59050-38-3

Usage

Uses

Used in Pharmaceutical Synthesis:
2-phenyl-1H-indole-3-carboxylic acid is utilized as a key intermediate in the synthesis of various pharmaceuticals. Its structural features allow for the development of new drugs with potential therapeutic applications, making it a valuable component in medicinal chemistry.
Used in Agrochemical Production:
In the agrochemical industry, 2-phenyl-1H-indole-3-carboxylic acid serves as a precursor for the creation of novel compounds with pesticidal or herbicidal properties. Its incorporation into these products can enhance their effectiveness in agricultural settings.
Used in Organic Compounds Synthesis:
2-phenyl-1H-indole-3-carboxylic acid is employed as a building block in the synthesis of a variety of organic compounds. Its reactivity and functional groups make it suitable for use in organic synthesis, contributing to the development of new materials and chemical entities.
Used in Chemical Industry Applications:
The properties of 2-phenyl-1H-indole-3-carboxylic acid make it suitable for a variety of applications within the chemical industry. Its versatility allows it to be used in the development of new chemical processes, materials, and products that can meet diverse industrial needs.

Upstream product

• 101727-26-8 (2-phenyl-indol-3-yl)-glyoxal 
• 98-88-4 benzoyl chloride 
• 98911-34-3 2-(2-Aminophenyl)essigsaeure-tert-butylester 
• 3342-78-7 2-(2-aminophenyl)acetic acid 
• 64-18-6 formic acid 
• 948-65-2 2-phenyl-indole 
• 124-38-9 carbon dioxide 
• 17375-64-3 3-acetyl-2-phenylindole 
• 3740-52-1 2-(2-nitrophenyl)acetic acid 

Downstream Products

• 1278540-60-5 C₃₀H₂₂ClNO₃ 
• 1278540-65-0 C₂₃H₁₉NO₂ 
• 1278540-55-8 C₂₃H₁₆ClNO₃ 
• 27005-52-3 2-(2-phenyl-1H-indol-3-yl)acetonitrile 
• 4662-03-7 2-phenylindole-3-acetic acid 
• 36779-17-6 methyl 2-phenyl-1H-indole-3-carboxylate 
• 948-65-2 2-phenyl-indole 

Relevant academic research and scientific papers

Lithium tert-butoxide-mediated carboxylation reactions of unprotected indoles and pyrroles with carbon dioxide

Unprotected indoles and pyrroles were found to undergo base-mediated carboxylation reactions under ambient pressure of carbon dioxide. It was found that this transition metal-free carboxylation reaction proceeded smoothly with the use of a large excess of LiOtBu.

Design and synthesis of indomethacin analogues that inhibit P-glycoprotein and/or multidrug resistant protein without Cox inhibitory activity

We designed and synthesized conformationally restricted analogues and regioisomers of the nonsteroidal anti-inflammatory drug indomethacin. Evaluation of the inhibitory effects of these compounds on COX, P-glycoprotein, and multidrug resistance indicated that NSAIDS modulation of multidrug-resistant P-glycoprotein and multidrug-resistant protein-1 is not associated with COX-1 and COX-2 inhibitory activities.

Base-mediated carboxylation of unprotected indole derivatives with carbon dioxide

A simple and straightforward method for the preparation of indole-3-carboxylic acids was discovered through the direct carboxylation of indoles with atmospheric pressure of carbon dioxide (CO2) under basic conditions. The key for the reaction was found to be the use of a large excess of LiOtBu as a base to suppress the undesired decarboxylation side reaction.

Efficient solid-phase synthesis of 2,3-substituted indoles

The development of the solid-phase version of the modified Madelung indole synthesis is reported. The chemistry was initiated with the reductive amination of Bal resin using an ortho substituted aniline. The resin bound aniline was acylated with a variety of acid chlorides followed by cyclization with base to provide the desired indole after TFA-promoted cleavage from the resin.

Prototropic Generation of Dipoles. A New Synthesis of Indole-3-carboxylic Acids

Imines of (2-aminophenyl)acetic acid give 2-substituted indole-3-carboxylic acids under mild conditions; the cyclisation is thought to involve a 1,5-dipole and initially to give the corresponding indolines.