597-32-0Relevant academic research and scientific papers
Cationic alkyl glycoside quaternary ammonium salt surfactant and preparation process thereof
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Paragraph 0030-0032; 0038-0040; 0046-0048; 0054-0056; ..., (2021/11/27)
The invention discloses a cationic alkyl glucoside quaternary ammonium salt surfactant and a preparation process thereof. Reaction of 3 - chlorine -2 - methyl propylene with hypochlorous acid is firstly reacted with hypochlorous acid, and then the intermediate 1 is prepared by reaction with N, N - diethylaminopropylmethyldimethoxysilane to prepare the intermediate 2, and the intermediate 2 3 is reacted with the alkylglucoside to form a cationic alkyl glycoside quaternary ammonium salt 3 surfactant which has a quaternary ammonium 4 salt structure and 4 can be efficiently sterilized to play an antibacterial role. In addition, the surfactant has the organic silicon structure, has the characteristics of organic matter and inorganic substance, endows the surfactant with excellent high temperature resistance, and also has the function of organic silicon cationic surfactant, and plays a role in solubilization and emulsification.
Reactions of 2-substituted epichlorohydrins
Tanyeli,Demir,Akhmedov,Ozgul,Kandemir
, p. 2967 - 2980 (2007/10/03)
2-Substituted epichlorohydrins have been synthesized by starting with 1,2-dichloro acetone and various alkyl and aryl halides via dichlorohydrins followed by cyclization. The reactive 2-substituted epichlorohydrins were subjected to nucleophilic attacking of azide and cyanide ions to afford corresponding β-azido alcohols and α,β-unsaturated nitriles.
BRANCHED-CHAIN DERIVATIVES OF ACYCLIC ADENOSINE ANALOGS: ALKYL AND HYDROXYMETHYL DERIVATIVES OF S-ADENOSYL-L-HOMOCYSTEINASE INHIBITORS SUBSTITUTED AT THE 2- AND 3-POSITION OF THE SIDE CHAIN
Holy, Antonin
, p. 248 - 265 (2007/10/02)
Reaction of 1,3-dichloro-2-propanone (VII) with methylmagnesium chloride, followed by alkaline hydrolysis, afforded 2-methylpropane-1,2,3-triol (VIII) which on treatment with 2,2-dimethoxypropane and subsequent tosylation give 4-(p-toluenesulfonyloxymethyl)-2,2,4-trimethyl-1,3-dioxolane (IXb).Compound IXb was condensed with sodium salt of adenine and the intermediate X was acid-hydrolysed to give 9-(RS)-(2,3-dihydroxy-2-methylpropyl)adenine (XI).Oxidation of XI with sodium periodate led to 9-(2-oxopropyl)adenine (XII). 9-(RS)-(2-Hydroxy-2-hydroxymethyloctyl)adenine (XVI) was obtained analogously from compound VII and hexylmagnesium bromida via triol XIV.Methyl 2-bromomethyl-2-propenoate (XVII) reacted with sodium salt of adenine and the resulting methyl 2-(adenin-9-ylmethyl)-2-propenoate (XVIII) was hydroxylated with sodium perchlorate and osmium tetroxide.The obtained methyl (RS)-2-(adenin-9-ylmethyl)-2,3-dihydroxypropanoate (XIX) was alkali-hydrolysed to give sodium salt of the acid XX.Reduction of ester XIX with sodium borohydride furnished 9-(RS)-(2,3-dihydroxy-2-hydroxymethylpropyl)adenine (XXI). 1-Nonen-3-ol (XXIII), obtained by reaction of propenal with hexylmagnesium bromide, was converted by hydroxylation with osmium tetroxide into nonane-1,2,3-triol (XXIVa) and further into its 1-O-p-toluenesulfonate XXIVb which reacted with 2,2-dimethoxypropane to give 2,2-dimethyl-4-hexyl-5-(p-toluenesulfonyloxymethyl)-1,3-dioxolane (XXV).Compound XXV reacted with adenine and the resulting intermediate XXVI was converted into 9-(RS)-(2,3-dihydroxynonyl)adenine (XXVII) by acid hydrolysis. 9-(3-Methyl-2-buten-1-yl)adenine (XXVIII), obtained by alkylation of sodium salt of adenine with 1-bromo-3-methyl-2-butene, was oxidized with potassium permanganate in an acid medium to give 9-(3-hydroxy-2-oxo-3-methylbutyl)adenine (XXIX).This compound was converted into 9-(RS)-(2,3-dihydroxy-3-methylbutyl)adenine (XXX) by reduction with sodium borohydride. 4-C-Hydroxymethyl-1,2-O-isopropylidene-α-D-xylofuranose (XXXII) reacted with 2,2-dimethoxypropane under formation of 4-C-hydroxymethyl-1,2:3,5-di-O-isopropylidene derivative XXXIIIa whose p-toluenesulfonyl derivative XXXIIIb on treatment with adenine afforded 4-C-(adenin-9-yl)methyl-1,2:3,5-di-O-isopropylidene-α-D-xylofuranose (XXXIV).Acid hydrolysis of this compound, followed by oxidation in an alkaline medium, gave (2S,3R)-4-(adenin-9-yl)-3-hydroxymethyl-2,3-dihydroxybutanoic acid, isolated as its ethyl ester XXXVI.
Synthesis and pharmacological study of aryloxypropanolamines substituted on carbon 2
Galons,Combet Farnoux,Miocque,et al.
, p. 23 - 27 (2007/10/02)
In a series of aryloxypropanolamines, substitution on carbon 2 by alkyl, aryl or aralkyl groups lowers the β-blocking activity. This effect increases with the size of the substituent.
