,3-benzazoles has been developed via diphosphorus tetraiodide (P2I4) catalyzed condensation reaction of ortho-substituted anilines (–NH2, –SH and –OH) with various aromatic acids to give benzimidazoles, benzothiazoles and benzoxazoles in excellent yields. Additionally, the synthetic approach reported herein has advantages such as mild reaction conditions, broad substrate scopes as well as simple one-pot operation, common for all the three 1,3-benzazoles, which makes this strategy highly attractive.

Benzimidazole compounds having activity against hepatitis B viruses and antibacterial activity, and a synthetic method and application thereof

Benzimidazole compounds having activity against hepatitis B viruses and antibacterial activity, and a synthetic method and application thereof are disclosed. Structures of the compounds are shown as ageneral formula (I) in the description. The synthetic method of the compounds, and the application of the compounds in preparation of medicines against hepatitis B viruses are also disclosed. The compounds have certain anti-HBV activity and antibacterial activity, and the activity against hepatitis B viruses of the compounds is equivalent to that of tenofovir that is a clinical anti-HBV medicine.Antibacterial activity screening shows that the compounds have good suppressing activity for Staphylococcus aureus. In the fields of compound structures, synthetic methods and bioactivity, the compounds have significant scientific significance and application prospects for developing novel anti(hepatitis B) medicines of a novel structure type and antibacterial medicines.