5912-58-3

Usage

Uses

Used in Pharmaceutical Synthesis:
α-Chloroethyl acetate is used as a key intermediate in the synthesis of various pharmaceuticals, contributing to the development of new drugs and therapeutic agents.
Used as a Solvent:
In the Chemical Industry, α-Chloroethyl acetate is used as a solvent for cellulose acetate and certain resins, facilitating the manufacturing process and improving the properties of the final products.
Used in Agricultural Chemical Production:
α-Chloroethyl acetate is utilized in the production of pesticides, herbicides, and other agricultural chemicals, enhancing crop protection and contributing to increased agricultural productivity.

InChI:InChI=1/C4H7ClO3/c1-3(6)8-4(2,5)7/h7H,1-2H3

Upstream product

• 141-78-6 ethyl acetate 
• 75-36-5 acetyl chloride 
• 56-23-5 tetrachloromethane 
• 13043-82-8 acetyl propionyl peroxide 
• 91-17-8 decalin 
• 7782-50-5 chlorine 
• 75-07-0 acetaldehyde 

Downstream Products

• 15657-96-2 1-cyanoethyl acetate 
• 542-10-9 ethylidene diacetate 
• 75-07-0 acetaldehyde 
• 75-36-5 acetyl chloride 
• 87589-29-5 4-(tert-Butoxycarbonylamino-methyl)-cyclohexanecarboxylic acid 1-acetoxy-ethyl ester 
• 64-19-7 acetic acid 
• 7647-01-0 hydrogenchloride 
• 123-63-7 paracetaldehyde 
• 127-08-2 potassium acetate 
• 13505-39-0 3-hydroxy-1-phenyl-butan-1-one 
• 581106-34-5 [3-[acetyl(phenylmethoxy)amino]propyl]-phosphonic acid bis[1-(acetyloxy)ethyl] ester 
• 105280-77-1 Acetoxyethyl 5R,3-(4-carbamoylphenoxy)-6S-(1R-hydroxyethyl)-7-oxo-4-thia-1-azabicyclo[3,2,0]hept-2-ene-2-carboxylate 
• 1198298-27-9 [Cr(cyclopentadienyl)((xylyl)NC(Me)CHC(Me)N(xylyl))Cl] 
• 1065614-72-3 [Cr(cyclopentadienyl)((xylyl)NC(Me)CHC(Me)N(xylyl))(CHMeOOCMe)] 

Relevant academic research and scientific papers

C-H functionalization of sp3centers with aluminum: A computational and mechanistic study of the baddeley reaction of decalin

Decalin undergoes reaction with aluminum trichloride and acetyl chloride to form a tricyclic enol ether in good yield, as first reported by Baddeley. This eye-catching transformation, which may be considered to be an aliphatic Friedel-Crafts reaction, has not previously been studied mechanistically. Here we report experimental and computational studies to elucidate the mechanism of this reaction. We give supporting evidence for the proposition that, in the absence of unsaturation, an acylium ion acts as a hydride acceptor, forming a tertiary carbocation. Loss of a proton introduces an alkene, which reacts with a further acylium ion. A concerted 1,2-hydride shift/oxonium formation, followed by elimination, leads to formation of the observed product.

Lifetime of acyloxy radicals produced by decomposition of acetylpropionyl peroxide

The authors consider thermolysis of 0.5 M solutions of acetylpropionyl peroxide in CCl4 and 333 and 343 K as well as photolysis of 0.5 M solutions of acetylpropionyl peroxide in CCl4 and 253-333 K and photolysis of methanol solutions of acetylpropionyl peroxide with added 1 m CCl4 at temperature of 193-253 K.The effects of chemical nuclear polarization and reaction yields were analyzed to determine the decarboxylation rate constants of acyloxy radicals that were produced by thermolysis and photolysis of acetylpropionyl peroxide. - Keywords: acyloxy radical; decarboxylating rate constant; chemical nuclear polarization.

Chlorination of Carboxylic Acid Derivatives. IX. Liquid Phase Chlorination of Aliphatic C2-C8 Alkyl Acetates. EI Mass Spectra of Monochlorinated Esters

A series of aliphatic alkyl acetates from ethyl to octyl acetate was chlorinated in the liquid phase in order to obtain monochlorinated products.The chlorination of esters was carried out with chlorine in the liquid phase in the absence and in the presence of benzene and with sulfuryl chloride in the presence of Bz2O2.The products were determined by gas-liquid chromatography and gas-liquid chromatography-mass spectrometry.Chlorination is appreciably deactivated at the 1-position, particularly with SO2Cl2, the deactivation at the 2-position being strongest with Cl2 in the presence of benzene.The amounts of 1-chloro and ω-chloro isomers constituted the greatest disparity between the chlorination methods.The most characteristic mass spectral fragment ions of the 35 chlorinated alkyl acetates are given.