951024-67-2Relevant academic research and scientific papers
Synthesis of functionalized pyroglutamic acids, part 1: The synthetic utility of N-acylindole and the ugi reaction with a chiral levulinic acid
Buller, Matthew J.,Gilley, Cynthia B.,Nguyen, Brian,Olshansky, Lisa,Fraga, Breena,Kobayashi, Yoshihisa
scheme or table, p. 2244 - 2248 (2009/04/10)
A variety of pyroglutamic acid derivatives are readily synthesized via N-acylindole intermediates obtained by the Ugi reaction. For the preparation of functionalized pyroglutamic acid derivatives, the diastereoselectivity of the Ugi 4-center 3-component c
New entry to convertible isocyanides for the Ugi reaction and its application to the stereocontrolled formal total synthesis of the proteasome inhibitor omuralide
Gilley, Cynthia B.,Buller, Matthew J.,Kobayashi, Yoshihisa
, p. 3631 - 3634 (2008/02/12)
The development of a new convertible isocyanide, indole-isocyanide, for ready access to pyroglutamic acids culminated in the formal total synthesis of the proteasome inhibitor omuralide featuring a stereocontrolled Ugi reaction. Indole-isocyanide was name
