59050-38-3

Basic information

• Product Name: 2-phenyl-1H-indole-3-carboxylic acid
• Synonyms: 2-phenyl-1H-indole-3-carboxylic acid
• CAS NO: 59050-38-3
• Molecular Formula: C₁₅H₁₁NO₂
• Molecular Weight: 237.25
• Mol File: 59050-38-3.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-phenyl-1H-indole-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-phenyl-1H-indole-3-carboxylic acid(59050-38-3)
• EPA Substance Registry System: 2-phenyl-1H-indole-3-carboxylic acid(59050-38-3)

Safety Data

• Hazardous Substances Data: 59050-38-3(Hazardous Substances Data)

Usage

General Description

2-phenyl-1H-indole-3-carboxylic acid is a chemical compound with the molecular formula C16H11NO2. It is a derivative of indole, a heterocyclic aromatic organic compound. This particular compound contains a phenyl group and a carboxylic acid group attached to the indole core, making it a carboxylic acid derivative of indole. It is commonly used in the synthesis of pharmaceuticals, agrochemicals, and organic compounds, and its properties make it suitable for a variety of applications in the chemical industry.

Upstream product

• 948-65-2 2-phenyl-indole 
• 124-38-9 carbon dioxide 
• 64-18-6 formic acid 
• 17375-64-3 3-acetyl-2-phenylindole 
• 3342-78-7 2-(2-aminophenyl)acetic acid 
• 3740-52-1 2-(2-nitrophenyl)acetic acid 
• 98-88-4 benzoyl chloride 
• 98911-34-3 2-(2-Aminophenyl)essigsaeure-tert-butylester 
• 101727-26-8 (2-phenyl-indol-3-yl)-glyoxal 

Downstream Products

• 1278540-60-5 C₃₀H₂₂ClNO₃ 
• 1278540-65-0 C₂₃H₁₉NO₂ 
• 1278540-55-8 C₂₃H₁₆ClNO₃ 
• 27005-52-3 2-(2-phenyl-1H-indol-3-yl)acetonitrile 
• 4662-03-7 2-phenylindole-3-acetic acid 
• 36779-17-6 methyl 2-phenyl-1H-indole-3-carboxylate 
• 948-65-2 2-phenyl-indole 

Relevant articles and documents

Lithium tert-butoxide-mediated carboxylation reactions of unprotected indoles and pyrroles with carbon dioxide

Unprotected indoles and pyrroles were found to undergo base-mediated carboxylation reactions under ambient pressure of carbon dioxide. It was found that this transition metal-free carboxylation reaction proceeded smoothly with the use of a large excess of LiOtBu.

Design and synthesis of indomethacin analogues that inhibit P-glycoprotein and/or multidrug resistant protein without Cox inhibitory activity

We designed and synthesized conformationally restricted analogues and regioisomers of the nonsteroidal anti-inflammatory drug indomethacin. Evaluation of the inhibitory effects of these compounds on COX, P-glycoprotein, and multidrug resistance indicated that NSAIDS modulation of multidrug-resistant P-glycoprotein and multidrug-resistant protein-1 is not associated with COX-1 and COX-2 inhibitory activities.

Prototropic Generation of Dipoles. A New Synthesis of Indole-3-carboxylic Acids

Imines of (2-aminophenyl)acetic acid give 2-substituted indole-3-carboxylic acids under mild conditions; the cyclisation is thought to involve a 1,5-dipole and initially to give the corresponding indolines.