59507-42-5

Basic information

• Product Name: 1-(4-CHLOROBENZYL)PIPERIDINE
• Synonyms: 1-(4-CHLOROBENZYL)PIPERIDINE
• CAS NO: 59507-42-5
• Molecular Formula: C₁₂H₁₆ClN
• Molecular Weight: 209.72
• Mol File: 59507-42-5.mol
• Article Data: 18

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(4-CHLOROBENZYL)PIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-CHLOROBENZYL)PIPERIDINE(59507-42-5)
• EPA Substance Registry System: 1-(4-CHLOROBENZYL)PIPERIDINE(59507-42-5)

Safety Data

• Hazardous Substances Data: 59507-42-5(Hazardous Substances Data)

Usage

General Description

1-(4-chlorobenzyl)piperidine is a chemical compound with the molecular formula C13H17ClN. It is a piperidine derivative with a chlorobenzyl group attached to the nitrogen atom. 1-(4-CHLOROBENZYL)PIPERIDINE is commonly used as an intermediate in the synthesis of various pharmaceutical drugs and organic compounds. It possesses important medicinal properties and has been studied for its potential use in the treatment of various diseases and conditions. Additionally, it is also used in research and development of new drugs and in organic chemical synthesis as a building block for more complex molecules. Overall, 1-(4-chlorobenzyl)piperidine is a versatile and important chemical compound with a wide range of applications in the pharmaceutical and chemical industries.

Upstream product

• 110-89-4 piperidine 
• 873-76-7 para-Chlorobenzyl alcohol 
• 2591-86-8 N-Formylpiperidine 
• 622-95-7 4-chlorobenzyl bromide 
• 104-88-1 4-chlorobenzaldehyde 
• 660-88-8 5-aminopentanoic acid 
• 18811-61-5 N-(methoxymethyl)piperidine 
• 1679-18-1 4-Chlorophenylboronic acid 
• 623-03-0 4-Cyanochlorobenzene 
• 26163-40-6 N-(4-chlorobenzoyl)piperidine 
• 122-01-0 4-chloro-benzoyl chloride 
• 104-83-6 1-Chloro-4-(chloromethyl)benzene 
• 67-56-1 methanol 
• 55591-37-2 1,1'-((4-chlorophenyl)methylene)dipiperidine 

Relevant articles and documents

Iodine-Mediated Coupling of Cyclic Amines with Sulfonyl Hydrazides: an Efficient Synthesis of Vinyl Sulfone Derivatives

An efficient iodine-mediated coupling of cyclic amines with sulfonyl hydrazides is reported. This transformation opens a new route to the synthesis of vinyl sulfones derivatives, which is a common structural motif in natural products and pharmaceuticals. Tentative mechanistic studies suggest that this reaction is likely to involve a radical process.

Hydrosilylative Reduction of Tertiary Amides to Amines Catalyzed by N-(Phosphinoaryl)anilido Complexes of Iron and Cobalt

The synthesis and structural characterization of low-coordinate Fe(II) and Co(II) complexes supported by the monoanionic P,N-ligand N-(2-dicyclohexylphosphinophenyl)-2,6-diisopropylanilide are described. A three-coordinate (P,N)Fe-hexamethyldisilazide complex (2), and four-coordinate (P,N)Fe- (3-Fe) and (P,N)Co-alkyl (3-Co) complexes were evaluated as pre-catalysts for the hydrosilylative reduction of amides with PhSiH3 (5 mol % pre-catalyst, 1 equiv. PhSiH3, 80 °C, 1–24 h). The Fe complex 2 proved to be more broadly effective for the reduction of a variety of tertiary amide substrates, and was shown to mediate the reduction of N,N-dibenzylbenzamide at a loading of 1 mol %, to achieve near quantitative formation of tribenzylamine in 1 h (80 °C). Complex 2 also proved effective for the hydrosilylation of tertiary amides under ambient conditions (5 mol % Fe, 24 h), which is a unique example of room temperature amide hydrosilylation mediated by an Fe catalyst without the need for photochemical activation. Given the widespread use of amide reduction protocols in synthesis, the development of efficient Fe-based catalysts that operate under mild conditions is an important target.

A Manganese Pre-Catalyst: Mild Reduction of Amides, Ketones, Aldehydes, and Esters

A new (N-phosphinoamidinate)manganese complex is shown to be a useful pre-catalyst for the hydrosilative reduction of carbonyl compounds, and in most cases at room temperature. The Mn-catalyzed reduction of tertiary amides to tertiary amines, with a useful scope, is demonstrated for the first time by use of this catalyst, and is competitive with the most effective transition-metal catalysts known for such transformations. Ketones, aldehydes, and esters were also successfully reduced under mild conditions by using this new Mn catalyst.