26415-26-9

Usage

Uses

Used in Organic Synthesis:
(thiophen-3-ylmethyl)propanedioic acid is used as a building block for the synthesis of heterocyclic compounds, leveraging its structural properties to create a diverse array of complex organic molecules.
Used in Medicinal Chemistry:
In the pharmaceutical industry, (thiophen-3-ylmethyl)propanedioic acid is used as a key component in the development of novel drugs. Its unique structure allows for the creation of new pharmaceuticals with a wide range of biological activities.
Used in Agrochemical Development:
(thiophen-3-ylmethyl)propanedioic acid is also utilized in the development of new agrochemicals, where its structural properties can be harnessed to produce compounds with various applications in agriculture.
Used in Material and Polymer Development:
Due to its unique chemical structure, (thiophen-3-ylmethyl)propanedioic acid has potential uses in the development of new materials and polymers, contributing to advancements in various industrial applications.

Upstream product

• 26415-25-8 3-thiophen-3-yl methyl malonic acid diethyl ester 
• 34846-44-1 3-Bromomethylthiophene 
• 67237-53-0 3-ethynylthiophene 
• 124-38-9 carbon dioxide 
• 616-44-4 3-Methylthiophene 

Downstream Products

• 5650-52-2 4,5-dihydro-6H-cyclopenta[b]thiophen-6-one 
• 13191-40-7 3-(2,5-dibromothiophen-3-yl)propionic acid 
• 59311-67-0 2-(3-thienyl)ethylamine 
• 128426-57-3 3-(3'-thienyl)propyl toluene-p-sulphonate 
• 20905-98-0 3-(3-thienyl)-propyl alcohol 

Relevant academic research and scientific papers

Copper-catalyzed carboxylation of hydroborated disubstituted alkenes and terminal alkynes with cesium fluoride

A protocol for the hydrocarboxylation of disubstituted alkenes and terminal alkynes providing access to different secondary carboxylic acids and malonic acid derivatives has been developed. This methodology relies on an initial hydroboration using 9-BBN followed by carboxylation with carbon dioxide in the presence of a copper catalyst and the additive, cesium fluoride. Different cyclohexene, styrene, and stilbene derivatives could be utilized, and alkynes could be transformed into their corresponding dicarboxylic acids in good yields. Finally, six different terpenoids were carboxylated using the developed procedure. (Chemical Equation Presented).

Novel synthesis of thianinhydrin

The synthesis of the previously reported thianinhydrin (12) was achieved from 3-methylthiophene via the corresponding 5,6-dihydrocyclopenta[b]thiophen-4,6-dione (10). Conversion of 10 to the tricarbonyl (12) proceeded in good yield using dimethydioxirane oxidation of 5,6-dihydro-5-dimethyl aminomethylenecyclopenta[b]thiophen-4,6-dione (14). The fluorescence intensity of the zinc salt of the product of 12 and glycine was similar to that obtained from the product of ninhydrin and the same amino acid.

SYNTHESE ET PROPRIETES DES DEUX FORMES ENANTIOMERES DE POLY(THIOPHENES) CHIRAUX

Chiral poly(thiophenes) obtained from two enantiomerically pure monomers can stereoselectively recognize anions used as doping agents during voltammetric cycles.

Enantioselective Chiral Poly(thiophenes)

Chiral poly(thiophenes) have been synthesized by electropolymerisation: they exhibit high specific rotation, stability, and conductivity and can stereoselectively recognize chiral anions used as doping agents during voltammetric cycles.