592479-02-2Relevant academic research and scientific papers
COMPOUNDS USEFUL IN HIV THERAPY
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, (2020/06/19)
The invention relates to compounds of Formula (I), (Ia), (Ib), (II) or (III), salts thereof, pharmaceutical compositions thereof, as well as therapeutic methods of treatment and prevention.
TFA-catalysed tandem double cyclisation: A one-pot, metal-free routes for novel indolo-imidazo[1,2-a]pyridine derivatives
Ganesher, Asha,Panda, Gautam
, (2019/11/11)
A transition-metal free, one-pot tandem synthetic routes for novel indole and imidazo[1,2-a]pyridine derivative hybrids have been established. An efficient three-component reaction was designed with incorporation of two sequential Groebke–Blackburn–Bienay
Application of the Cleavable Isocyanide in Efficient Approach to Pyroglutamic Acid Analogues with Potential Biological Activity
Jassem,Al-Ajely,Almashal,Chen
, p. 2562 - 2570 (2020/02/25)
Two efficient procedures have been developed for the synthesis of pyroglutamic acid analogues 28, 29, and 34. According to the first method the Ugi (4C3C) reaction is followed by a post-transformation reaction, and the second method involves the Michael a
New entry to convertible isocyanides for the Ugi reaction and its application to the stereocontrolled formal total synthesis of the proteasome inhibitor omuralide
Gilley, Cynthia B.,Buller, Matthew J.,Kobayashi, Yoshihisa
, p. 3631 - 3634 (2008/02/12)
The development of a new convertible isocyanide, indole-isocyanide, for ready access to pyroglutamic acids culminated in the formal total synthesis of the proteasome inhibitor omuralide featuring a stereocontrolled Ugi reaction. Indole-isocyanide was name
Synthesis of 3-methoxyquinolines via cyclization of 1-isocyano-2-(2-lithio-2-methoxyethenyl)benzenes
Kobayashi, Kazuhiro,Yoneda, Keiichi,Mizumoto, Tatsuya,Umakoshi, Hironobu,Morikawa, Osamu,Konishi, Hisatoshi
, p. 4733 - 4736 (2007/10/03)
2-(2-Isocyanophenyl)acetaldehyde dimethyl acetals were treated with excess LDA to generate 1-isocyano-2-(2-lithio-2-methoxyethenyl)benzenes, which cyclized intramolecularly to afford 3-methoxyquinolines in good to excellent yields.
